2020- present Professor, Dept. of Biochemistry, UT Southwestern

2020 - present Team leader, National Institutes for Quantum and Radiolgocal Science and Technology, Japan

2014 - 2020 Associate Professor, Dept. of Biochemistry, UT Southwestern

2010 – 2014 Assistant Professor, Dept. of Biochemistry and Internal Medicine, UT Southwestern

2004 - 2010 Assistant Professor, Dept. of Internal Medicine, UT Southwestern

1999 - 2004 Postdoctoral Fellow in Professor Ellenberger’s group, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

1998 - 1999 Postdoctoral Fellow in Professor Hakoshima’s group at Dept. of Molecular Biology, Nara Institute of Science and Technology


Graduate School
Osaka University - Japan (1994), Pharmaceutical Science
Graduate School
Unlisted - International Colle (1998)

Research Interest

  • Amyloid-like fiber
  • Biochemistry
  • Fluorescent microscopy
  • Protein-protein and protein-RNA/DNA interaction
  • RNA granules
  • RNA regulation
  • X-ray crystallography


Featured Publications LegendFeatured Publications

Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.
Yang YS, Kato M, Wu X, Litsios A, Sutter BM, Wang Y, Hsu CH, Wood NE, Lemoff A, Mirzaei H, Heinemann M, Tu BP, Cell 2019 Apr 177 3 697-710.e17
Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers.
Murray DT, Zhou X, Kato M, Xiang S, Tycko R, McKnight SL Proc. Natl. Acad. Sci. U.S.A. 2018 10 115 42 E9782-E9791
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, Murray ME, Kato M, Fryer JD, Petrucelli L, Zinman L, Weintraub S, Mesulam M, Keith J, Zivkovic SA, Hirsch-Reinshagen V, Roos RP, Züchner S, Graff-Radford NR, Petersen RC, Caselli RJ, Wszolek ZK, Finger E, Lippa C, Lacomis D, Stewart H, Dickson DW, Kim HJ, Rogaeva E, Bigio E, Boylan KB, Taylor JP, Rademakers R Neuron 2017 Aug 95 4 808-816.e9
Cross-? polymerization and hydrogel formation by low-complexity sequence proteins.
Kato M, Lin Y, McKnight SL Methods 2017 Jun

Honors & Awards

  • HFSP Young Investigators Award
  • 20th International Union of Biochemistry and Molecular Biology (IUBMB) congress Young Scientist Program
  • Uehara Memorial Foundation
  • Japan Society for the Promotion of Science for Abroad
  • Japan Society for the Promotion of Science for Young Scientists