
Jin-Sung Chung, Ph.D.
Instructor
School Medical School
Department Dermatology
Education
- Undergraduate
- Unlisted - International Colle (1993), Biochemistry
- Graduate School
- Unlisted - International Colle (1996), Biochemistry
- Graduate School
- University of Tokyo (2003), Agriculture
Research Interest
- Atophic dermatitis
- Langerhans and dendritic cells
Publications
Featured Publications
- Sezary Syndrome Cells Overexpress Syndecan-4 Bearing Distinct Heparan Sulfate Moieties that Suppress T cell Activation by Binding DC-HIL and Trapping TGF-beta on the Cell Surface.
- Chung, JS, L.H. Shiue, M. Duvic, A. Pandya, Ponciano D. Cruz, Jr, and K. Ariizumi Blood 2011 117 3382-3390
- DC-HIL is a negative regulator of T lymphocyte activation.
- Chung, JS, Kota S, Dougherty I, Cruz PD, Ariizumi K Blood May 2007 109 4320-4327
- Inhibition of T-cell Activation by Syndecan-4 Is Mediated by CD148 Through Protein Tyrosine Phosphatase Activity.
- Chung, JS., Ponciano D. Cruz Jr, and K. Ariizumi Eup. J. Immunol. 2011 41 1794-1799
- DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.
- *Tomihari M., *JS. Chung, H. Akioshi, Ponciano D. Cruz Jr., and K. Ariizumi * equal contribution Cancer Res. 2010 70 5778-5787
- Depleting syndecan-4+ T lymphocytes using toxin-bearing DC-HIL: A new opportunity for treating activated T cell-driven disease.
- *Akiyoshi H., *JS. Chung, M. Tomihari, Ponciano D. Cruz Jr., and K. Ariizumi * equal contribution. J. Immunol. 2010 184 3554-3561
- The DC-HIL/syndecan-4 pathway inhibits human allogeneic T cell response.
- Chung, JS, M. Bonkobra, M. Tomihari, Ponciano D. Cruz Jr., and K. Ariizumi Eup. J. Immunol. 2009 39 965-974
- Binding of dermatophytic fungi induces tyrosine phoshorylation and potentiates antigen presenting cell function.
- Chung, JS, T. Yudate, M. Tomihari, H. Akiyoshi, Ponciano D. Cruz Jr., and K. Ariizumi J. Immunol. 2009 183 5190-5198
- Gpnmb is a melanosome-associated glycoprotein that contributes to melanocytes/keratinocyte adhesion in a RGD-dependent fashion.
- Tomihari, M., SH. Hwang, JS. Chung, Ponciano D. Cruz Jr., and K. Ariizumi Exp. Dermatol. 2009 18 586-595
- Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation.
- Chung JS, Dougherty I, Cruz PD, and K. Ariizumi J. Immunol. 2007 179 5778-5784
- Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor chain to induce innate immune responses.
- Kota, S., XI. Yang, T. Yudate, JS. Chung, J. Wu, K. Luby-Phelps, R. P. Kimberly, D. Underhill, P. D. Cruz, Jr., and K. Ariizumi J. Biol. Chem. 2006 281 38854-38866
Honors & Awards
- Albert M. Kligman Fellowship
Society for Investigative Dermatology (2005) - Fellowship
Japan Society for Bioscience, Biotechnology, and Agrochemistry (2002)
Professional Associations/Affiliations
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Society for Investigative Dermatology