Rodney E. Infante obtained his MD, PhD in 2012 from the University of Texas Southwestern Medical School where he studied intracellular lipid trafficking under the tutelage of Drs. Michael Brown and Joseph Goldstein. After completing clinical training in internal medicine at Massachusetts General Hospital, he returned to UT Southwestern for a fellowship in gastroenterology and hepatology. He has now joined the faculty in the Center for Human Nutrition with secondary appointments in the Department of Molecular Genetics and the Department of Internal Medicine. His lab is interested in the molecules and mechanisms that cause cachexia-associated adipose wasting associated with oncologic, liver, infectious, and rheumatologic diseases. By understanding the mechanisms that underlie adipose loss in cachexia, his lab plans to identify new treatments for cachexia patients while also providing insights to induce adipose loss in obesity.
- Medical School
- UT Southwestern Medical School (2012)
- Massachusetts General Hospital (2014), Internal Medicine
- UT Southwestern Medical Center (2017), Gastroenterology
- Cytokine-Associated Adipocyte Lipolysis
- Lipid Metabolsim
- JAK Inhibitors Suppress Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice.
- Arora G., Gupta A., Guo T., Gandhi A., Laine A., Williams D., Ahn C., Iyengar P., and Infante R. Journal of Cachexia, Saropenia, and Muscle Rapid Communications 2020 In Press
- Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin.
- Arora GK, Gupta A, Narayanan S, Guo T, Iyengar P, Infante RE JCI Insight 2018 Jul 3 14
- Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care.
- Gannavarapu BS, Lau SKM, Carter K, Cannon NA, Gao A, Ahn C, Meyer JJ, Sher DJ, Jatoi A, Infante R, Iyengar P J Oncol Pract 2018 Feb JOP2017025221
- Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
- Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I, Cell Metab. 2020 Apr
- Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum.
- Johnson KA, Endapally S, Vazquez DC, Infante RE, Radhakrishnan A, J. Biol. Chem. 2019 Oct
- Monitoring and Modulating Intracellular Cholesterol Trafficking Using ALOD4, a Cholesterol-Binding Protein.
- Endapally S, Infante RE, Radhakrishnan A Methods Mol. Biol. 2019 1949 153-163
- Impact of Socioeconomic Status on Pretreatment Weight Loss and Survival in Non-Small-Cell Lung Cancer.
- Lau SKM, Gannavarapu BS, Carter K, Gao A, Ahn C, Meyer JJ, Sher DJ, Jatoi A, Infante R, Iyengar P J Oncol Pract 2018 Mar JOP2017025239
- Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.
- Infante RE, Radhakrishnan A Elife 2017 Apr 6
- Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.
- Wang ML, Motamed M, Infante RE, Abi-Mosleh L, Kwon HJ, Brown MS, Goldstein JL Cell Metab. 2010 Aug 12 2 166-73
- Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells.
- Abi-Mosleh L, Infante RE, Radhakrishnan A, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 106 46 19316-21
Honors & Awards
- AGA Research Scholar Award
- Burroughs Wellcome Career Award for Medical Scientists
- UTSW President's Research Council Award
- V Foundation Scholar Award
- UTSW Hemphill-Gojer Award in Internal Medicine
- ASCB Norton B. Gilula Award
- UTSW Nominata Award