Joseph Ready, Ph.D. Professor Endowed Title Ronald W. Estabrook, Ph.D. Distinguished University Chair in Biomedical Science; Southwestern Medical Foundation Scholar in Biomedical Research School Medical School Department Biochemistry Graduate Programs Organic Chemistry Biography Download Curriculum Vitae I was born in Fayetteville, NC and grew up outside of Philadelphia, PA. As an undergraduate at the University of North Carolina I worked in the laboratories of Paul Kropp and, at the National Institutes of Environmental Health Sciences, Masahiko Negishi. I completed my graduate studies at Harvard University in 2001 under the direction of Eric Jacobsen, studying epoxide ring opening reactions. I then moved to Yale University for a postdoc with John Wood where I focused on total synthesis. I joined the faculty at UT Southwestern in 2003, and my research group currently focuses on natural products synthesis, medicinal chemistry and synthetic methodology. Lab website - http://www.utsouthwestern.edu/labs/ready/ Education Undergraduate University of N C-Chapel Hill (1996), Chemistry Graduate School Harvard University (2001), Chemistry Research Interest Discovery of new chemical reactions; medicinal chemistry; natural products synthesis Publications Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers Theodoropoulos PC, Guo HH, Wang W, Crossley E, Rivera Cancel G, Fang M, Nguyen T, Baniasadi H, Williams NS, Ready JM, De Brabander JK, Nijhawan D ACS chemical biology 2024 Jun 19 1339-1350 Enzymatic Resolution and Decarboxylative Functionalization of α-Sulfinyl Esters Gahalawat S, Addepalli Y, Fink SP, Kasturi L, Markowitz SD, Ready JM Chemistry - A European Journal 2024 Feb 30 Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4 Peng W, Garcia N, Servage KA, Kohler JJ, Ready JM, Tomchick DR, Fernandez J, Orth K Science Advances 2024 10 Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system Huang W, Li H, Kiselar J, Fink SP, Regmi S, Day A, Yuan Y, Chance M, Ready JM, Markowitz SD, Taylor DJ Nature communications 2023 Dec 14 Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJ, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D Cell Chemical Biology 2023 Nov 30 1453-1467.e8 Asymmetric Catalytic Hydroboration of Enol Carbamates Enables an Enantioselective Matteson Homologation Kuznetsov DM, Ready JM Synlett 2023 May 34 2181-2186 Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes McGettigan JE, Ready JM Angewandte Chemie - International Edition 2023 Apr 62 Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL) Imlay LS, Lawong AK, Gahalawat S, Kumar A, Xing C, Mittal N, Wittlin S, Churchyard A, Niederstrasser H, Crespo-Fernandez B, Posner BA, Gamo FJ, Baum J, Winzeler EA, Laleu B, Ready JM, Phillips MA ACS infectious diseases 2023 Mar 9 527-539 Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration Hu B, Toda K, Wang X, Antczak MI, Smith J, Geboers S, Nishikawa G, Li H, Dawson D, Fink S, Desai AB, Williams NS, Markowitz SD, Ready JM Journal of Medicinal Chemistry 2022 Nov 65 15327-15343 Mechanistic Basis for the Iridium-Catalyzed Enantioselective Allylation of Alkenyl Boronates Davis CR, Fu Y, Liu P, Ready JM Journal of the American Chemical Society 2022 Sep 144 16118-16130 Results 1-10 of 88 1 2 3 4 5 Next Last Honors & Awards Bonnie Bell Harding Professor of Biochemistry (2018) Alfred P. Sloan Foundation Fellow (2009) Amgen Young Investigator Award (2007) NSF CAREER Award (2006) Southwestern Medical Center Scholar in Biomedical Research (2003) NIH Postdoctoral Fellowship (2001)
