Education

Undergraduate
Univ of California-Berkeley (1997), Molecular & Cell Biology
Undergraduate
Univ of California-Berkeley (1997), Bioengineering
Graduate School
Stanford University (2002), Biophysics

Research Interest

  • How cells control their cholesterol levels

Publications

Featured Publications LegendFeatured Publications

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM, Cell 2021 Jun
The use of anthrolysin O and ostreolysin A to study cholesterol in cell membranes.
Johnson KA, Radhakrishnan A, Methods Enzymol 2021 649 543-566
Cholesterol access in cellular membranes controls Hedgehog signaling.
Radhakrishnan A, Rohatgi R, Siebold C, Nat Chem Biol 2020 Dec 16 12 1303-1313
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis.
Kober DL, Xu S, Li S, Bajaj B, Liang G, Rosenbaum DM, Radhakrishnan A, Proc Natl Acad Sci U S A 2020 Oct
Accessible cholesterol is localized in bacterial plasma membrane protrusions.
Abrams ME, Johnson KA, Radhakrishnan A, Alto NM, J. Lipid Res. 2020 Jul
Accessibility of cholesterol at cell surfaces.
Johnson KA, Radhakrishnan A, J. Lipid Res. 2020 Apr
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Abrams ME, Johnson KA, Perelman SS, Zhang LS, Endapally S, Mar KB, Thompson BM, McDonald JG, Schoggins JW, Radhakrishnan A, Alto NM, Nat Microbiol 2020 Apr
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I, Cell Metab. 2020 Apr
Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum.
Johnson KA, Endapally S, Vazquez DC, Infante RE, Radhakrishnan A, J. Biol. Chem. 2019 Oct
Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R, Elife 2019 Oct 8