Dr. Le received his Ph.D. degree in Microbiology, Immunology and Molecular Genetics (with Owen N. Witte), and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA). He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral fellowship in Cancer Biology (with Luis F. Parada) from University of Texas Southwestern Medical Center. He is board certified by the American Board of Dermatology. Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic.
As a principal investigator in cancer biology, his laboratory investigates how genetic and tumor microenvironmental events interplay to regulate carcinogenesis. His research group focuses on: (1) identifying the cells of origin of tumorigenesis (how do certain type of cancers originate and develop from adult stem/progenitor cells?); and (2) elucidating the roles of tumor microenvironment in cancer development (how do neighboring non-cancerous cells dictate cancer development and progression?). His laboratory dissects these cellular and molecular mechanisms of tumorigenesis from the developmental perspective. They utilize Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model to address these two fundamental questions in cancer biology as well as elucidating cutaneous nervous system development and regeneration. His major research goals are to understand mechanisms that initiate Neurofibroma genesis and drive their malignant transformation as well as to develop novel therapeutic targets for Neurofibroma. Research in Dr. Le's laboratory is supported by grants from the National Cancer Institute of the National Institutes of Health as well as grants from the U.S. Department of Defense and the Burroughs Wellcome Fund.
- Graduate School
- University of California - Los Angeles (2002), Microbiology, Immunology & Molecular Genetics
- Medical School
- UCLA David Geffen School of Medicine, UCLA Medical Center (2003)
- Saint Mary's Medical Center-Long Beach (2004), Internal Medicine
- UT Southwestern Medical School (2007), Dermatology
- UT Southwestern Graduate School of Biomedical Sciences (2009), Cancer Biology
- Cancer Biology
- Stem Cell Biology
- Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis
- Liao, C.P., Booker, R.C., Brosseau, J.P., Chen, Z., Mo, J., Tchegnon, E., Wang, Y., Clapp, D.W., Le, L.Q. Journal of Clinical Investigation. 2018 128(7): 2848-2861
- Cutaneous neurofibromas in the genomics era: current understanding and open questions
- Allaway, R., Gosline, S., Knight, P., Guinney, J., La Rosa, S., Bakker, A., Le, L.Q. British Journal of Cancer. 2018 118(12): 1539-1648.
- The Biology of Cutaneous Neurofibromas: Consensus Recommendations for Setting Research Priorities
- Brosseau J.P., Pichard D.C., Legius E., Wolkenstein P., Lavker R.M., Blakeley J.O., Riccardi V.M., Verma S., Brownell I., and Le L.Q. Neurology 2018 91(2): S14-S20
- Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway.
- Chen, Z., Mo, J., Brosseau, J.P., Shipman, T., Wang, Y., Liao, C.P., Cooper, J.M., Allaway, R.J., Gosline, S., Guinney, J., Carroll, T., Le, L.Q. Cancer Discovery. 2018 In Press.
- Identification of hair shaft progenitors that create a niche for hair pigmentation
- Liao, C.P., Booker, R.C., Morrison, S.J., Le, L.Q. Genes & Development 2017 31(8): 744-756.
- Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma
- Chen, Z., Lui, C., Patel, A., Liao, C.P., Wang, Y., Le, L.Q. Cancer Cell 2015 26(5): 695-706
- BET Bromodomain Inhibition Triggers Apoptosis of NF1-associated Malignant Peripheral Nerve Sheath Tumors through Bim Induction
- Patel, A., Liao, C.P., Chen, Z., Lui, C., Wang, Y., Le, L.Q. Cell Reports 2014 6(1): 81-92
- CXCR4/CXCL12 mediate autocrine cell cycle progression in NF1-associated malignant peripheral nerve sheath tumors
- Mo, W., Chen, J., Patel, A., Zhang, L., Chau, V., Li, Y, Cho, W., Lim, K., McKay, R., Lev, D., Le, L.Q. and Parada, L. Cell 2013 152 (5)1077-1090
- Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors
- Chau, V., Lim, S.K., Mo, W., Liu, C., Patel, A.J., McKay, R.M., Wei, S., Posner, B.A., De Brabander, J.K., Williams, N.S., Parada, L.F., Le, L.Q. Cancer Research 2013 74(2): 586-97
- Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration
- Chen, Z., Pradhan, S., Liu, C. and Le, L.Q. Stem Cells 2012 30 (10) 2261-2270.
Honors & Awards
- Elected to membership in the American Society for Clinical Investigation (ASCI)
- Thomas L. Shields, M.D. Endowed Professorship in Dermatology
- Elisabeth Reed Wagner Fund for Research and Clinical Care in Neurofibromatosis and Cardiothoracic Surgery
- U.S. Department of Defense-Investigator Initiated Research Program Awards
- European Society for Dermatological Research/Society for Investigative Dermatology Collegiality Travel Awards
- U.S. Department of Defense-Neurofibromatosis Research Program New Investigator Awards
- Victor Newcomer Award from the Pacific Dermatologic Association
- Outstanding Teaching Award from Dermatology residents
- Disease-Oriented Clinical Scholars (DOCS) Award
- Career Awards for Medical Scientists from the Burroughs Wellcome Fund
- President's Research Council Distinguished Young Researcher Award (UTSW)
- The American Academy of Dermatology Young Investigator Award
- The Dermatology Foundation Physician Scientist Career Development Award
- American Society for Clinical Investigation (ASCI) (2015)
- American Association for Cancer Research (AACR) (2013)
- Leaders Society - Dermatology Foundation (2013)
- Texas Dermatological Society
- The American Academy of Dermatology
- The Society for Investigative Dermatology
- UCLA Association of Chemists and Biochemists