Joachim Seemann, Ph.D. Associate Professor Endowed Title Virginia Murchison Linthicum Scholar in Medical Research School Medical School Department Cell Biology Graduate Programs Cancer Biology, Cell and Molecular Biology Biography UT Southwestern Medical Center, Department of Cell Biology Associate Professor (2011-present) UT Southwestern Medical Center, Department of Cell Biology Assistant Professor (2003-2011) Yale School of Medicine, New Haven, CT Postdoctoral Fellow (2000-2003) Cancer Research UK London Research Institute, United Kingdom Postdoctoral Fellow (1997-1999) Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany Graduate Student, PhD (1993-1996) University of Stuttgart, Germany Diploma in Biology (1993) Education Graduate School Max Planck Inst for Biophysica (1996), Biophysical Chemistry Research Interest Golgi and organelle biogenesis Membrane traffic Migration of cells Mitosis Publications Featured Publications RNA scaffolds the Golgi ribbon by forming condensates with GM130. Zhang Y, Seemann J, Nat Cell Biol 2024 Jul 26 7 1139-1153 Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure. Zhang Y, Seemann J, J Cell Biol 2021 Jan 220 1 Mitotic Golgi disassembly is required for bipolar spindle formation and mitotic progression. Guizzunti G, Seemann J Proc. Natl. Acad. Sci. U.S.A. 2016 Oct 113 43 E6590-E6599 GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Wei JH, Zhang ZC, Wynn RM, Seemann J Cell 2015 Jul 162 2 287-99 An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis. Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, Ye Y, Seemann J, Levine B, Tang Z, Zhong Q, Nat Commun 2023 Mar 14 1 1687 Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol. Trinh MN, Brown MS, Seemann J, Vale G, McDonald JG, Goldstein JL, Lu F, Proc Natl Acad Sci U S A 2022 Jan 119 2 Importin a phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation. Guo H, Wei JH, Zhang Y, Seemann J, J Cell Sci 2021 Feb 134 4 Point Mutation in Luminal Loop 7 of Scap Blocks Interaction with Loop 1 and Abolishes Movement to Golgi. Zhang Y, Motamed M, Seemann J, Brown MS, Goldstein JL J. Biol. Chem. 2013 Apr Modular organization of the mammalian Golgi apparatus. Nakamura N, Wei JH, Seemann J Curr. Opin. Cell Biol. 2012 Aug 24 4 467-74 Golgi Biogenesis. Wang Y, Seemann J Cold Spring Harbor perspectives in biology 2011 Jun Results 1-10 of 20 1 2 Next Last Honors & Awards Virginia Murchison Lithicum Scholar in Medical ResearchUT Southwestern Endowed Scholar (2003) Imperial Cancer Research FundPostdoctoral Fellowship (1999) German Research FoundationPostdoctoral Fellowship (1997) Max Planck SocietyGraduate Fellowship (1994)
