Dr. Xiankai Sun obtained his B.S. in Chemistry from Wuhan University in China and Ph.D. in Inorganic Chemistry on design and synthesis of supramolecular clusters with pre-designed symmetries (Advisor: Prof. Edward H. Wong) from University of New Hampshire (Durham, NH). After three years of postdoctoral training under the mentorship of Prof. Michael J. Welch and Prof. Carolyn J. Anderson and then a short junior faculty stay at Washington University School of Medicine in St. Louis, he joined the faculty of University of Texas Southwestern Medical Center in 2004, where he is now a tenured professor of the Southwestern Graduate School on the Graduate Program of Biomedical Engineering as well as the Graduate Tracks of Biomedical Molecular Imaging and Nanomedicine.
Dr. Sun’s expertise is in the design and synthesis of molecular imaging probes and therapeutic agents for various diseases. Funded by NIH, DOD, and CPRIT, his research projects focus on metabolic imaging with radioisotopomers and developing novel biocompatible scaffolds to enable multipresentation of molecular functionalities for detection and intervention of disease states.
Endowed with the Dr. Jack Krohmer Professorship in Radiation Physics, Dr. Sun serves as the Director of the Cyclotron and Radiochemistry Program at UT Southwestern with the mission to make novel and investigational radiotracers available for preclinical, translational, and clinical research with positron emission tomography (PET). The goal is to positively impact the patient-care outcome in North Texas through the implementation of cutting-edge hybrid imaging methodologies of PET with magnetic resonance imaging (MRI) in adults and children. In addition, Dr. Sun co-directs the Preclinical Nuclear Imaging Laboratory with Dr. Orhan K. Öz in Radiology, which is equipped with state-of-the-art small animal imaging scanners (Siemens Inveon PET/CT Multimodality System and BioScan NanoSPECT/CT Plus System) and analytical instruments for molecular imaging studies in diseased animal models.
- Graduate School
- University of New Hampshire (2000), Chemistry
- Design and synthesis of novel imaging probes for cancer and diabetes
- Developing multimodality imaging methods to noninvasively and longitudinally monitor drug delivery and treatment efficacy
- Near-Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics.
- Zhou C, Hao G, Thomas P, Liu J, Yu M, Sun S, Oz OK, Sun X, Zheng J Angew. Chem. Int. Ed. Engl. 2012 Sep
- Antitumor activity and molecular dynamics simulations of paclitaxel-laden triazine dendrimers.
- Lim J, Lo ST, Hill S, Pavan GM, Sun X, Simanek EE Mol. Pharm. 2012 Mar 9 3 404-12
- Multivalent Bifunctional Chelator Scaffolds for Gallium-68 Based Positron Emission Tomography Imaging Probe Design: Signal Amplification via Multivalency.
- Singh AN, Liu W, Hao G, Kumar A, Gupta A, O¨z OK, Hsieh JT, Sun X Bioconjugate chemistry 2011 Jul 1650-62
- Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
- Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen J, Sun X, Mickey B, Choi C, Takahashi M, Togao O, Pascual JM, Deberardinis RJ, Maher EA, Malloy CR, Bachoo RM NMR in biomedicine 2012 Mar
- Imaging Copper Metabolism Imbalance in Atp7b (-/-) Knockout Mouse Model of Wilson's Disease with PET-CT and Orally Administered (64)CuCl (2).
- Peng F, Lutsenko S, Sun X, Muzik O Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011 Dec
- Recent advances in copper radiopharmaceuticals.
- Hao G, Singh AN, Oz OK, Sun X Curr Radiopharm 2011 Apr 4 2 109-21
- Luminescent gold nanoparticles with efficient renal clearance.
- Zhou C, Long M, Qin Y, Sun X, Zheng J Angew. Chem. Int. Ed. Engl. 2011 Mar 50 14 3168-72
- Transplantation of mesenchymal stem cells from young donors delays aging in mice.
- Shen J, Tsai YT, Dimarco NM, Long MA, Sun X, Tang L Sci Rep 2011 1 67
- PET with non-standard nuclides.
- Hao G, Singh AN, Liu W, Sun X Curr Top Med Chem 2010 10 11 1096-112
Honors & Awards
- Translational Image of the Year
7th Annual Preclinical Image of the Year Contest (Siemens) (2010)
- Pilot Research Award
Society of Nuclear Medicine (2005)
- Gloria and Robert Lyle Award
University of New Hampshire (1998)
- Department of Radiology and Advanced Imaging Research Center, UT Southwestern (2012)
- Department of Radiology and Advanced Imaging Research Center, UT Southwestern (2004-2012)
- Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, MO (2003-2004)