Olaf Stuve, M.D., Ph.D. Chief of Neurology, Dallas Veterans Affairs Medical Center Professor School Medical School Department Neurology Graduate Programs Immunology Biography Dr. Olaf Stuve is a Professor in the Department of Neurology at UT Southwestern Medical Center, Head of the MS/ Neuroimmunology section, and Chief of Neurology at the VA North Texas Health Care System/ Dallas VA Medical Center. Dr. Stuve joined UT Southwestern in 2005. At the Dallas VA Medical Center, he attends to US veterans with multiple sclerosis (MS) and other neurological disorders. In addition to his clinical activities, Dr. Stuve has been the Principal Investigator and site Principal Investigator for numerous clinical trials. Dr. Stuve also runs a research laboratory at UT Southwestern, which is studying the differential molecular requirements for bone-marrow-derived leukocytes to cross the blood-brain barrier or other biological barriers that provide immune privilege for the central nervous system (CNS). He is also exploring molecular and cellular differences between bone-marrow-derived myeloid cell subsets and CNS-intrinsic microglia, and the potential pathogenic role of innate immune cells in early and late MS. Furthermore, Dr. Stuve's research interests include molecular and cellular markers of autoimmunity, and experimental therapies for autoimmune disorders, and he has numerous ongoing collaborations with national and international investigators. Dr. Stuve received his medical degree from the Free University of Berlin, completed a medical doctoral thesis in physiology at the Max Delbruck Center for Molecular Medicine in Berlin magna cum laude, and earned a Ph.D. in immunology in the Department of Clinical and Experimental Immunology at Maastricht University. He completed a transitional internship at the University of Cape Town, and a preliminary internship and neurology residency at the University of Washington in Seattle. Dr. Stuve also received postdoctoral fellowship training in neuroimmunology at McGill University in Montreal, and at the University of California, San Francisco (UCSF). Dr. Stuve’s research has been supported by grants from the Department of Veterans Affairs (VA), the National Multiple Sclerosis Society (NMSS), the Deutsche Forschungsgemeinschaft (DFG), and Boehringer Ingelheim Fonds. He has published over 300 research articles, review articles, editorials, and book chapters, and he has given over 200 invited presentations. Dr. Stuve is a fellow of the American Neurological Association (FANA), the American Academy of Neurology (FAAN), and the European Academy of Neurology (FEAN). Dr. Stuve has served on numerous editorial boards of medical and scientific journals, and he has been a member of National Institutes of Health (NIH), NMSS, and VA study sections. Dr. Stuve is a past associate editor of JAMA Neurology, and a past steering committee member of the Immune Tolerance Network (ITN). Dr. Stuve has received numerous clinical teaching awards. He is an elected member of the Alpha Omega Alpha (AOA) Honor Medical Society, and he is a recipient of a Clinical Scientist Development Award from the Doris Duke Charitable Foundation and a Grant for Multiple Sclerosis Innovation (GMSI) from Merck KGaA. Dr. Stuve has mentored undergraduate students, graduate students, medical students, residents, post-doctoral fellows, and faculty. Dr. Stuve was elected Top Provider in Neurology at the VA North Texas Health Care System repeatedly by physician peers across medical and surgical specialties, and he has been listed in D Magazine's Best Doctors list. Education Medical School Freie University Berlin (1993), Medicine Medical School Max Delbruck Center for Molecu (1994), Physiology Graduate School Maastricht University (1994), Immunology Research Interest Experimental therapies for autoimmune disorders Immune tolerance Molecular and cellular markers of autoimmunity Publications Featured Publications Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity. Manouchehri N, Salinas VH, Hussain RZ, Stüve O, Proc Natl Acad Sci U S A 2023 Feb 120 6 e2212696120 CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. Manouchehri N, Hussain RZ, Cravens PD, Esaulova E, Artyomov MN, Edelson BT, Wu GF, Cross AH, Doelger R, Loof N, Eagar TN, Forsthuber TG, Calvier L, Herz J, Stüve O, Proc Natl Acad Sci U S A 2021 Apr 118 14 Effects of cladribine tablets on lymphocyte subsets in patients with multiple sclerosis: an extended analysis of surface markers. Stuve O, Soelberg Soerensen P, Leist T, Giovannoni G, Hyvert Y, Damian D, Dangond F, Boschert U, Ther Adv Neurol Disord 2019 12 1756286419854986 MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stüve O, Front Immunol 2019 10 903 The antioxidant MnTBAP does not effectively downregulate CD4 expression in T cells in vivo. Manouchehri N, Guisso DR, Hussain RZ, Minassian BA, Stüve O, J Neuroimmunol 2021 Mar 354 577544 a4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model. Hussain RZ, Cravens PD, Miller-Little WA, Doelger R, Granados V, Herndon E, Okuda DT, Eagar TN, Stüve O, Neurol Neuroimmunol Neuroinflamm 2019 Jul 6 4 e563 Defining standard enzymatic dissociation methods for individual brains and spinal cords in EAE. Hussain RZ, Miller-Little WA, Doelger R, Cutter GR, Loof N, Cravens PD, Stüve O Neurol Neuroimmunol Neuroinflamm 2018 Mar 5 2 e437 TLR3 Agonism Re-Establishes CNS Immune Competence During a 4-integrin Deficiency Hussain RZ, Cravens PC, Doelger R, Dentel B, Herndon E, Loof N, Tsai P, Okuda DT, Racke MK, Stüve O. Ann Clin Transl Neurol 2018 12 5 1543-1561 Results 1-8 of 8 1 Honors & Awards D Magazine's Best Doctors listNeurology (2019) D Magazine's Best Doctors listNeurology (2018) Visiting ProfessorshipUniversity Erlangen, Germany (2017) Alpha Omega Alpha (ΑΩΑ) Honor Medical SocietyHonorary member, Texas Gamma Chapter (2013) Clinical Teaching Award NeurologyUniversity of Texas Southwestern Medical School, Class of 2012 (2011) Clinical Teaching Award NeurologyUniversity of Texas Southwestern Medical School, Class of 2011 (2010) Clinical Scientist Development AwardDoris Duke Charitable Foundation (2009) Clinical Teaching Award NeurologyUniversity of Texas Southwestern Medical School, Class of 2008 (2007) Postdoctoral scholarshipBoehringer Ingelheim Fonds (2001) Advanced postdoctoral fellowship grantNational Multiple Sclerosis Society (NMSS) (2000) H.-L. Teuber priceThe Montreal Neurological Institute, McGill University, Montreal (1996) Postdoctoral fellowship grantDeutsche Forschungsgemeinschaft (DFG), Germany (1995) Magna cum laude M.D. thesisFree University of Berlin, Germany (1994) Professional Associations/Affiliations Department of Neurology, UT Southwestern (2005) Neurology Section, VA North Texas Health Care System (2005)
