Rodney E. Infante obtained his MD, PhD in 2012 from the University of Texas Southwestern Medical School where he studied intracellular lipid trafficking under the tutelage of Drs. Michael Brown and Joseph Goldstein. After completing clinical training in internal medicine at Massachusetts General Hospital, he returned to UT Southwestern for a fellowship in gastroenterology and hepatology. He has now joined the faculty in the Center for Human Nutrition with secondary appointments in the Department of Molecular Genetics and the Department of Internal Medicine. His lab is interested in the molecules and mechanisms that cause cachexia-associated adipose wasting associated with oncologic, liver, infectious, and rheumatologic diseases. By understanding the mechanisms that underlie adipose loss in cachexia, his lab plans to identify new treatments for cachexia patients while also providing insights to induce adipose loss in obesity.
- Medical School
- UT Southwestern Medical School (2012)
- Massachusetts General Hospital (2014), Internal Medicine
- UT Southwestern Medical Center (2017), Gastroenterology
- Cytokine-Associated Adipocyte Lipolysis
- Lipid Metabolsim
- LIFR-a-dependent adipocyte signaling in obesity limits adipose expansion contributing to fatty liver disease.
- Guo T, Gupta A, Yu J, Granados JZ, Gandhi AY, Evers BM, Iyengar P, Infante RE, iScience 2021 Mar 24 3 102227
- JAK Inhibitors Suppress Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice.
- Arora G, Gupta A, Guo T, Gandhi A, Laine A, Williams D, Ahn C, Iyengar P, Infante R, JCSM Rapid Commun 2020 Jul-Dec 3 2 115-128
- Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin.
- Arora GK, Gupta A, Narayanan S, Guo T, Iyengar P, Infante RE JCI Insight 2018 Jul 3 14
- Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care.
- Gannavarapu BS, Lau SKM, Carter K, Cannon NA, Gao A, Ahn C, Meyer JJ, Sher DJ, Jatoi A, Infante R, Iyengar P J Oncol Pract 2018 Feb JOP2017025221
- Rich NE, Iyengar P, Infante RE, Singal AG, Clin Gastroenterol Hepatol 2022 Feb
- Associations of Prior Chronic Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Glucocorticoids With Cachexia Incidence and Survival.
- Olaechea S, Gilmore A, Alvarez C, Gannavarapu BS, Infante R, Iyengar P, Front Oncol 2022 12 922418
- Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia.
- Gandhi AY, Yu J, Gupta A, Guo T, Iyengar P, Infante RE, Front Oncol 2022 12 841758
- Primary Tumor Fluorine-18 Fluorodeoxydglucose (18F-FDG) Is Associated With Cancer-Associated Weight Loss in Non-Small Cell Lung Cancer (NSCLC) and Portends Worse Survival.
- Olaechea S, Gannavarapu BS, Alvarez C, Gilmore A, Sarver B, Xie D, Infante R, Iyengar P, Front Oncol 2022 12 900712
- The influence of tumour fluorodeoxyglucose avidity and cachexia development on patient survival in oesophageal or gastroesophageal junction cancer.
- Olaechea S, Gannavarapu BS, Gilmore A, Alvarez C, Iyengar P, Infante R, JCSM Clin Rep 2021 Oct 6 4 128-136
- Cachexia is Prevalent in Patients with Hepatocellular Carcinoma and Associated with Worse Prognosis.
- Rich NE, Phen S, Desai N, Mittal S, Yopp AC, Yang JD, Marrero JA, Iyengar P, Infante RE, Singal AG, Clin Gastroenterol Hepatol 2021 Sep
Honors & Awards
- AGA Research Scholar Award
- Burroughs Wellcome Career Award for Medical Scientists
- UTSW President's Research Council Award
- V Foundation Scholar Award
- UTSW Hemphill-Gojer Award in Internal Medicine
- ASCB Norton B. Gilula Award
- UTSW Nominata Award