Dr. Amyn Habib is an Associate Professor in the Department of Neurology at UT Southwestern Medical Center, and a Staff Physician at the VA North Texas Health Care System/ Dallas VA Medical Center. As a physician scientist, Dr. Habib attends to patients with neurological disorders and also runs an active basic science research laboratory.
He received his medical degree from Dow Medical College in Karachi, Pakistan. He did his internship at Henry Ford Hospital in Detroit, followed by a Neurology Residency at the University of Chicago Medical Center. He then undertook research fellowships at the University of Chicago and at Beth Israel Deaconess Medical Center/Harvard Medical School. He was an Instructor of Neurology at Harvard Medical School prior to joining UT Southwestern.
His research interests include investigation of growth factor signaling pathways in glioblastoma and other cancers. His work has elucidated the interaction between normal and mutant epidermal growth factor receptors (EGFR) in glioblastoma. In addition, his laboratory has identified and characterized interactions between inflammatory and oncogenic signaling pathways in cancer. His laboratory has provided a fundamental insight in the biology of EGFR signaling by demonstrating that constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks. More recent work in his laboratory has focused on mechanisms of resistance to targeted treatment in cancer with a particular focus on glioblastoma and lung cancer and identified therapeutic approaches to overcome the resistance of glioblastoma and non-small cell lung cancer (NSCLC) to EGFR inhibition. Additional areas of active interest in the laboratory include mechanisms that regulate the invasion and proliferation of tumor cells in glioblastoma. His research is funded by the NIH and by the Department of Veteran’s Affairs.
- Medical School
- Dow Medical College - Pakistan (1986), Medicine
- Mechanisms of resistance to targeted treatment in cancer
- Molecular Mechanisms regulating glioblastoma invasion and proliferation
- The role of inflammation in gliomagenesis
- EGFR inhibition triggers an adaptive response driven by cooptation of antiviral signaling pathways in lung cancer
- Gong K, Guo G, Panchani N, Bender M, Gerber DE, Minna JD, Fattah F, Gao B, Peyton M, Kernstine K, Mukherjee B, Burma S, Chiang CM, Zhang S, Sathe AA, Xing C, Dao KH, Zhao D, Akbay EA, and Habib AA*. Nat. Cancer 2020 1, 394
- Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma
- Guo G, Gong K, Puliyapaddamba VT, Pan E, Mukherjee B, Damanwalla Z, Bharia S, Hatanpaa KJ, Zhao D, Burma S, and Habib AA Neuro Oncol. 2019 Nov 8;10(1):5108
- TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
- Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA J Clin Invest. 2018 Jun 1;128(6):2500-2518
- A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
- Guo G, Gong K, Ali S, Ali N, Shallwani S, Hatanpaa KJ, Pan E, Mickey B, Burma S, Wang DH, Kesari S, Sarkaria JN, Zhao D, Habib AA Nat. Neurosci. 2017 Aug;20(8):1074-1084. doi: 10.1038/nn.4584.
- Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks
- Chakraborty S, Li L, Puliyappadamba VT, Guo G, Hatanpaa KJ, Mickey B, Souza R, Vo P, Herz J, Chen MR, Boothman DA, Pandita TK, Wang DH, Sen GC, Habib AA. Nature Communications 2014 Dec 15, 2014. DOI:10.1038/ncomms86811 1-15
- Opposing effect of EGFRWT on EGFRvIII-mediated NF-?B activation with RIP1 as a cell death switch.
- Puliyappadamba VT, Chakraborty S, Chauncey SS, Li L, Hatanpaa KJ, Mickey B, Noorani S, Shu HK, Burma S, Boothman DA, Habib AA Cell Rep 2013 Aug 4 4 764-75
- An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases.
- Liu Y, Crowe WN, Wang L, Lu Y, Petty WJ, Habib AA, Zhao D, Nat Commun 2019 Nov 10 1 5108
- Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas.
- Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S, Cancer Res. 2019 May
- MRI Evaluation of the effects of Whole Brain Radiotherapy on Breast Cancer Brain Metastasis.
- Crowe W, Wang L, Zhang Z, Varagic J, Bourland JD, Chan MD, Habib AA, Zhao D Int. J. Radiat. Biol. 2018 Nov 1-27
- Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas.
- Richardson TE, Sathe AA, Kanchwala M, Jia G, Habib AA, Xiao G, Snuderl M, Xing C, Hatanpaa KJ J. Neuropathol. Exp. Neurol. 2018 May
Honors & Awards
- Clinical Investigator Award
National Cancer Institute (1999)