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Courtney Karner, Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Nephrology in the Pak Center for Mineral Metabolism and Clinical Research.

Originally from Lincoln, Nebraska, Dr. Karner holds a bachelor's degree in biology from East Central University in Ada, Oklahoma. He completed his postdoctorate degree in genetics and developmental biology from UT Southwestern. He later completed a postdoctoral fellowship in orthopedic research and cell biology at Washington University School of Medicine in St. Louis.

Dr. Karner joined the UT Southwestern faculty in 2020. 

At UT Southwestern, Dr. Karner is on the Propel Mentorship Program Mentoring Committee.

Dr. Karner's lab at UT Southwestern focuses on deciphering the role and regulation of cellular metabolism during cell fate specification and differentiation in the context of bone development and disease.

Dr. Karner is a member of the Society for Developmental Biology, the American Society for Bone and Mineral Research, the Orthopaedic Research Society, and Advances in Mineral Metabolism.

Research Interest

  • Amino Acid Transport
  • Bone Development and Homeostasis
  • Cellular Differentiation
  • Cellular Metabolism
  • Glutamine Metabolism
  • Osteoblast/Bone Formation
  • Osteoclast/Bone Resorption
  • Osteoporosis
  • Proline Metabolism
  • WNT Signaling


Featured Publications LegendFeatured Publications

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts.
Shen L, Karner CM, J Vis Exp 2022 04 182
Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with IDH mutations.
Zhang H, Puviindran V, Nadesan P, Ding X, Shen L, Tang YJ, Tsushima H, Yahara Y, Ban GI, Zhang GF, Karner CM, Alman B, J Bone Miner Res 2022 Feb
Hypertrophic chondrocytes serve as a reservoir for marrow associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.
Long JT, Leinroth A, Liao Y, Ren Y, Mirando AJ, Nguyen T, Guo W, Sharma D, Rouse D, Wu C, Cheah KSE, Karner CM, Hilton MJ, Elife 2022 Feb 11


Featured Books Legend Featured Books

Honors & Awards

  • Joe B. Milam Award
    Distinguished Alumnus - East Central University (2017)
  • John Haddad Young Investigator Award
    Advances in Mineral MEtabolism (AIMM) and American Society of Bone and Mineral Research (ASBMR) (2017)
  • Harold M. Frost Young Investigator Award
    American Society of Bone and Mineral Research (2016)
  • Nominata Award
    Best Graduate Thesis - UT Southwestern Medical Center (2010)
  • Academic All-American
    College Sports Information Directors of America (CoSIDA) (2003)

Professional Associations/Affiliations

  • Advances in Mineral Metabolism (2017)
  • American Society for Bone and Mineral Research (ASBMR) (2012)
  • Orthopaedic Research Society (ORS) (2016)
  • Society for Developmental BIology (SDB) (2010)