Lora Hooper, Ph.D.

Undergraduate

Rhodes College , Biology

Graduate School

Washington University (1996), Molecular & Cell Biology

• Carbohydrate-Lectin Interactions
• Circadian regulation of immunity
• Host-microbial interactions
• Innate immunity
• Mucosal immunology

Featured Publications

Antibacterial membrane attack by a pore-forming intestinal C-type lectin.

Mukherjee S, Zheng H, Derebe MG, Callenberg KM, Partch CL, Rollins D, Propheter DC, Rizo J, Grabe M, Jiang QX, Hooper LV Nature 2013 Nov

TH17 cell differentiation is regulated by the circadian clock.

Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV Science 2013 Nov 342 6159 727-30

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria.

Benjamin JL, Sumpter R, Levine B, Hooper LV Cell Host Microbe 2013 Jun 13 6 723-34

A composite bacteriophage alters colonization by an intestinal commensal bacterium.

Duerkop BA, Clements CV, Rollins D, Rodrigues JL, Hooper LV Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 109 43 17621-6

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV Science 2011 Oct 334 6053 255-8

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV Proc. Natl. Acad. Sci. U.S.A. 2008 Dec 105 52 20858-63

Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

Cash HL, Whitham CV, Behrendt CL, Hooper LV Science 2006 Aug 313 5790 1126-30

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y Genes Dev. 2012 Jun 26 12 1306-11

Interactions between the microbiota and the immune system.

Hooper LV, Littman DR, Macpherson AJ Science 2012 Jun 336 6086 1268-73

Epithelial antimicrobial defence of the skin and intestine.

Gallo RL, Hooper LV Nat. Rev. Immunol. 2012 12 7 503-16

• The Academy of Medicine, Engineering, and Science of Texas, Edith and Peter O’Donnell Award in Medicine
  (2013)
• Howard Hughes Medical Institute
  (2008)
• Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
  (2007)
• U.T. Southwestern Endowed Scholar in Biomedical Research
  (2003)
• Burroughs Wellcome Career Award in Biomedical Sciences
  (2000)
• Genzyme Award for Thesis Research in Glycobiology
  (1996)