Arun Radhakrishnan, Ph.D.
Associate Professor

Undergraduate

Univ of California-Berkeley (1997), Molecular & Cell Biology

Undergraduate

Univ of California-Berkeley (1997), Bioengineering

Graduate School

Stanford University (2002), Biophysics

• How cells control their cholesterol levels

Featured Publications

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum.

Johnson KA, Endapally S, Vazquez DC, Infante RE, Radhakrishnan A, J. Biol. Chem. 2019 Oct

Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling.

Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R, Elife 2019 Oct 8

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.

Endapally S, Frias D, Grzemska M, Gay A, Tomchick DR, Radhakrishnan A Cell 2019 Jan

Monitoring and Modulating Intracellular Cholesterol Trafficking Using ALOD4, a Cholesterol-Binding Protein.

Endapally S, Infante RE, Radhakrishnan A Methods Mol. Biol. 2019 1949 153-163

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Brown MS, Radhakrishnan A, Goldstein JL Annu Rev Biochem. 2018 Jun 87 783-807

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.

Infante RE, Radhakrishnan A Elife 2017 Apr 6

Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis.

Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A J. Biol. Chem. 2017 Apr

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin.

Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH Elife 2017 Feb 6

Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.

Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A J. Biol. Chem. 2016 Apr

PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.

Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan SF, Radhakrishnan A, Yan N Science 2015 Jul 349 6244 187-91