Vishal Patel, M.D.

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Vishal Patel, MBBS, is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Nephrology.

Originally from India, Dr. Patel obtained his medical degree from P S Medical College in India and completed internal medicine residency training at Northwestern University in Chicago. He then completed advanced training through a clinical nephrology fellowship at UT Southwestern Medical Center. Following his clinical training, he studied kidney genetics and primary cilia biology as an NIH-funded Physician-Scientist trainee at UT Southwestern.

Certified by the American Board of Internal Medicine in nephrology, Dr. Patel joined the UT Southwestern faculty in 2008 as an Assistant Instructor. He was promoted to Assistant Professor in 2009 and then Assistant Professor tenure-accruing in 2010. He became an Associate Professor with Tenure in 2018.

Dr. Patel's research interests include polycystic kidney disease, RNA therapeutics, and RNA metabolism. He has two patents for PKD treatment. He has also given lectures regionally, nationally, and internationally on PKD. He has published several research articles, reviews, and editorials on his findings.

Dr. Patel is a member of the American Society of Nephrology.

Medical School

Pramukhswami Medical School, India (2000)

Internship

Mount Sinai Hospital Medical Center (2002), Internal Medicine

Residency

McGaw Medical Center of Northwestern University (2004), Internal Medicine

Fellowship

UT Southwestern Medical Center (2006), Nephrology

Research Fellowship

UT Southwestern Medical Center (2008), Research

• Kidney Development and Homeostasis
• microRNAs, ncRNAs
• mRNA translation regulation
• Polycystic Kidney Disease
• RNA metabolism
• RNA therapeutics

Featured Publications

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.

Lakhia R, Ramalingam H, Chang CM, Cobo-Stark P, Biggers L, Flaten A, Alvarez J, Valencia T, Wallace DP, Lee EC, Patel V, Nat Commun 2022 Aug 13 1 4765

A methionine-Mettl3-N⁶-methyladenosine axis promotes polycystic kidney disease.

Ramalingam H, Kashyap S, Cobo-Stark P, Flaten A, Chang CM, Hajarnis S, Hein KZ, Lika J, Warner GM, Espindola-Netto JM, Kumar A, Kanchwala M, Xing C, Chini EN, Patel V, Cell Metab 2021 Jun 33 6 1234-1247.e7

Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression.

Lakhia R, Yheskel M, Flaten A, Ramalingam H, Aboudehen K, Ferrè S, Biggers L, Mishra A, Chaney C, Wallace DP, Carroll T, Igarashi P, Patel V, JCI Insight 2020 Apr 5 7

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.

Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben S, Bentley P, Wright T, Patel V, Nat Commun 2019 Sep 10 1 4148

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism.

Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V Nat Commun 2017 Feb 8 14395

MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease.

Lakhia R, Hajarnis S, Williams D, Aboudehen K, Yheskel M, Xing C, Hatley ME, Torres VE, Wallace DP, Patel V J. Am. Soc. Nephrol. 2016 Aug 27 8 2319-30

miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.

Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P Proc. Natl. Acad. Sci. U.S.A. 2013 Jun

MicroRNAs and fibrosis.

Patel V, Noureddine L Curr. Opin. Nephrol. Hypertens. 2012 Jul 21 4 410-6

Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth.

Yheskel M, Lakhia R, Cobo-Stark P, Flaten A, Patel V Sci Rep 2019 Feb 9 1 1920

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.

Brzóska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA Kidney Int. 2016 Dec 90 6 1274-1284

• PKD Foundation Grant
  PKD Foundation (2014)
• Rising Star in Nephrology - State of Texas
  Super Doctors (2012)
• Career Development Award
  National Institute of Diabetes and Digestive and Kidney Diseases (2009)
• O'Brien Center Pilot and Feasibility Grant
  UT Southwestern (2009)
• Young Investigator Travel Award
  Southern Society for Clinical Investigation (2007)
• Chief Fellow, UT Southwestern Medical Center-Nephrology fellowship
  (2006)
• Chief Nephrology Fellow
  UT Southwestern (2005-2008)

• American Society of Nephrology (2005)