Li Liu, Ph.D.

Undergraduate

Inner Mongolia University (1989), Biomedical Engineering

Graduate School

Inner Mongolia University (1997), Microbiology

Graduate School

Chinese Academy of Sciences (1999), Biochemistry

Graduate School

Nankai University (2002), Microbiology

• Bioluminescent, Fluorescent and MSOT Imaging in vivo
• Lung Cancer therapy
• Report Genes and gene reporters application in vivo

Featured Publications

Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment.

Guo Y, Wang H, Gerberich JL, Odutola SO, Charlton-Sevcik AK, Li M, Tanpure RP, Tidmore JK, Trawick ML, Pinney KG, Mason RP, Liu L, Cancers (Basel) 2021 Sep 13 19

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Zhang L, Zhang K, Zhang J, Zhu J, Xi Q, Wang H, Zhang Z, Cheng Y, Yang G, Liu H, Guo X, Zhou D, Xue Z, Li Y, Zhang Q, Da Y, Liu L, Yin Z, Yao Z, Zhang R, Nat Commun 2021 07 12 1 4300

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.

Liu L, O'Kelly D, Schuetze R, Carlson G, Zhou H, Trawick ML, Pinney KG, Mason RP, Molecules 2021 Apr 26 9

Oxygen-enhanced optoacoustic tomography reveals the effectiveness of targeting heme and oxidative phosphorylation at normalizing tumor vascular oxygenation.

Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, Liu J, Campbell J, Konduri PC, Gerberich J, Garrosian M, Mason RP, Zhang L, Liu L, Cancer Res. 2020 Jun

Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity.

Xi Q, Zhang J, Yang G, Zhang L, Chen Y, Wang C, Zhang Z, Guo X, Zhao J, Xue Z, Li Y, Zhang Q, Da Y, Liu L, Yao Z, Zhang R, J Immunother Cancer 2020 Jun 8 1

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.

Kalainayakan SP, Ghosh P, Dey S, Fitzgerald KE, Sohoni S, Konduri PC, Garrossian M, Liu L, Zhang L Sci Rep 2019 Feb 9 1 1405

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells.

Dey S, Kumari S, Kalainayakan SP, Campbell J, Ghosh P, Zhou H, FitzGerald KE, Li M, Mason RP, Zhang L, Liu L Oncotarget 2018 Jan 9 3 4090-4101

Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects.

Yu M, Zhou C, Liu L, Zhang S, Sun S, Hankins JD, Sun X, Zheng J Angew. Chem. Int. Ed. Engl. 2017 Mar

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

Yan Y, Zhou K, Xiong H, Miller JB, Motea EA, Boothman DA, Liu L, Siegwart DJ Biomaterials 2017 Feb 118 84-93

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.

Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ Proc. Natl. Acad. Sci. U.S.A. 2016 Sep 113 39 E5702-10

 Featured Books

Innovative applications of reporter genes and gene reporters in prostate cancer. In Prostate Cancer Cells: Detection, Growth and Treatment

Liu L, Alhasan MK, Cui WN, Magnusson J and Mason RP (2012). NOVA Publishers

• American Association for Cancer Research
• International Association for the study of lung Cancer
• Society of Molecular Imaging
• World Association for Chinese Biomedical Engineers