Nikhil Munshi, M.D., Ph.D.

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Nikhil Munshi, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center. and a member of the Division of Cardiology, where he serves as the Assistant Director of the Physician Scientist Training Program. He specializes in general cardiology.

Originally from Palo Alto, California, Dr. Munshi holds bachelor's degrees in biomedical engineering and molecular biology from the University of California-San Diego, where he graduated summa cum laude. He earned his medical degree and his doctorate in biochemistry at Columbia University in New York. He completed internal medicine residency training and advanced training through a fellowship in cardiology at UT Southwestern. He then completed additional advanced training through postdoctoral fellowships in molecular cardiology and developmental biology at Columbia and UT Southwestern.

Certified by the American Board of Internal Medicine in cardiology, Dr. Munshi joined the UT Southwestern faculty in 2011. 

Dr. Munshi’s research focuses on cardiac rhythms in health and disease and has led to frequent publication in peer-reviewed journals, as well as editorials, reviews, and book chapters. He is also a frequent speaker both regionally and nationally. 

Dr. Munshi is a member of many professional societies, including the American College of Cardiology, the American Heart Association, the American Medical Association, the Dallas County Medical Society, and the Texas Medical Association.

At UT Southwestern, Dr. Munshi is on the Steering Committee for the Genes, Development, and Disease Graduate Program, as well as the Lab Website Advisory Committee and the Internal Medicine Physician-Scientist Development Committee.

During his fellowship at UT Southwestern, he received the Joanne McWhorter Award for Excellence in Clinical Cardiology. He was named a Disease Oriented Clinical Scholar in 2011.

Graduate School

Columbia University College of Physicians and Surgeons (2001), Biochemistry

Medical School

Columbia University Medical Center (2003)

Internship

UT Southwestern Medical Center (2005), Internal Medicine

Residency

UT Southwestern Medical Center (2006), Internal Medicine

Fellowship

UT Southwestern Medical Center (2011), Cardiology

• Cardiac Development
• Cardiac Dysrhythmia
• Regeneration
• Reprogramming
• Single-cell genomics
• Transcriptional Regulation

Featured Publications

Inducible cardiomyocyte injury within the atrioventricular conduction system uncovers latent regenerative capacity in mice.

Wang L, Bhakta M, Fernandez-Perez A, Munshi NV, J Clin Invest 2021 Oct 131 19

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.

Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV Sci Rep 2019 Feb 9 1 2106

Hand2 selectively reorganizes chromatin accessibility to induce pacemaker-like transcriptional reprogramming

Fernandez-Perez A, Sathe AA,Bhakta M,Leggett K,Xing C,Munshi NV Cell Rep 2019 27 1-16

Rational reprogramming of cellular states by combinatorial perturbation

Duan J, Li B, Bhakta M, Xie S, Zhou P, Munshi NV*, Hon GC* Cell Rep 2019

Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.

Nam YJ, Lubczyk C, Bhakta M, Zang T, Fernandez-Perez A, McAnally J, Bassel-Duby R, Olson EN, Munshi NV Development 2014 Oct

Development of the Cardiac Conduction System.

Bhattacharyya S, Munshi NV, Cold Spring Harb Perspect Biol 2020 Jan

pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.

Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV Dev. Dyn. 2019 Feb 248 2 173-188

PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues.

Bhattacharyya S, Sathe AA, Bhakta M, Xing C, Munshi NV, PLoS ONE 2019 14 4 e0214677

Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device.

Lam KH, Fernandez-Perez A, Schmidtke DW, Munshi NV Biomed Microdevices 2018 Jun 20 3 52

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ Sci Rep 2018 Jan 8 1 1258

• Career Award for Medical Scientists (CAMS) - Burroughs Wellcome Foundation
  (2011)
• Disease Oriented Clinical Scholar (DOCS) Award
  (2011)
• Jo Ann McWhorter Award for Clinical Cardiology
  (2011)
• Young Investigator Award for Basic Science - American Association of Indian Cardiologists
  (2011)
• Fellows Basic Science Winner - Northwestern Cardiovascular Young Investigators’ Forum
  (2008)

• Alpha Omega Alpha (2006)
• American College of Cardiology (2006)
• American Heart Association (2011)
• American Medical Association (2004)
• Dallas County Medical Society (2011)
• Texas Medical Association (2011)