Download Curriculum Vitae

Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.

Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.

Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG).


Medical School
University of California at San Francisco (1997)
University of California at San Francisco (1998), Pediatrics
University of California at San Francisco (2000), Pediatrics
UT Southwestern Medical Center (2005), Pediatric Critical Care Medicine

Research Interest

  • MRI imaging biomarkers of neuronal injury
  • Neural stem cells
  • Traumatic brain injury


Featured Publications LegendFeatured Publications

Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness.
Cohn EC, Robertson TS, Scott SA, Finley AM, Huang R, Miles DK Neurocrit Care 2017 Jul
Abusive Head Trauma and Mortality-An Analysis From an International Comparative Effectiveness Study of Children With Severe Traumatic Brain Injury.
Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM Crit. Care Med. 2017 Apr
Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC, Clark AE, Dean JM N. Engl. J. Med. 2017 01 376 4 318-329
Regional cerebral abnormalities measured by frequency-domain near-infrared spectroscopy in pediatric patients during extracorporeal membrane oxygenation.
Tian F, Jenks C, Potter D, Miles D, Raman L ASAIO J. 2016 Dec
Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study.
Kurz JE, Poloyac SM, Abend NS, Fabio A, Bell MJ, Wainwright MS Pediatr Crit Care Med 2016 Jul 17 7 649-57
Predicting Outcome After Pediatric Head Injury by Early Magnetic Resonance Imaging Lesion Location and Volume.
Miles DK, Smitherman E, Hernandez A, Stavinoha PL, Huang R, Kernie S, Diaz-Arrastia R J. Neurotrauma 2015 Mar
Differences in medical therapy goals for children with severe traumatic brain injury-an international study.
Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR Pediatr Crit Care Med 2013 Oct 14 8 811-8
The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury.
Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR J. Neurosci. 2008 Oct 28 43 10983-9


Featured Books Legend Featured Books

Honors & Awards

  • Conferred Thesis Dissertation
    Presented by the University of California San Francisco (1996)
  • Dean’s Prize for Research
    Presented by the University of California San Francisco (1996)
  • Western Society of Pediatric Research Lowell Glasgow Award
    Presented by the University of California San Francisco (1995)
  • Magna cum Laude
    San Jose State University (1993)
  • Minority Access to Research Careers Fellowship
    San Jose State University (1993)

Professional Associations/Affiliations

  • Pediatric Neurocritical Care Research Group (2009)
  • Perot Center for Brain and Nerve Injury (2008-2014)
  • National Neurotrauma Society
  • Society of Critical Care Medicine
  • Society of Neuroscience