Igor Butovich, Ph.D.

Graduate School

National Academy of Sciences , Enzymology

Graduate School

Taras Shevchenko National Univ , Biology

Graduate School

Taras Shevchenko National Univ , Biochemistry

Graduate School

National Academy of Sciences (1985), Chemistry

• Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa
• Chemistry, Biochemistry, and Biophysics of Lipids
• Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum
• Drug Discovery
• Enzymology
• Genomics and Metabolomics of the Eye and Adnexa
• Meibomian Gland Studies

Featured Publications

Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer LC-MS/MS study.

Butovich I, Yuksel S, Wilkerson A, J Biol Chem 2023 Feb 103046

Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.

Butovich IA, Wilkerson A, Int J Mol Sci 2022 Jul 23 14

Effects of Aging on Human Meibum.

Butovich IA, Suzuki T, Invest Ophthalmol Vis Sci 2021 Sep 62 12 23

Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.

Butovich IA, Wilkerson A, Yuksel S, J Steroid Biochem Mol Biol 2021 Apr 211 105894

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.

Wilkerson A, Bhat N, Quoc Hai Pham H, Yuksel S, Butovich I, FASEB J 2021 Feb 35 2 e21327

Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands.

Butovich IA, Suzuki T, Exp Eye Res 2020 Oct 199 108189

Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis.

Butovich IA, Bhat N, Wojtowicz JC, Int J Mol Sci 2019 Sep 20 18

On the pivotal role of Elovl3/ELOVL3 in meibogenesis and ocular physiology of mice.

Butovich IA, Wilkerson A, Bhat N, McMahon A, Yuksel S, FASEB J. 2019 Jun fj201900725R

Effects of sex (or lack thereof) on meibogenesis in mice (Mus musculus): Comparative evaluation of lipidomes and transcriptomes of male and female tarsal plates.

Butovich IA, McMahon A, Wojtowicz JC, Bhat N, Wilkerson A, Ocul Surf 2019 Mar

Meibomian glands, meibum, and meibogenesis.

Butovich IA Exp. Eye Res. 2017 Jun

• Current NIH award
  R01EY027349 (2017-2026)
• NIH R01 research awards (recent)
  R01EY019480; R01EY024324 (2010-2021)
• The Royal Society of Medicine, London, United Kingdom
  Overseas Fellow (2010)
• National Academy of Sciences, Ukraine
  Senior Research Fellow, Bioorganic Chemistry (1997)

• The American Society for Biochemistry and Molecular Biology (2022)
• International Society for Eye Research (ISER) (2014)
• Association for Research in Vision and Ophthalmology (ARVO) (2005)