Igor Butovich, Ph.D.

• Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa
• Chemistry, Biochemistry, and Biophysics of Lipids
• Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum
• Drug Discovery
• Enzymology
• Genomics and Metabolomics of the Eye and Adnexa
• Meibomian Gland Studies

 Featured Publications

Physiological Effects of Soat1 Inactivation on Homeostasis of the Mouse Ocular Surface.

Wilkerson A, Yuksel S, Acharya R, Butovich IA, Invest Ophthalmol Vis Sci 2024 Jul 65 8 2

Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.

Butovich IA, Wilkerson A, Yuksel S, Int J Mol Sci 2023 Aug 24 17

Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis.

Butovich IA, Wilkerson A, Goggans KR, Belyaeva OV, Kedishvili NY, Yuksel S, J Biol Chem 2023 Apr 104725

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition.

Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C, Commun Biol 2023 Mar 6 1 282

Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer LC-MS/MS study.

Butovich I, Yuksel S, Wilkerson A, J Biol Chem 2023 Feb 103046

Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.

Butovich IA, Wilkerson A, Int J Mol Sci 2022 Jul 23 14

Effects of Aging on Human Meibum.

Butovich IA, Suzuki T, Invest Ophthalmol Vis Sci 2021 Sep 62 12 23

Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.

Butovich IA, Wilkerson A, Yuksel S, J Steroid Biochem Mol Biol 2021 Apr 211 105894

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.

Wilkerson A, Bhat N, Quoc Hai Pham H, Yuksel S, Butovich I, FASEB J 2021 Feb 35 2 e21327

Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands.

Butovich IA, Suzuki T, Exp Eye Res 2020 Oct 199 108189

• Current NIH award
  R01EY027349 (2017-2026)
• NIH R01 research awards (recent)
  R01EY019480; R01EY024324 (2010-2021)
• The Royal Society of Medicine, London, United Kingdom
  Overseas Fellow (2010)
• National Academy of Sciences, Ukraine
  Senior Research Fellow, Bioorganic Chemistry (1997)

• Association for Research in Vision and Ophthalmology (ARVO) (2005)
• International Society for Eye Research (ISER) (2014)
• The American Society for Biochemistry and Molecular Biology (2022)