Greg Fitz, M.D.

Medical School

Duke University School of Medicine (1979)

Internship

University of California at San Francisco (1980), Internal Medicine

Residency

University of California at San Francisco (1983), Internal Medicine

Fellowship

University of California at San Francisco (1985), Gastroenterology

• Biliary secretion
• Cellular mechanisms of insulin resistance
• Epithelial ion channels
• Purinergic signaling

Featured Publications

p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability.

Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG J. Clin. Invest. 2001 Nov 108 10 1495-504

Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.

Roman RM, Lomri N, Braunstein G, Feranchak AP, Simeoni LA, Davison AK, Mechetner E, Schwiebert EM, Fitz JG J. Membr. Biol. 2001 Oct 183 3 165-73

Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanism.

Kilic G, Doctor RB, Fitz JG J. Biol. Chem. 2001 Jul 276 29 26762-8

Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume.

Roman RM, Wang Y, Lidofsky SD, Feranchak AP, Lomri N, Scharschmidt BF, Fitz JG J. Biol. Chem. 1997 Aug 272 35 21970-6

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

Wang Y, Roman R, Lidofsky SD, Fitz JG Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 93 21 12020-5

Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability.

Feranchak AP, Kilic G, Wojtaszek PA, Qadri I, Fitz JG J. Biol. Chem. 2003 Nov 278 45 44632-8

Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover.

Doctor RB, Dahl R, Fouassier L, Kilic G, Fitz JG Am. J. Physiol., Cell Physiol. 2002 May 282 5 C1042-52

Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line.

Kilic G, Fitz JG J. Biol. Chem. 2002 Apr 277 14 11721-7

Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation.

Braunstein GM, Roman RM, Clancy JP, Kudlow BA, Taylor AL, Shylonsky VG, Jovov B, Peter K, Jilling T, Ismailov II, Benos DJ, Schwiebert LM, Fitz JG, Schwiebert EM J. Biol. Chem. 2001 Mar 276 9 6621-30

ClC-2 chloride channels contribute to HTC cell volume homeostasis.

Roman RM, Smith RL, Feranchak AP, Clayton GH, Doctor RB, Fitz JG Am. J. Physiol. Gastrointest. Liver Physiol. 2001 Mar 280 3 G344-53

• MERIT Award
  National Institutes of Health (2002)
• Association of American Physicians
  (2001)
• Waterman Chair in Liver Research
  (1996)
• Eugene Stead Award for Excellence in Teaching
  Duke University (1991)
• American Society for Clinical Investigation
  Best Doctors in America 2001, 2002, 2003 (0)

• American Association for the Study of Liver Disease
• American Federation for Clinical Research
• American Gastroenterological Association
• American Society for Clinical Investigation
• Association of American Physicians