Jun-Shen Huang, Ph.D.
Associate Professor

Undergraduate

National Taiwan University , Chemistry

Graduate School

University of California-San D (1997)

• Cancer
• Cytokine receptor
• Hematopoiesis
• Signal transduction
• Structure-function analysis of protein

Featured Publications

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.

Zhang LS, Kang X, Lu J, Zhang Y, Wu X, Wu G, Zheng J, Tuladhar R, Shi H, Wang Q, Morlock L, Yao H, Huang LJ, Maire P, Kim J, Williams N, Xu J, Chen C, Zhang CC, Lum L EBioMedicine 2019 Jan 39 145-158

Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC Am. J. Physiol. Renal Physiol. 2018 04 314 4 F501-F516

Dynamic Change of Transcription Pausing through Modulating NELF Protein Stability Regulates Granulocytic Differentiation.

Liu X, Gogate AA, Tastemel M, Malladi VS, Yao H, Nguyen K, Huang LJ, Bai X Blood Adv 2017 Aug 1 18 1358-1367

Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.

Yao H, Ma Y, Hong Z, Zhao L, Monaghan SA, Hu MC, Huang LJ Leukemia 2017 Jan

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.

Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC Nat. Med. 2016 Dec

Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 aC helix.

Leroy E, Dusa A, Colau D, Motamedi A, Cahu X, Mouton C, Huang LJ, Shiau AK, Constantinescu SN Biochem. J. 2016 06 473 11 1579-91

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.

Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP Cell Rep 2015 Jul 12 3 371-9

Genome Editing of Mouse Fibroblasts by Homologous Recombination for Sustained Secretion of PDGF-B and Augmentation of Wound Healing

Barker, J. C., Barker, A. D., Bills, J., Huang, J., Wight-Carter, M., Delgado, I., Noble, D. L., Huang, L. J., Porteus, M. H., and Davis, K. E. Plast Reconstr Surg 2014 3 134 389e-401e

Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products.

Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco YP, Bulut GB, Ou YH, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang LJ, Lewis RE, Macmillan JB, White MA Sci Signal 2013 6 297 ra90

Cbl ubiquitination of p85 is essential for EPO-induced EPOR endocytosis.

Bulut GB, Sulahian R, Yao H, Huang LJ Blood 2013 Oct

• American Cancer Society Postdoctoral Fellowship
  (2002)
• Howard Temin Award
  (2002)
• NIH NRSA Award
  (1998)

• American Society of Hematology (2007)
• American Society of Biochemistry and Molecular Biology (2006)