- How proteins sense cholesterol in cell membranes
- Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
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- Retrospective on Cholesterol Homeostasis: The Central Role of Scap
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- Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.
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- Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis.
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- Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin.
- Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH Elife 2017 Feb 6
- Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.
- Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A J. Biol. Chem. 2016 Apr
- PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
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- Switch-like Responses of Two Cholesterol Sensors Do Not Require Protein Oligomerization in Membranes.
- Gay A, Rye D, Radhakrishnan A Biophys. J. 2015 Mar 108 6 1459-69
- Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis.
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- Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells.
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