Univ of California-Berkeley (1997), Molecular & Cell Biology
Univ of California-Berkeley (1997), Bioengineering
Graduate School
Stanford University (2002), Biophysics

Research Interest

  • How cells control their cholesterol levels


Featured Publications LegendFeatured Publications

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum.
Johnson KA, Endapally S, Vazquez DC, Infante RE, Radhakrishnan A, J. Biol. Chem. 2019 Oct
Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R, Elife 2019 Oct 8
Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
Endapally S, Frias D, Grzemska M, Gay A, Tomchick DR, Radhakrishnan A Cell 2019 Jan
Monitoring and Modulating Intracellular Cholesterol Trafficking Using ALOD4, a Cholesterol-Binding Protein.
Endapally S, Infante RE, Radhakrishnan A Methods Mol. Biol. 2019 1949 153-163
Retrospective on Cholesterol Homeostasis: The Central Role of Scap
Brown MS, Radhakrishnan A, Goldstein JL Annu Rev Biochem. 2018 Jun 87 783-807
Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.
Infante RE, Radhakrishnan A Elife 2017 Apr 6
Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis.
Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A J. Biol. Chem. 2017 Apr
Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin.
Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH Elife 2017 Feb 6
Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.
Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A J. Biol. Chem. 2016 Apr
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan SF, Radhakrishnan A, Yan N Science 2015 Jul 349 6244 187-91