Jun-Shen Huang, Ph.D.
Associate Professor

Undergraduate

National Taiwan University , Chemistry

Graduate School

University of California-San D (1997)

• Cancer
• Cytokine receptor
• Hematopoiesis
• Signal transduction
• Structure-function analysis of protein

Featured Publications

Cbl ubiquitination of p85 is essential for EPO-induced EPOR endocytosis.

Bulut GB, Sulahian R, Yao H, Huang LJ Blood 2013 Oct

Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity.

Kang CC, Huang WC, Kouh CW, Wang ZF, Cho CC, Chang CC, Wang CL, Chang TC, Seemann J, Huang LJ Integr Biol (Camb) 2013 Aug

The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.

Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW Kidney Int. 2013 May

Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.

Wan X, Ma Y, McClendon CL, Huang LJ, Huang N PLoS Comput. Biol. 2013 Apr 9 4 e1003022

Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products.

Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco YP, Bulut GB, Ou YH, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang LJ, Lewis RE, Macmillan JB, White MA Sci Signal 2013 6 297 ra90

Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor.

Bulut GB, Sulahian R, Ma Y, Chi NW, Huang LJ J. Biol. Chem. 2011 Feb 286 8 6449-57

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta.

Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN Genes Dev. 2010 Aug 24 15 1614-9

Advances in understanding the pathogenesis of primary familial and congenital polycythaemia.

Huang LJ, Shen YM, Bulut GB Br. J. Haematol. 2010 Mar 148 6 844-52

A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).

Zhao L, Ma Y, Seemann J, Huang LJ Biochem. J. 2010 Feb 426 1 91-8

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

Zhao L, Dong H, Zhang CC, Kinch L, Osawa M, Iacovino M, Grishin NV, Kyba M, Huang LJ J. Biol. Chem. 2009 Sep 284 39 26988-98

• American Cancer Society Postdoctoral Fellowship
  (2002)
• Howard Temin Award
  (2002)
• NIH NRSA Award
  (1998)

• American Society of Hematology (2007)
• American Society of Biochemistry and Molecular Biology (2006)