Beatriz Fontoura, Ph.D. Professor Endowed Title Ruth S. Harrell Professorship in Medical Research School Medical School Department Cell Biology Graduate Programs Cancer Biology, Molecular Microbiology Biography EXPERIENCE UT Southwestern, Department of Cell Biology, Professor (2012-present). UT Southwestern, Department of Cell Biology, Associate Professor (2007-2012). UT Southwestern, Department of Cell Biology, Assistant Professor (2005-2007). University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology, Assistant Professor (2001-2005). Howard Hughes Medical Institute, Laboratory of Cell Biology, The Rockefeller University, New York, N.Y., Post-Doctoral Associate (1996-2001). New York University School of Medicine, New York, N.Y., Department of Pathology, Graduate Student (PhD) (1991 - 1996). Cornell University Medical College, New York, N.Y., Department of Physiology, Visiting Fellow (1988-1990). Paulista School of Medicine, Sao Paulo, S.P., Brazil, Department of Biochemistry, Graduate Student (MS), (1985-1988). University of Sao Paulo, Brazil, Biochemistry Laboratory, University Hospital, Staff Member (1984-1985). Education Graduate School New York University Publications Featured Publications Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis. Mei M, Cupic A, Miorin L, Ye C, Cagatay T, Zhang K, Patel K, Wilson N, McDonald WH, Crossland NA, Lo M, Rutkowska M, Aslam S, Mena I, Martinez-Sobrido L, Ren Y, García-Sastre A, Fontoura BMA, Proc Natl Acad Sci U S A 2024 May 121 22 e2314166121 Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex. Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Haddad C, Gao S, Esparza M, Cagatay T, Batten K, El Zahed SS, Arnaoutov A, Zhong H, Shay JW, Tolbert BS, Dasso M, Lynch KW, García-Sastre A, Fontoura BMA, Nat Commun 2023 Apr 14 1 2304 Viral-host interactions during splicing and nuclear export of influenza virus mRNAs. Esparza M, Bhat P, Fontoura BM, Curr Opin Virol 2022 Jul 55 101254 Nuclear speckle integrity and function require TAO2 kinase. Gao S, Esparza M, Dehghan I, Aksenova V, Zhang K, Batten K, Ferretti MB, Begg BE, Cagatay T, Shay JW, García-Sastre A, Goldsmith EJ, Chen ZJ, Dasso M, Lynch KW, Cobb MH, Fontoura BMA, Proc Natl Acad Sci U S A 2022 Jun 119 25 e2206046119 Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein. White K, Esparza M, Liang J, Bhat P, Naidoo J, McGovern BL, Williams MAP, Alabi BR, Shay J, Niederstrasser H, Posner B, García-Sastre A, Ready J, Fontoura BMA, J Med Chem 2021 Jul Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression. Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA, Sci Adv 2021 Feb 7 6 Viral-induced alternative splicing of host genes promotes influenza replication. Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW, Elife 2020 12 9 SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A, Proc Natl Acad Sci U S A 2020 11 117 45 28344-28354 Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway. Aksenova V, Smith A, Lee H, Bhat P, Esnault C, Chen S, Iben J, Kaufhold R, Yau KC, Echeverria C, Fontoura B, Arnaoutov A, Dasso M, Nat Commun 2020 09 11 1 4577 Chemical intervention of influenza virus mRNA nuclear export. Esparza M, Mor A, Niederstrasser H, White K, White A, Zhang K, Gao S, Wang J, Liang J, Sho S, Sakthivel R, Sathe AA, Xing C, Muñoz-Moreno R, Shay JW, García-Sastre A, Ready J, Posner B, Fontoura BMA, PLoS Pathog. 2020 Apr 16 4 e1008407 Results 1-10 of 52 1 2 3 4 5 Next Last Honors & Awards UM Sylvester Comprehensive Cancer Center Award (2004) Stanley J. Glaser Award (2002) UM Sylvester Comprehensive Cancer Center Award (2002)
