Olaf Stuve, M.D., Ph.D.

Dr. Olaf Stuve is a tenured Professor in the Department of Neurology at UT Southwestern Medical Center, Head of the MS/ Neuroimmunology section, and Chief of Neurology at the VA North Texas Health Care System/ Dallas VA Medical Center.  In addition to his clinical activities, he has been the Principal Investigator and site Principal Investigator for numerous clinical trials.  Dr. Stuve also runs a research laboratory at UT Southwestern, which is studying the differential molecular requirements for bone-marrow-derived leukocytes to cross the blood-brain barrier or other biological barriers that provide immune privilege for the central nervous system (CNS).  He is also exploring molecular and cellular differences between bone-marrow-derived myeloid cells subsets and CNS-intrinsic microglia, and the potential pathogenic role of innate immune cells in early and late MS.  Furthermore, Dr. Stuve's research interests include molecular and cellular markers of autoimmunity, and experimental therapies for autoimmune disorders, and he has numerous ongoing collaborations with national and international investigators.

Dr. Stuve’s research has been supported by grants from the Department of Veterans Affairs, the National Multiple Sclerosis Society (NMSS), the Deutsche Forschungsgemeinschaft (DFG), and Boehringer Ingelheim Fonds.  He has published over 300 research articles, review articles, editorials, and book chapters, and he has given over 200 invited presentations.  Dr. Stuve is a fellow of the American Neurological Association (FANA), the American Academy of Neurology (FAAN), and the European Academy of Neurology (FEAN).  Dr. Stuve has served on numerous editorial boards of medical and scientific journals, and he has been a member of National Institutes of Health (NIH), and National Multiple Sclerosis Society (NMSS) study sections.  Dr. Stuve is a past associate editor of JAMA Neurology, and a past steering committee member of the Immune Tolerance Network (ITN).

Dr. Stuve received his medical degree from the Free University of Berlin, completed a medical doctoral thesis in physiology at the Max Delbruck Center for Molecular Medicine in Berlin magna cum laude, and earned a Ph.D. in immunology in the Department of Clinical and Experimental Immunology at Maastricht University.  He completed a transitional internship at the University of Cape Town, and a preliminary internship and neurology residency at the University of Washington in Seattle.  Dr. Stuve also received postdoctoral fellowship training in neuroimmunology at McGill University in Montreal, and at the University of California, San Francisco (UCSF).

Dr. Stuve has received numerous clinical teaching awards.  He is an elected member of the Alpha Omega Alpha (AOA) Honor Medical Society, and he is a recipient of a Clinical Scientist Development Award from the Doris Duke Charitable Foundation and a Grant for Multiple Sclerosis Innovation (GMSI) from Merck KGaA.  Dr. Stuve has mentored undergraduate students, graduate students, medical students, residents, post-doctoral fellows, and faculty.  Dr. Stuve was elected Top Provider in Neurology at the VA North Texas Health Care System repeatedly by physician peers across medical and surgical specialties, and he has been listed in D Magazine's Best Doctors list.

Medical School

Freie University of Berlin (1993)

Internship

Groote Schuur Hospital, South Africa (1994), Surgery

Fellowship

McGill University Faculty of Medicine (1996), Neuroimmunology

Internship

University of Washington Medical Center (1997), Internal Medicine

Residency

University of Washington Medical Center (2000), Neurology

Fellowship

University of California San Francisco School of Medicine (2003), Neuroimmunology

Other Post Graduate Training

Masstricht University (2006)

Graduate School

Masstricht University (2006), Immunology

• Experimental therapies for autoimmune disorders
• Immune tolerance
• Molecular and cellular markers of autoimmunity

Featured Publications

Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity.

Manouchehri N, Salinas VH, Hussain RZ, Stüve O, Proc Natl Acad Sci U S A 2023 Feb 120 6 e2212696120

CD11c⁺CD88⁺CD317⁺ myeloid cells are critical mediators of persistent CNS autoimmunity.

Manouchehri N, Hussain RZ, Cravens PD, Esaulova E, Artyomov MN, Edelson BT, Wu GF, Cross AH, Doelger R, Loof N, Eagar TN, Forsthuber TG, Calvier L, Herz J, Stüve O, Proc Natl Acad Sci U S A 2021 Apr 118 14

Effects of cladribine tablets on lymphocyte subsets in patients with multiple sclerosis: an extended analysis of surface markers.

Stuve O, Soelberg Soerensen P, Leist T, Giovannoni G, Hyvert Y, Damian D, Dangond F, Boschert U, Ther Adv Neurol Disord 2019 12 1756286419854986

MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis.

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stüve O, Front Immunol 2019 10 903

The antioxidant MnTBAP does not effectively downregulate CD4 expression in T cells in vivo.

Manouchehri N, Guisso DR, Hussain RZ, Minassian BA, Stüve O, J Neuroimmunol 2021 Mar 354 577544

a4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model.

Hussain RZ, Cravens PD, Miller-Little WA, Doelger R, Granados V, Herndon E, Okuda DT, Eagar TN, Stüve O, Neurol Neuroimmunol Neuroinflamm 2019 Jul 6 4 e563

Defining standard enzymatic dissociation methods for individual brains and spinal cords in EAE.

Hussain RZ, Miller-Little WA, Doelger R, Cutter GR, Loof N, Cravens PD, Stüve O Neurol Neuroimmunol Neuroinflamm 2018 Mar 5 2 e437

TLR3 Agonism Re-Establishes CNS Immune Competence During a 4-integrin Deficiency

Hussain RZ, Cravens PC, Doelger R, Dentel B, Herndon E, Loof N, Tsai P, Okuda DT, Racke MK, Stüve O. Ann Clin Transl Neurol 2018 12 5 1543-1561

• D Magazine's Best Doctors list
  Neurology (2019)
• D Magazine's Best Doctors list
  Neurology (2018)
• Visiting Professorship
  University Erlangen, Germany (2017)
• Alpha Omega Alpha (ΑΩΑ) Honor Medical Society
  Honorary member, Texas Gamma Chapter (2013)
• Clinical Teaching Award Neurology
  University of Texas Southwestern Medical School, Class of 2012 (2011)
• Clinical Teaching Award Neurology
  University of Texas Southwestern Medical School, Class of 2011 (2010)
• Clinical Scientist Development Award
  Doris Duke Charitable Foundation (2009)
• Clinical Teaching Award Neurology
  University of Texas Southwestern Medical School, Class of 2008 (2007)
• Postdoctoral scholarship
  Boehringer Ingelheim Fonds (2001)
• Advanced postdoctoral fellowship grant
  National Multiple Sclerosis Society (NMSS) (2000)
• H.-L. Teuber price
  The Montreal Neurological Institute, McGill University, Montreal (1996)
• Postdoctoral fellowship grant
  Deutsche Forschungsgemeinschaft (DFG), Germany (1995)
• Magna cum laude M.D. thesis
  Free University of Berlin, Germany (1994)

• Department of Neurology, UT Southwestern (2005)
• Neurology Section, VA North Texas Health Care System (2005)