Amyn Habib, M.D.

Dr. Amyn Habib holds an appointment in the Department of Neurology at UT Southwestern Medical Center and is a Staff Physician at the VA North Texas Health Care System/ Dallas VA Medical Center. As a physician-scientist, Dr. Habib attends to patients with neurological disorders and also runs an active basic science research laboratory.

Research: His research interests include investigation of growth factor signaling pathways in glioblastoma and other cancers. His work has elucidated the interaction between normal and mutant epidermal growth factor receptors (EGFR) in glioblastoma.

In addition, his laboratory has identified and characterized interactions between inflammatory and oncogenic signaling pathways in cancer.  His laboratory has provided a fundamental insight in the biology of EGFR signaling by demonstrating that constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks. More recent work in his laboratory has focused on mechanisms of resistance to targeted treatment in cancer with a particular focus on glioblastoma and lung cancer and identified therapeutic approaches to overcome the resistance of glioblastoma and non-small cell lung cancer (NSCLC) to EGFR inhibition.

Additional areas of active interest in the laboratory include mechanisms that regulate the invasion and proliferation of tumor cells in glioblastoma.  His research is funded by the NIH and the Department of Veterans Affairs.

Background: He received his medical degree from Dow Medical College in Karachi, Pakistan. He did his internship at Henry Ford Hospital in Detroit, followed by a Neurology Residency at the University of Chicago Medical Center.  He then undertook research fellowships at the University of Chicago and Beth Israel Deaconess Medical Center/Harvard Medical School.  He was an Instructor of Neurology at Harvard Medical School before joining UT Southwestern.