Biography

Rodney E. Infante obtained his MD, PhD in 2012 from the University of Texas Southwestern Medical School where he studied intracellular lipid trafficking under the tutelage of Drs. Michael Brown and Joseph Goldstein.  After completing clinical training in internal medicine at Massachusetts General Hospital, he returned to UT Southwestern for a fellowship in gastroenterology and hepatology.  He has now joined the faculty in the Center for Human Nutrition with secondary appointments in the Department of Molecular Genetics and the Department of Internal Medicine.  His lab is interested in the molecules and mechanisms that cause cachexia-associated adipose wasting associated with oncologic, liver, infectious, and rheumatologic diseases. By understanding the mechanisms that underlie adipose loss in cachexia, his lab plans to identify new treatments for cachexia patients while also providing insights to induce adipose loss in obesity.

Education

Medical School
UT Southwestern Medical School (2012)
Residency
Massachusetts General Hospital (2014), Internal Medicine
Fellowship
UT Southwestern Medical Center (2017), Gastroenterology

Research Interest

  • Cachexia
  • Cytokine-Associated Adipocyte Lupolysis
  • Lipid Metabolsim
  • Obesity

Publications

Featured Publications LegendFeatured Publications

Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin.
Arora GK, Gupta A, Narayanan S, Guo T, Iyengar P, Infante RE JCI Insight 2018 Jul 3 14
Impact of Socioeconomic Status on Pretreatment Weight Loss and Survival in Non-Small-Cell Lung Cancer.
Lau SKM, Gannavarapu BS, Carter K, Gao A, Ahn C, Meyer JJ, Sher DJ, Jatoi A, Infante R, Iyengar P J Oncol Pract 2018 Mar JOP2017025239
Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care.
Gannavarapu BS, Lau SKM, Carter K, Cannon NA, Gao A, Ahn C, Meyer JJ, Sher DJ, Jatoi A, Infante R, Iyengar P J Oncol Pract 2018 Feb JOP2017025221
Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.
Infante RE, Radhakrishnan A Elife 2017 Apr 6
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.
Wang ML, Motamed M, Infante RE, Abi-Mosleh L, Kwon HJ, Brown MS, Goldstein JL Cell Metab. 2010 Aug 12 2 166-73
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells.
Abi-Mosleh L, Infante RE, Radhakrishnan A, Goldstein JL, Brown MS Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 106 46 19316-21
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
Kwon HJ, Abi-Mosleh L, Wang ML, Deisenhofer J, Goldstein JL, Brown MS, Infante RE Cell 2009 Jun 137 7 1213-24
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.
Infante RE, Wang ML, Radhakrishnan A, Kwon HJ, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2008 Oct 105 40 15287-92
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.
Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL J. Biol. Chem. 2008 Jan 283 2 1052-63
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop.
Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS J. Biol. Chem. 2008 Jan 283 2 1064-75