Chai-Wan obtained his bachelor’s and doctoral degrees from Seoul National University in 1997 and 2003 respectively. He studied the role of Prostate transglutaminase (TGase 4) on protecting of Candida albicans infection during PhD course.  He conducted training for Post-doctoral fellowship and working as a Research Scientist from 2005 to 2012 at Jay Horton’s lab in the Department of Molecular Genetics in UT Southwestern medical. He focused his studies on finding molecular mediators in hepatic fatty acids and cholesterol regulation. He was appointed Assistant Professor in the Center for Human Nutrition with a secondary in Molecular Genetics and since then, he has studied enzymes in the fatty acid synthesis pathway in various organs using a tissue specific knockout mouse model.


Seoul National University (1997), Agriculture
Graduate School
Seoul National University (2000), Medicine
Graduate School
Seoul National University (2003), Medical Sciences

Research Interest

  • Lipid metabolism
  • Obesity/diabetes
  • Protein-protein interaction


Featured Publications LegendFeatured Publications

Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG Oncogene 2010 Jan 29 3 356-67
Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress.
Jeong EM, Kim CW, Cho SY, Jang GY, Shin DM, Jeon JH, Kim IG FEBS Lett. 2009 Feb 583 4 648-54
TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation.
Shin DM, Jeon JH, Kim CW, Cho SY, Lee HJ, Jang GY, Jeong EM, Lee DS, Kang JH, Melino G, Park SC, Kim IG FASEB J. 2008 Jul 22 7 2498-507
Colorimetric transglutaminase assays combined with immunological signal amplification.
Jeon JH, Kim CW, Shin DM, Cho SY, Jang GY, Lee HJ, Kim IG Anal. Biochem. 2006 Jan 348 2 327-9