Bret Evers, M.D., Ph.D.

Fellowship

UT Southwestern Medical Center 2017, Ophthalmic Pathology

Fellowship

UT Southwestern Medical Center 2017, Ophthalmic Pathology

Medical School

UT Southwestern Medical Center (2012)

Other Post Graduate Training

UT Southwestern Medical School (2012)

Graduate School

UT Southwestern Medical School (2012), Medical Scientist Training Program

Residency

UT Southwestern Medical Center (2014), Anatomic Pathology

Fellowship

UT Southwestern Medical Center (2016), Neuropathology

• Alzheimer disease
• Analysis of mouse phenotypes
• Comparative histopathology
• Frontotemporal lobar degeneration (FTLD)
• Lipid biology and lipidomics
• Medical and graduate student education
• Neurodegeneration
• Neuropathology
• Ophthalmic pathology

Featured Publications

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R Acta Neuropathol. 2019 Feb

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R Lancet Neurol 2018 Jun 17 6 548-558

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.

Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Invest. Dermatol. 2010 May 130 5 1237-48

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Clin. Invest. 2006 Sep 116 9 2356-65

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS J. Clin. Invest. 2005 Sep 115 9 2489-98

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.

Jones BT, Han J, Zhang H, Hammer RE, Evers BM, Rakheja D, Acharya A, Mendell JT, Genes Dev 2023 Aug

Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC).

Shariff M, Dobariya A, Albaghdadi O, Awkal J, Moussa H, Reyes G, Syed M, Hart R, Longfellow C, Douglass D, El Ahmadieh TY, Good LB, Jakkamsetti V, Kathote G, Angulo G, Ma Q, Brown R, Dunbar M, Shelton JM, Evers BM, Patnaik S, Hoffmann U, Hackmann AE, Mickey B, Peltz M, Jessen ME, Pascual JM, Sci Rep 2023 Aug 13 1 13942

LY6E is a pan-coronavirus restriction factor in the respiratory tract.

Mar KB, Wells AI, Caballero Van Dyke MC, Lopez AH, Eitson JL, Fan W, Hanners NW, Evers BM, Shelton JM, Schoggins JW, Nat Microbiol 2023 Jul

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.

Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE, JCI Insight 2023 Apr 8 8

 Featured Books

Mass effect and edema. In Neuropathologic and Neuroradiologic Correlations: A differential diagnostic text and atlas

Evers, B., Danielsen, T., and Kumar, M. (2017). Cambridge, UK, Cambridge University Press

• Carl B. and Florence E. King Foundation Endowed Fund in Alzheimer’s Disease Research Award
  (2015-2017)
• Vernie A. Stembridge, M.D., Scholarship Award in Pathology (UT Southwestern)
  (2012)
• Distinguished Biochemistry Research Scholar (Texas A&M University)
  (2004)
• Barry M. Goldwater Scholar
  (2002)
• Bruce D. Fallis, M.D., Resident Award for Teaching (UT Southwestern)
  2013 and 2014
• Commencement Marshal for the Medical School Classes of 2022 and 2023
  
• Outstanding Teacher Award (UT Southwestern Medical School)
  2017, 2018, 2019, 2020, 2021, and 2022
• UT Southwestern Academy of Teachers (SWAT) Outstanding Biomedical Science Educator
  2018 and 2022

• American Association of Neuropathologists (2014)
• Phi Beta Kappa (2004)
• Sigma Xi (2004)
• Verhoeff-Zimmerman Society (2019)