Biography

Dr. Le received his Ph.D. degree in Microbiology, Immunology and Molecular Genetics (with Owen N. Witte), and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA).  He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral fellowship in Cancer Biology (with Luis F. Parada) from University of Texas Southwestern Medical Center.  He is board certified by the American Board of Dermatology.  Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic.

As a principal investigator in cancer biology, his laboratory investigates how genetic and tumor microenvironmental events interplay to regulate carcinogenesis.  His research group focuses on: (1) identifying the cells of origin of tumorigenesis (how do certain type of cancers originate and develop from adult stem/progenitor cells?); and (2) elucidating the roles of tumor microenvironment in cancer development (how do neighboring non-cancerous cells dictate cancer development and progression?). His laboratory dissects these cellular and molecular mechanisms of tumorigenesis from the developmental perspective. They utilize Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model to address these two fundamental questions in cancer biology as well as elucidating cutaneous nervous system development and regeneration.  His major research goals are to understand mechanisms that initiate Neurofibroma genesis and drive their malignant transformation as well as to develop novel therapeutic targets for Neurofibroma.  Research in Dr. Le's laboratory is supported by R01 and SPORE grants from the National Cancer Institute of the National Institutes of Health as well as grants from the U.S. Department of Defense, the Burroughs Wellcome Fund and other private foundations.

Le Laboratory Website

Dr. Le's ORCID iD and Weblink

Education

Other Post Graduate Training
University of California - Los Angeles (2002)
Graduate School
University of California - Los Angeles (2002), Microbiology, Immunology & Molecular Genetics
Medical School
UCLA David Geffen School of Medicine, UCLA Medical Center (2003)
Internship
Saint Mary's Medical Center-Long Beach (2004), Internal Medicine
Residency
UT Southwestern Medical School (2007), Dermatology
Fellowship
UT Southwestern Graduate School of Biomedical Sciences (2009), Cancer Biology

Research Interest

  • Cancer Biology
  • Neurofibromatosis
  • Stem Cell Biology

Publications

Featured Publications LegendFeatured Publications

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions
Mazal, A.T., Ashikyan, O., Cheng, J., Le, L.Q., Chhabra, A. European Radiology. 2019 29(8):4123-4132.
Creating a Comprehensive Research Strategy for Cutaneous Neurofibromas
Blakeley J.O., Wolkenstein P., Widemann, B.C., Lee, J., Le L.Q., Jackson, R., Stathis, M., Verma S. Neurology 2018 91(2): S1-S4.
Updated Nomenclature for the Human and Mouse Neurofibromatosis type 1 Genes
Anastasaki, C., Le, L.Q., Kesterson, R., Gutmann, D. Neurology:Genetics 2017 3(4): e169
Tumor segmentation of whole-body magnetic resonance imaging in neurofibromatosis type 1 patients: tumor burden correlates
Heffler. M.A., Le, L.Q., Xi, Y., Chhabra, A. Skeletal Radiology 2017 46(1): 93-99
Clinical value of multiparametric whole-body MR imaging over whole-spine magnetic resonance imaging in patients with Neurofibromatosis type 1
Zhang, L., Dessouky, R., Xi, Y., Chhabra, A., Le, L.Q. World Neurosurgery 2017 108:729-737
Defining the Research Landscape for Dermal Neurofibromas
Le, L.Q., Kesterson, R.A., Gutmann, D.H. Oncology Times 2016 38(18): 14-15
The roles of nerve microenvironment for neurofibroma development
Liao, C.P., Pradhan, S., Chen, Z., Patel, A., Liu, C., Booker, R. and Le, L.Q. Oncotarget 2016 7(38): 61500 - 08 61500 - 08
Cutaneous Involvement of Pre-existing Rosai-Dorfman Disease via Post-herpetic Isotopic Response
Malviya, N., Marzuka, A., Maamed-Tayeb, M., Le, L.Q., Vandergriff, T. Journal of Cutaneous Pathology 2016 43(12): 1211-1214
An exophytic, bleeding nodule on left malar region
Hoang, M. T., Mock, J. R., Hoang, M. P., Cohen, J. B. and Le, L. Q. Clin Exp Dermatol 2013 38(2): 217-8
Recurrent perianal red plaque with superficial erosions and pustular exudate in a 16 month old
Hoang, M.T., Carroll, B. T. and Le, L.Q. Clin Exp Dermatol 2013 38(2): 203-4

Honors & Awards

  • Elected to membership in the American Society for Clinical Investigation (ASCI)
    (2015)
  • Thomas L. Shields, M.D. Endowed Professorship in Dermatology
    (2015)
  • Elisabeth Reed Wagner Fund for Research and Clinical Care in Neurofibromatosis and Cardiothoracic Surgery
    (2014)
  • U.S. Department of Defense-Investigator Initiated Research Program Awards
    (2014)
  • European Society for Dermatological Research/Society for Investigative Dermatology Collegiality Travel Awards
    (2012)
  • U.S. Department of Defense-Neurofibromatosis Research Program New Investigator Awards
    (2012)
  • Victor Newcomer Award from the Pacific Dermatologic Association
    (2012)
  • Outstanding Teaching Award from Dermatology residents
    (2010)
  • Disease-Oriented Clinical Scholars (DOCS) Award
    (2009)
  • Career Awards for Medical Scientists from the Burroughs Wellcome Fund
    (2008)
  • President's Research Council Distinguished Young Researcher Award (UTSW)
    (2008)
  • The American Academy of Dermatology Young Investigator Award
    (2008)
  • The Dermatology Foundation Physician Scientist Career Development Award
    (2008)

Professional Associations/Affiliations

  • American Society for Clinical Investigation (ASCI) (2015)
  • American Association for Cancer Research (AACR) (2013)
  • Leaders Society - Dermatology Foundation (2013)
  • Texas Dermatological Society
  • The American Academy of Dermatology
  • The Society for Investigative Dermatology
  • UCLA Association of Chemists and Biochemists