Biography

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Dr. Karner is originally from Oklahoma. He earned his Ph.D. at UT Southwestern in the laboratory of Dr. Thomas Carroll where he studied WNT signaling in the developing kidney. After this, he received postdoctoral training at Washington University School of Medicine in St Louis, Missouri where he studied the interplay of WNT signaling and cellular metabolism during osteoblast differentiation. He next established his laboratory in the Department of Orthopaedic Surgery at Duke University in Durham, North Carolina. While at Duke, Dr. Karner identified glutamine as a critical nutrient regulating multiple stages of osteoblast differentiation. Dr. Karner is excited to bring his expertise in developmental bone biology, WNT signaling and amino acid metabolism back to UTSW. His laboratory focuses on the role and regulation of amino acid metabolism during cell fate specification and differentiation with a special emphasis on identifying novel bone forming therapies. Outside of the lab, he has limited personal interests outside of cooking and chauffeuring his children to various sporting or school related events.

Research Interest

  • Amino Acid Transport
  • Bone Development and Homeostasis
  • Cellular Differentiation
  • Cellular Metabolism
  • Glutamine Metabolism
  • Osteoblast/Bone Formation
  • Osteoclast/Bone Resorption
  • Osteoporosis
  • Proline Metabolism
  • WNT Signaling

Publications

Featured Publications LegendFeatured Publications

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts.
Shen L, Karner CM, J Vis Exp 2022 04 182
Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with IDH mutations.
Zhang H, Puviindran V, Nadesan P, Ding X, Shen L, Tang YJ, Tsushima H, Yahara Y, Ban GI, Zhang GF, Karner CM, Alman B, J Bone Miner Res 2022 Feb
Hypertrophic chondrocytes serve as a reservoir for marrow associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.
Long JT, Leinroth A, Liao Y, Ren Y, Mirando AJ, Nguyen T, Guo W, Sharma D, Rouse D, Wu C, Cheah KSE, Karner CM, Hilton MJ, Elife 2022 Feb 11
Bioenergetic Metabolism In Osteoblast Differentiation.
Shen L, Hu G, Karner CM, Curr Osteoporos Rep 2022 Feb

Books

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Honors & Awards

  • Joe B. Milam Award
    Distinguished Alumnus - East Central University (2017)
  • John Haddad Young Investigator Award
    Advances in Mineral MEtabolism (AIMM) and American Society of Bone and Mineral Research (ASBMR) (2017)
  • Harold M. Frost Young Investigator Award
    American Society of Bone and Mineral Research (2016)
  • Nominata Award
    Best Graduate Thesis - UT Southwestern Medical Center (2010)
  • Academic All-American
    College Sports Information Directors of America (CoSIDA) (2003)

Professional Associations/Affiliations

  • Advances in Mineral Metabolism (2017)
  • Orthopaedic Research Society (ORS) (2016)
  • American Society for Bone and Mineral Research (ASBMR) (2012)
  • Society for Developmental BIology (SDB) (2010)