Dr. Sandeep Burma obtained his Ph.D. in Molecular Biology from the National Institute of Immunology, New Delhi, India in 1995. After postdoctoral training at Yale University, Pennsylvania State University and Los Alamos National Laboratory, he joined the Lawrence Berkeley National Laboratory as a Scientist Biologist in 1999. He joined the UT Southwestern Medical Center in 2005 where he is currently Associate Professor of Radiation Oncology. Dr. Burma is member of the Harold C. Simmons Comprehensive Cancer center and the Cancer Biology and Genetics, Development & Disease graduate programs of UT Southwestern.
Research in the Burma laboratory is focused on the responses of mammalian cells to DNA double-strand breaks (DSBs), collectively called the DNA damage response (DDR). These responses are of paramount importance in the field of cancer biology - on one hand, DSBs cause cancer, while, on the other hand, these breaks are induced by ionizing radiation or chemotherapies commonly used to treat the disease. The Burma lab is involved in studying DDR events triggered by ionizing radiation and their carcinogenic and cancer therapeutic implications.
- Banaras Hindu University (1988), Zoology
- Graduate School
- Banaras Hindu University (1990), Molecular Genetics
- Graduate School
- National Inst of Immunology (1995), Molecular Biology
- DNA double-strand breaks - sensing, signaling and repair
- Glioblastoma radioresistance - genetic basis and therapeutic targeting
- Radiation-induced gliomagenesis - genetic events underlying transformation
- DNA damage-induced Degradation of EXO1 Limits DNA End Resection to Ensure Accurate DNA Repair.
- Tomimatsu N, Mukherjee B, Harris JL, Boffo FL, Hardebeck M, Potts PR, Khanna KK, Burma S J. Biol. Chem. 2017 May
- Augmented HR Repair Mediates Acquired-temozolomide Resistance in Glioblastoma.
- Gil Del Alcazar CR, Todorova PK, Habib AA, Mukherjee B, Burma S Mol. Cancer Res. 2016 Jun
- Immunofluorescence-based methods to monitor DNA end resection.
- Mukherjee B, Tomimatsu N, Burma S Methods Mol. Biol. 2015 1292 67-75
- DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.
- Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil Del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S Oncogene 2014 Mar
- Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
- Gil Del Alcazar CR, Hardebeck MC, Mukherjee B, Tomimatsu N, Gao X, Yan J, Xie XJ, Bachoo R, Li L, Habib AA, Burma S Clin. Cancer Res. 2014 Feb
- Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.
- Tomimatsu N, Mukherjee B, Catherine Hardebeck M, Ilcheva M, Vanessa Camacho C, Louise Harris J, Porteus M, Llorente B, Khanna KK, Burma S Nat Commun 2014 5 3561
- The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.
- Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, Dubois K, Wiegant WW, Thierry A, Burma S, van Attikum H, Llorente B Nature 2012 Sep 489 7417 581-4
- Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.
- Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S DNA Repair (Amst.) 2012 Apr 11 4 441-8
- The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.
- Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, Burma S Neoplasia 2012 Jan 14 1 34-43
- Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks
- C. V. Camacho, B. Mukherjee, B. McEllin, L-H. Ding, B. Hu, A. Habib, X-J. Xie, C. Nirodi, D. Saha, M. Story, A. Balajee, R. M. Bachoo, D. A. Boothman, and S. Burma Carcinogenesis July 2010 31 1889-1896
Honors & Awards
- Cancer Prevention and Research Institute of Texas (CPRIT)
Individual Investigator Award (2010)
- Japan Society for Promotion of Science (JSPS)
Fellowship for Lecture-Tour of Japan (2009)
- Department of Defense Breast Cancer Research Program (DOD BCRP)
Concept Award (2003)
- Gordon Research Conference
Travel Award (2001)
- Eighth International Workshop for Ataxia Telangiectasia (ATW)
Best Abstract Award (1999)
- Sixteenth All India Cell Biology Conference
Prof. SRV Rao Oration Award (1993)
- Council for Scientific and Industrial Research of India (CSIR)
Ph.D. Fellowship (1990-1995)
- American Association for Cancer Research (AACR)
- American Association for the Advancement of Science (AAAS)
- Radiation Research Society (RRS)
- Society for Neuro-Oncology (SNO)