Jinming Gao, Ph.D.
Professor

Download Curriculum Vitae

Jinming Gao received BSc in Chemistry from Peking University in 1991. He carried out graduate studies under George M. Whitesides at Harvard and received a PhD in Physical Organic Chemistry in 1996. Following PhD, he completed postdoctoral training in Biomedical Engineering under Robert S. Langer at MIT.

In 1998, Dr. Gao joined the faculty of Biomedical Engineering at Case Western Reserve University. He was promoted to Associate Professor with tenure in 2004. In 2005, Dr. Gao moved his lab to UT Southwestern, where he is currently a Professor of Oncology, Pharmacology and Otolaryngology. Dr. Gao's lab pioneers the understanding and implementation of molecular cooperativity principles to improve the precision of medicine.  The lab-invented pH threshold sensor technology is currently in Phase I clinical trials for image-guided cancer surgery.  Dr. Gao has served as the past chair of the Gene and Drug Delivery study section, and is a member of the advisory council to the Center for Scientific Review at the National Institutes of Health.

Undergraduate

Peking University , Chemistry

Graduate School

Harvard University (1996)

• Molecular cooperativity in nanomedicine design
• Nanosensor-guided tumor resection
• Nanovaccines and cancer immunotherapy
• pH digitization and metabolic reprograming of lysosomes

Featured Publications

Cooperativity Principles in Self-Assembled Nanomedicine

Li Y, Wang Y, Huang G, Gao J. Chem. Rev. 2018 DOI: 10.1021/acs.chemrev.8b10095

A STING-Activating Nanovaccine for Cancer Immunotherapy

Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu Y, Chen ZJ, Gao J. Nature Nanotech. 2017 12 doi:10.1038/nnano.2017.52

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Wang C, Niederstrasser H, Li Y, Olswald N, Lin R, Jaramillo J, Douglas P, MacMillan E, Wang Z, Brekken R, Posner BA, MacMillan JB, Hang G, Gao J, White MA. Nature Comm. 2017 8 2270

Molecular Basis of pH-Triggered Molecular Self-Assembly

Yang L, Zhao T, Huang G, Sumer B, Gao J. Nature Comm. 2016 7 13214

A Transistor-like pH Nanoprobe for Tumour Detection and Image-Guided Surgery

Zhao T, Huang G,Yang S, Ramezani, S, Li Y, Wang Y, Ma X, Xie XJ, Thibodeaux J, Sun X, Sumer BD, Gao J. Nature BME 2016 1 Accepted

A Nanobuffer Reporter Library for Fine-Scale Imaging and Perturbation of Endocytic Organelles

Wang C, Wang Y, Li Y, Bodemann B, Zhao T, Ma X, Huang G, Hu Z, DeBerardinis RJ, White MA, Gao J. Nature Comm. 2015 6 8524

A Nanoparticle-based Strategy for the Imaging of a Broad Range of Tumours by Nonlinear Amplification of Microenvironment Signals

Wang Y, Zhou K, Huang G, Hensley C, Huang X, Ma X, Zhao T, Sumer BD, DeBerardinis RJ, Gao J Nature Mater. 2014 13 204-212

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

Ma X, Wang Y, Zhao T, Li Y, Su L, Wang Z, Huang G, Sumer BD, Gao J. J. Am. Chem. Soc. 2014 136 11085-11092

• Distinguished Scientist Award
  Society of Experimental Biology and Medicine (2011)
• Distinguished Overseas Young Scientist
  National Natural Science Foundation of China (2007)