Joseph Ready, Ph.D. Titles and Appointments Professor Endowed Title Ronald W. Estabrook, Ph.D. Distinguished University Chair in Biomedical Science; Southwestern Medical Foundation Scholar in Biomedical Research School Medical School Department Biochemistry Graduate Programs Organic Chemistry Biography Download Curriculum Vitae I was born in Fayetteville, NC and grew up outside of Philadelphia, PA. As an undergraduate at the University of North Carolina I worked in the laboratories of Paul Kropp and, at the National Institutes of Environmental Health Sciences, Masahiko Negishi. I completed my graduate studies at Harvard University in 2001 under the direction of Eric Jacobsen, studying epoxide ring opening reactions. I then moved to Yale University for a postdoc with John Wood where I focused on total synthesis. I joined the faculty at UT Southwestern in 2003, and my research group currently focuses on natural products synthesis, medicinal chemistry and synthetic methodology. Lab website - http://www.utsouthwestern.edu/labs/ready/ Education Undergraduate University of N C-Chapel Hill (1996), Chemistry Graduate School Harvard University (2001), Chemistry Research Interest Discovery of new chemical reactions; medicinal chemistry; natural products synthesis Publications Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine Hernandez G, Osinski A, Majumdar A, Eitson JL, Antczak M, Pawłowski K, Niederstrasser H, Servage KA, Posner B, Schoggins JW, Ready JM, Tagliabracci VS Journal of Biological Chemistry 2025 Apr 301 Advances in the 1,2-Metalate Rearrangement Chemistry of Alkenylboronates Tran MK, Ready JM Synlett 2025 Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency Tesla R, Guhl C, Werthmann GC, Dixon D, Cenik B, Addepalli Y, Liang J, Fass DM, Rosenthal Z, Haggarty SJ, Williams NS, Posner BA, Ready JM, Herz J Nature communications 2024 Dec 15 Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity Liang J, Wang X, Ortiz F, Shishodia G, Liu T, Gao C, Williams NS, Chuang DT, Wynn RM, Ready JM ACS Medicinal Chemistry Letters 2024 Nov 15 1899-1906 Chemoselective and Stereoselective Allylation of Bis(alkenyl)boronates Tran MK, Ready JM Angewandte Chemie - International Edition 2024 Sep 63 Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA Cell Chemical Biology 2024 Aug 31 1503-1517.e19 Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers Theodoropoulos PC, Guo HH, Wang W, Crossley E, Rivera Cancel G, Fang M, Nguyen T, Baniasadi H, Williams NS, Ready JM, De Brabander JK, Nijhawan D ACS chemical biology 2024 Jun 19 1339-1350 Enzymatic Resolution and Decarboxylative Functionalization of α-Sulfinyl Esters Gahalawat S, Addepalli Y, Fink SP, Kasturi L, Markowitz SD, Ready JM Chemistry - A European Journal 2024 Feb 30 Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4 Peng W, Garcia N, Servage KA, Kohler JJ, Ready JM, Tomchick DR, Fernandez J, Orth K Science Advances 2024 10 Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system Huang W, Li H, Kiselar J, Fink SP, Regmi S, Day A, Yuan Y, Chance M, Ready JM, Markowitz SD, Taylor DJ Nature communications 2023 Dec 14 Results 1-10 of 94 1 2 3 4 5 Next Last Honors & Awards Bonnie Bell Harding Professor of Biochemistry (2018) Alfred P. Sloan Foundation Fellow (2009) Amgen Young Investigator Award (2007) NSF CAREER Award (2006) Southwestern Medical Center Scholar in Biomedical Research (2003) NIH Postdoctoral Fellowship (2001)
