
Igor Butovich, Ph.D.
Associate Professor
School Medical School
Department Ophthalmology
Graduate Programs Biological Chemistry
Biography
Education
- Graduate School
- Taras Shevchenko National Univ (1981), Biology
- Graduate School
- Taras Shevchenko National Univ (1981), Biochemistry
- Graduate School
- National Academy of Sciences (1985), Enzymology
- Graduate School
- National Academy of Sciences (1985), Chemistry
Research Interest
- Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa
- Chemistry, Biochemistry, and Biophysics of Lipids
- Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum
- Drug Discovery
- Enzymology
- Genomics and Metabolomics of the Eye and Adnexa
- Meibomian Gland Studies
Publications
Featured Publications
- Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis.
- Butovich IA, Wilkerson A, Goggans KR, Belyaeva OV, Kedishvili NY, Yuksel S, J Biol Chem 2023 Apr 104725
- Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition.
- Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C, Commun Biol 2023 Mar 6 1 282
- Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer LC-MS/MS study.
- Butovich I, Yuksel S, Wilkerson A, J Biol Chem 2023 Feb 103046
- Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.
- Butovich IA, Wilkerson A, Int J Mol Sci 2022 Jul 23 14
- Effects of Aging on Human Meibum.
- Butovich IA, Suzuki T, Invest Ophthalmol Vis Sci 2021 Sep 62 12 23
- Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.
- Butovich IA, Wilkerson A, Yuksel S, J Steroid Biochem Mol Biol 2021 Apr 211 105894
- Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.
- Wilkerson A, Bhat N, Quoc Hai Pham H, Yuksel S, Butovich I, FASEB J 2021 Feb 35 2 e21327
- Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands.
- Butovich IA, Suzuki T, Exp Eye Res 2020 Oct 199 108189
- Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis.
- Butovich IA, Bhat N, Wojtowicz JC, Int J Mol Sci 2019 Sep 20 18
- On the pivotal role of Elovl3/ELOVL3 in meibogenesis and ocular physiology of mice.
- Butovich IA, Wilkerson A, Bhat N, McMahon A, Yuksel S, FASEB J. 2019 Jun fj201900725R
Honors & Awards
- Current NIH award
R01EY027349 (2017-2026) - NIH R01 research awards (recent)
R01EY019480; R01EY024324 (2010-2021) - The Royal Society of Medicine, London, United Kingdom
Overseas Fellow (2010) - National Academy of Sciences, Ukraine
Senior Research Fellow, Bioorganic Chemistry (1997)
Professional Associations/Affiliations
- Association for Research in Vision and Ophthalmology (ARVO) (2005)
- International Society for Eye Research (ISER) (2014)
- The American Society for Biochemistry and Molecular Biology (2022)