Debabrata Saha, Ph.D.

Undergraduate

University of Calcutta - India (1988), Chemistry

Graduate School

University of Calcutta - India (1991), Biochemistry

Graduate School

Uni of Nebraska-Lincoln (1997), Chemistry

• Role of Cycloxygenase-2 in radiation and chemo-resistance.
• Role of small molecule inhibitors as radio-sensitizers

Featured Publications

Down-regulation of human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation.

Yun EJ, Lin CJ, Dang A, Hernandez E, Guo J, Chen WM, Allison J, Kim N, Kapur P, Brugarolas J, Wu K, He D, Lai CH, Lin H, Saha D, Baek ST, Chen BPC, Hsieh JT, Clin. Cancer Res. 2019 Apr

The effect of flow on blood oxygen level dependent (R* 2 ) MRI of orthotopic lung tumors.

Zhou H, Belzile O, Zhang Z, Wagner J, Ahn C, Richardson JA, Saha D, Brekken RA, Mason RP Magn Reson Med 2019 81 6 3787-3797

EGFR Mutations Compromise Hypoxia-associated Radiation Resistance Through Impaired Replication Fork-associated DNA Damage Repair.

Saki M, Makino H, Javvadi P, Tomimatsu N, Ding L, Clark JE, Gavin E, Takeda K, Andrews J, Saha D, Story MD, Burma S, Nirodi C Mol. Cancer Res. 2017 Aug

Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines.

Karanam NK, Srinivasan K, Ding L, Sishc B, Saha D, Story MD Cell Death Dis 2017 Mar 8 3 e2711

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging.

Zhou H, Zhang Z, Denney R, Williams JS, Gerberich J, Stojadinovic S, Saha D, Shelton JM, Mason RP Oncotarget 2017 Mar

Dual-Drug Containing Core-Shell Nanoparticles for Lung Cancer Therapy

Menon J, Kuriakose A, Iyer R, Hernandez E, Gandee L, Zhang S, Takahashi M, Zhang Z, Saha D, Nguyen K Sci Rep 2017 1 7 13249

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments.

Yu L, Shang ZF, Abdisalaam S, Lee KJ, Gupta A, Hsieh JT, Asaithamby A, Chen BP, Saha D Nucleic Acids Res. 2016 Aug

Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy.

Zhang Z, Wodzak M, Belzile O, Zhou H, Sishc B, Yan H, Stojadinovic S, Mason RP, Brekken RA, Chopra R, Story MD, Timmerman R, Saha D Radiat. Res. 2016 May

Pretreatment biopsy analysis of DAB2IP identifies subpopulation of high-risk prostate cancer patients with worse survival following radiation therapy.

Jacobs C, Tumati V, Kapur P, Yan J, Xie XJ, Hannan R, Hsieh JT, Kim DW, Saha D Cancer Med 2015 Oct

[(68) Ga]-HP-DO3A-nitroimidazole: a promising agent for PET detection of tumor hypoxia.

Wu Y, Hao G, Ramezani S, Saha D, Zhao D, Sun X, Sherry AD Contrast Media Mol Imaging 2015 Jun