
Lora Hooper, Ph.D.
Professor & Chair
Endowed Title Jonathan W. Uhr, M.D. Distinguished Chair in Immunology; Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell
School Medical School
Department Immunology | Center for Genetics of Host Defense | Microbiology
Graduate Programs Immunology, Molecular Microbiology
Education
- Undergraduate
- Rhodes College , Biology
- Graduate School
- Washington University (1996), Molecular & Cell Biology
Research Interest
- Carbohydrate-Lectin Interactions
- Circadian regulation of immunity
- Host-microbial interactions
- Innate immunity
- Mucosal immunology
Publications
Featured Publications
- Antibacterial membrane attack by a pore-forming intestinal C-type lectin.
- Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV Nature 2013 Nov
- TH17 cell differentiation is regulated by the circadian clock.
- Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV Science 2013 Nov 342 6159 727-30
- Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria.
- Benjamin JL, Sumpter R, Levine B, Hooper LV Cell Host Microbe 2013 Jun 13 6 723-34
- A composite bacteriophage alters colonization by an intestinal commensal bacterium.
- Duerkop BA, Clements CV, Rollins D, Rodrigues JL, Hooper LV Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 43 17621-6
- The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.
- Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV Science 2011 Oct 334 6053 255-8
- Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.
- Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV Proc. Natl. Acad. Sci. U.S.A. 2008 Dec 105 52 20858-63
- Symbiotic bacteria direct expression of an intestinal bactericidal lectin.
- Cash HL, Whitham CV, Behrendt CL, Hooper LV Science 2006 Aug 313 5790 1126-30
- Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.
- Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y Genes Dev. 2012 Jun 26 12 1306-11
- Interactions between the microbiota and the immune system.
- Hooper LV, Littman DR, Macpherson AJ Science 2012 Jun 336 6086 1268-73
- Epithelial antimicrobial defence of the skin and intestine.
- Gallo RL, Hooper LV Nat. Rev. Immunol. 2012 12 7 503-16
Honors & Awards
- The Academy of Medicine, Engineering, and Science of Texas, Edith and Peter ODonnell Award in Medicine
(2013) - Howard Hughes Medical Institute
(2008) - Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
(2007) - U.T. Southwestern Endowed Scholar in Biomedical Research
(2003) - Burroughs Wellcome Career Award in Biomedical Sciences
(2000) - Genzyme Award for Thesis Research in Glycobiology
(1996)