Biography

Dr. Le received his Ph.D. degree in Microbiology, Immunology and Molecular Genetics (with Owen N. Witte), and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA).  He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral fellowship in Cancer Biology (with Luis F. Parada) from University of Texas Southwestern Medical Center.  He is board certified by the American Board of Dermatology.  Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic.

As a principal investigator in cancer biology, his laboratory investigates how genetic and tumor microenvironmental events interplay to regulate carcinogenesis.  His research group focuses on: (1) identifying the cells of origin of tumorigenesis (how do certain type of cancers originate and develop from adult stem/progenitor cells?); and (2) elucidating the roles of tumor microenvironment in cancer development (how do neighboring non-cancerous cells dictate cancer development and progression?). His laboratory dissects these cellular and molecular mechanisms of tumorigenesis from the developmental perspective. They utilize Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model to address these two fundamental questions in cancer biology as well as elucidating cutaneous nervous system development and regeneration.  His major research goals are to understand mechanisms that initiate Neurofibroma genesis and drive their malignant transformation as well as to develop novel therapeutic targets for Neurofibroma.  Research in Dr. Le's laboratory is supported by R01 and SPORE grants from the National Cancer Institute of the National Institutes of Health as well as grants from the U.S. Department of Defense, the Burroughs Wellcome Fund and other private foundations.

Le Laboratory Website

Dr. Le's ORCID iD and Weblink

Education

Other Post Graduate Training
University of California - Los Angeles (2002)
Graduate School
University of California - Los Angeles (2002), Microbiology, Immunology & Molecular Genetics
Medical School
UCLA David Geffen School of Medicine, UCLA Medical Center (2003)
Internship
Saint Mary's Medical Center-Long Beach (2004), Internal Medicine
Residency
UT Southwestern Medical School (2007), Dermatology
Fellowship
UT Southwestern Graduate School of Biomedical Sciences (2009), Cancer Biology

Research Interest

  • Cancer Biology
  • Neurofibromatosis
  • Stem Cell Biology

Publications

Featured Publications LegendFeatured Publications

Tumorigenesis in neurofibromatosis type 1: role of the microenvironment.
Jiang C, McKay RM, Le LQ, Oncogene 2021 Aug
Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing.
Brosseau JP, Sathe AA, Wang Y, Nguyen T, Glass DA, Xing C, Le LQ, Acta Neuropathol Commun 2021 Jan 9 1 11
Insights into the Pathogenesis of NF1-Associated Neoplasms
Bui, A., Jiang, C., McKay, R.M., Klesse, L.J., and Le, L.Q. JID Innovations 2021 3 1 100044
Ashy dermatosis-like hyperpigmentation in a patient taking hydroxyurea.
Li S, Arvisais-Anhalt S, Vandergriff T, Le LQ, JAAD Case Rep 2020 Sep 6 9 797-800
Translating current basic research into future therapies for neurofibromatosis type 1.
Brosseau JP, Liao CP, Le LQ, Br. J. Cancer 2020 May
Heterozygous Tumor Suppressor Microenvironment in Cancer Development
Brosseau, J.P. and Le, L.Q. Trends in Cancer. 2019 5(9):541-546
Krox20 in Epithelial and Glial Stem Cells and Their Niches
Liao, C.P., Tchegnon, E., Le, L.Q. Advances in Stem Cells and Their Niches 2019 3: 139-155
Management of Cutaneous Neurofibroma: Current Therapy and Future Directions
Chamseddin, B.H. and Le, L.Q. Neuro-Oncology Advances 2019 In Press
New Insights Into the Neurofibroma Tumor Cells of Origin
Li, S., Chen, Z., Le, L.Q. Neuro-Oncology Advances 2019 In Press
Double-Stranded RNA Sensing Determines Epithelial Cell Identity
Liao, C.P., Tchegnon, E., Le, L.Q. Journal of Investigative Dermatology. 2019 139(1): 17-19.

Honors & Awards

  • Elected to membership in the American Society for Clinical Investigation (ASCI)
    (2015)
  • Thomas L. Shields, M.D. Endowed Professorship in Dermatology
    (2015)
  • Elisabeth Reed Wagner Fund for Research and Clinical Care in Neurofibromatosis and Cardiothoracic Surgery
    (2014)
  • U.S. Department of Defense-Investigator Initiated Research Program Awards
    (2014)
  • European Society for Dermatological Research/Society for Investigative Dermatology Collegiality Travel Awards
    (2012)
  • U.S. Department of Defense-Neurofibromatosis Research Program New Investigator Awards
    (2012)
  • Victor Newcomer Award from the Pacific Dermatologic Association
    (2012)
  • Outstanding Teaching Award from Dermatology residents
    (2010)
  • Disease-Oriented Clinical Scholars (DOCS) Award
    (2009)
  • Career Awards for Medical Scientists from the Burroughs Wellcome Fund
    (2008)
  • President's Research Council Distinguished Young Researcher Award (UTSW)
    (2008)
  • The American Academy of Dermatology Young Investigator Award
    (2008)
  • The Dermatology Foundation Physician Scientist Career Development Award
    (2008)

Professional Associations/Affiliations

  • American Society for Clinical Investigation (ASCI) (2015)
  • American Association for Cancer Research (AACR) (2013)
  • Leaders Society - Dermatology Foundation (2013)
  • Texas Dermatological Society
  • The American Academy of Dermatology
  • The Society for Investigative Dermatology
  • UCLA Association of Chemists and Biochemists