Jin-Sung Chung, Ph.D.

• Atophic dermatitis
• Langerhans and dendritic cells

 Featured Publications

Sezary Syndrome Cells Overexpress Syndecan-4 Bearing Distinct Heparan Sulfate Moieties that Suppress T cell Activation by Binding DC-HIL and Trapping TGF-beta on the Cell Surface.

Chung, JS, L.H. Shiue, M. Duvic, A. Pandya, Ponciano D. Cruz, Jr, and K. Ariizumi Blood 2011 117 3382-3390

DC-HIL is a negative regulator of T lymphocyte activation.

Chung, JS, Kota S, Dougherty I, Cruz PD, Ariizumi K Blood May 2007 109 4320-4327

Inhibition of T-cell Activation by Syndecan-4 Is Mediated by CD148 Through Protein Tyrosine Phosphatase Activity.

Chung, JS., Ponciano D. Cruz Jr, and K. Ariizumi Eup. J. Immunol. 2011 41 1794-1799

DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells.

*Tomihari M., *JS. Chung, H. Akioshi, Ponciano D. Cruz Jr., and K. Ariizumi * equal contribution Cancer Res. 2010 70 5778-5787

Depleting syndecan-4+ T lymphocytes using toxin-bearing DC-HIL: A new opportunity for treating activated T cell-driven disease.

*Akiyoshi H., *JS. Chung, M. Tomihari, Ponciano D. Cruz Jr., and K. Ariizumi * equal contribution. J. Immunol. 2010 184 3554-3561

The DC-HIL/syndecan-4 pathway inhibits human allogeneic T cell response.

Chung, JS, M. Bonkobra, M. Tomihari, Ponciano D. Cruz Jr., and K. Ariizumi Eup. J. Immunol. 2009 39 965-974

Binding of dermatophytic fungi induces tyrosine phoshorylation and potentiates antigen presenting cell function.

Chung, JS, T. Yudate, M. Tomihari, H. Akiyoshi, Ponciano D. Cruz Jr., and K. Ariizumi J. Immunol. 2009 183 5190-5198

Gpnmb is a melanosome-associated glycoprotein that contributes to melanocytes/keratinocyte adhesion in a RGD-dependent fashion.

Tomihari, M., SH. Hwang, JS. Chung, Ponciano D. Cruz Jr., and K. Ariizumi Exp. Dermatol. 2009 18 586-595

Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation.

Chung JS, Dougherty I, Cruz PD, and K. Ariizumi J. Immunol. 2007 179 5778-5784

Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor  chain to induce innate immune responses.

Kota, S., XI. Yang, T. Yudate, JS. Chung, J. Wu, K. Luby-Phelps, R. P. Kimberly, D. Underhill, P. D. Cruz, Jr., and K. Ariizumi J. Biol. Chem. 2006 281 38854-38866

• Albert M. Kligman Fellowship
  Society for Investigative Dermatology (2005)
• Fellowship
  Japan Society for Bioscience, Biotechnology, and Agrochemistry (2002)

• Japan Society for Bioscience, Biotechnology, and Agrochemistry
• Society for Investigative Dermatology