Igor Butovich, Ph.D. Titles and Appointments Associate Professor School Medical School Department Ophthalmology Education Graduate School Taras Shevchenko National Univ (1981), Biochemistry Graduate School Taras Shevchenko National Univ (1981), Biology Graduate School National Academy of Sciences (1985), Chemistry Graduate School National Academy of Sciences (1985), Enzymology Research Interest Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa Chemistry, Biochemistry, and Biophysics of Lipids Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum Drug Discovery Enzymology Genomics and Metabolomics of the Eye and Adnexa Meibomian Gland Studies Publications Abnormal meibum is associated with SREBF1 mutation and IFAP Syndrome-2 Butovich IA, Schatz M, Saboo US, Wojtowicz JC, Johnson DA Experimental Eye Research 2026 Jan 262 Lipid Composition and Thermotropic Properties of Meibum of Animal Models and Humans with Meibomian Gland Dysfunction Butovich IA, Wojtowicz JC, Wilkerson A, Yuksel S International journal of molecular sciences 2025 Dec 26 Aging Affects Lipid Homeostasis in Lacrimal Glands by Upregulating Lipogenesis and Changing Its Specificity Yuksel S, Kumar P, Krenz SE, Scholand KK, Yu Z, Ivanova A, Makarenkova HP, Hamm-Alvarez SF, Butovich IA, De Paiva CS Investigative Ophthalmology and Visual Science 2025 Oct 66 Comparative Analysis of Age-Associated Changes in Meibum Composition, Distribution, and Function in Mice With Altered Hyaluronan Expression Verma S, Guevara Montoya PA, Sun M, Puri S, Yuksel S, Wilkerson A, Gesteira TF, Butovich IA, Coulson-Thomas VJ Investigative Ophthalmology and Visual Science 2025 Jul 66 Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis Yuksel S, Butovich IA Journal of Biological Chemistry 2025 Jul 301 Meibomian gland lipid alterations and ocular surface sequela in Awat2 knockout murine model of meibomian gland dysfunction and evaporative dry eye disease Hisey EA, Wong S, Park S, Gamarra KA, Adelman SA, Knickelbein KE, Quan M, Ferneding MH, McCorkell M, Daley N, Ureno V, Le S, Ardon M, Williams L, Puentes B, Bowman M, Motta MJ, Pham HQ, Wilkerson A, Yuksel S, Jester JV, Thomasy SM, Morgan JT, Butovich IA, Leonard BC Ocular Surface 2024 Oct 34 489-503 Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology Liu Y, Butovich IA, Garreis F, Zahn I, Scholz M, Gaffling S, Jabari S, Dietrich J, Paulsen F International journal of molecular sciences 2024 Mar 25 Physiological Effects of Soat1 Inactivation on Homeostasis of the Mouse Ocular Surface Wilkerson A, Yuksel S, Acharya R, Butovich IA Investigative Ophthalmology and Visual Science 2024 65 Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C Communications Biology 2023 Dec 6 Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EM, Butovich IA, Beutler BA, Ufret-Vincenty RL Communications Biology 2023 Dec 6 Results 1-10 of 111 1 2 3 4 5 Next Last Honors & Awards Current NIH awardR01EY027349 (2017-2026) NIH R01 research awards (recent)R01EY019480; R01EY024324 (2010-2021) The Royal Society of Medicine, London, United KingdomOverseas Fellow (2010) National Academy of Sciences, UkraineSenior Research Fellow, Bioorganic Chemistry (1997) Professional Associations/Affiliations Association for Research in Vision and Ophthalmology (ARVO) (2005) International Society for Eye Research (ISER) (2014) The American Society for Biochemistry and Molecular Biology (2022)
