Jyothsna Gattineni, M.D.

Jyothsna Gattineni, M.D., earned her medical degree from Stanley Medical College and Hospital in Chennai, India. She subsequently completed residencies in pediatrics in the United Kingdom and at Driscoll Children’s Hospital in Corpus Christi, Texas. Dr. Gattineni then completed a pediatric nephrology fellowship at UT Southwestern/Children’s Medical Center. Dr. Gattineni practices at UT Southwestern and Children’s Health and serves as Chief of Pediatric Nephrology at both institutions. 

One of the largest pediatric nephrology programs nationwide, UT Southwestern’s Division of Pediatric Nephrology is the main provider of clinical and testing services for children with kidney disease, bone disease, and hypertension at Children’s Medical Center Dallas and Children’s Medical Center Plano.

As an NIH-funded physician-scientist, Dr. Gattineni aims to better understand kidney disease and open the door to new treatments. Her research focuses on understanding the fibroblast growth factor 23 (FGF23) hormone and how it impacts patients with chronic kidney disease. Her lab has characterized the receptors for this hormone, and in doing so, generated a mouse model with a 25- to 50-fold increase in FGF23 levels. Dr. Gattineni is using this model to determine if elevated FGF23 contributes to the bone, vascular, and cardiac disease seen in patients with chronic kidney disease.

Medical School

Stanley Medical College and Hospital (1994)

Residency

Govt. Stanley Medical College Hospital (1995), Internal Medicine & Pediatrics

Residency

The Royal Bolton Hospital (2003), Pediatrics

Residency

Driscoll Children's Hospital - GME (2005), Pediatrics

Fellowship

UT Southwestern/Children's Medical Center (2008), Pediatric Nephrology

Fellowship

UT Southwestern Medical Center (2009), Nephrology

• Chronic kidney disease
• FGF23 and its receptors
• Hemolytic uremic syndrome
• Phosphate homeostasis and disorders of phosphate metabolism
• Tubular Transport

Featured Publications

Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.

Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2

Familial hyperkalemic hypertension: hyperkalemia not hypertension defines dominant KLHL3 disease and may permit earlier recognition and tailored therapy.

Sambharia M, Gattineni J, Noureddine L, Mansilla MA, Thomas CP, J Nephrol 2022 Jan

Sex differences in prenatal programming of hypertension by dexamethasone.

Alhamoud I, Legan SK, Gattineni J, Baum M, Exp Biol Med (Maywood) 2021 Apr 15353702211003294

Clinicopathological features of C3 glomerulopathy in children: a single-center experience.

Drake KA, Ellington N, Gattineni J, Torrealba JR, Hendricks AR, Pediatr. Nephrol. 2019 Oct

Donation after cardiac death kidneys are suitable for pediatric recipients.

MacConmara M, El Mokdad A, Gattineni J, Hwang CS, Pediatr Transplant 2019 Jul e13540

Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone.

Jain J, Legan SK, Alhamoud I, Gattineni J, Baum M, Physiol Rep 2019 Jul 7 12 e14154

Utilizing increased risk for disease transmission (IRD) kidneys for pediatric renal transplant recipients.

Hwang CS, Gattineni J, MacConmara M, Pediatr. Nephrol. 2019 Jun

Phenotypic Severity Scoring System and Categorization for Prune Belly Syndrome: Application to a Pilot Cohort of 50 Living Patients.

Wong DG, Arevalo MK, Passoni NM, Iqbal NS, Jascur T, Kern AJ, Sanchez EJ, Satyanarayan A, Gattineni J, Baker LA BJU Int. 2018 Aug

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case.

Torrealba J, Gattineni J, Hendricks AR Case Rep Nephrol Dial 2018 Jan-Apr 8 1 70-75

Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats.

Mansuri A, Legan SK, Jain J, Alhamoud I, Gattineni J, Baum M Physiol Rep 2017 Nov 5 20

 Featured Books

Inherited Disorders of Calcium, Phosphate, and Magnesium. In Nephrology and Fluid/Electrolyte Physiology Neonatology Questions and Controversies, 3rd ed, Oh W, Baum M, eds.

Gattineni J, Wolf MTF (2018). Philadelphia, PA, Elsevier; 345-389

Postnatal Renal Development.. In Alpern RJ, Caplan MJ, Moe OW, eds. Seldin and Giebisch's The Kidney: Physiology and Pathophysiology. 5th ed.

Baum M, Gattineni J, Satlin LM. (2013). Elsevier; 911-932.

Regulation of Hormone-Sensitive Renal Phosphate Transport. In Litwack G, ed. Hormones and Transport Systems: Vitamins and Hormones. Vol 98.

Gattineni J, Friedman PA. (2015). Elsevier; 249-306.

• Best Pediatric Faculty Teaching Award
  UT Southwestern Medical Center and Children's Health, Dallas (2020)
• Top 5 Capstone Projects
  LEAD Program, UT Southwestern Medical Center, Dallas (2019)
• Editorial Board
  Pediatric Nephrology (2018)
• Best Pediatric Specialists/Doctors in Dallas
  D Magazine (2017-2022)
• Society of Pediatric Research
  Member (2011)
• Best Resident Research Presentation
  Driscoll's Children's Hospital, Texas A&M University, Corpus Christi, Texas (2005)
• Best Resident Case Presentation
  Driscoll's Children's Hospital, Texas A&M University, Corpus Christi, Texas (2004)
• DFW Mom Approved Pediatricians
  

• American Academy of Pediatrics (2017)
• American Society of Nephrology (2005)
• American Society of Pediatric Nephrology (2009)
• International Pediatric Nephrology Association (2009)
• International Society of Nephrology (2009)
• Society of Pediatric Research (2011)