Darryl Miles, M.D.

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Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.

Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.

Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG).

Medical School

University of California at San Francisco (1997)

Internship

University of California at San Francisco (1998), Pediatrics

Residency

University of California at San Francisco (2000), Pediatrics

Fellowship

UT Southwestern Medical Center (2005), Pediatric Critical Care Medicine

• Cerebral autoregulation
• Neuroimaging biomarkers
• Pediatric neurocritical care
• Quality improvement in pediatric neurocritical care
• Traumatic brain injury

Featured Publications

Use of magnetic resonance imaging in severe pediatric traumatic brain injury: assessment of current practice.

Ferrazzano PA, Rosario BL, Wisniewski SR, Shafi NI, Siefkes HM, Miles DK, Alexander AL, Bell MJ J Neurosurg Pediatr 2019 Feb 1-9

Age and Mortality in Pediatric Severe Traumatic Brain Injury: Results from an International Study.

Sarnaik A, Ferguson NM, O'Meara AMI, Agrawal S, Deep A, Buttram S, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Vavilala MS Neurocrit Care 2018 Jun 28 3 302-313

Assessment of Recovery Following Pediatric Traumatic Brain Injury.

Slovis JC, Gupta N, Li NY, Kernie SG, Miles DK Pediatr Crit Care Med 2018 Feb

Extubation Failure and Tracheostomy Placement in Children with Acute Neurocritical Illness.

Cohn EC, Robertson TS, Scott SA, Finley AM, Huang R, Miles DK Neurocrit Care 2017 Jul

Abusive Head Trauma and Mortality-An Analysis From an International Comparative Effectiveness Study of Children With Severe Traumatic Brain Injury.

Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM Crit. Care Med. 2017 Apr

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.

Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC, Clark AE, Dean JM N. Engl. J. Med. 2017 01 376 4 318-329

Regional cerebral abnormalities measured by frequency-domain near-infrared spectroscopy in pediatric patients during extracorporeal membrane oxygenation.

Tian F, Jenks C, Potter D, Miles D, Raman L ASAIO J. 2016 Dec

Variation in Anticonvulsant Selection and Electroencephalographic Monitoring Following Severe Traumatic Brain Injury in Children-Understanding Resource Availability in Sites Participating in a Comparative Effectiveness Study.

Kurz JE, Poloyac SM, Abend NS, Fabio A, Bell MJ, Wainwright MS Pediatr Crit Care Med 2016 Jul 17 7 649-57

Predicting Outcome After Pediatric Head Injury by Early Magnetic Resonance Imaging Lesion Location and Volume.

Miles DK, Smitherman E, Hernandez A, Stavinoha PL, Huang R, Kernie S, Diaz-Arrastia R J. Neurotrauma 2015 Mar

Differences in medical therapy goals for children with severe traumatic brain injury-an international study.

Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR Pediatr Crit Care Med 2013 Oct 14 8 811-8

 Featured Books

Pediatric Neurocritical Care. In Agrawal A, Britz G, eds. Pediatric Vascular Neurosurgery.

Cruz-Navarro J, Miles DK, McDonagh DL. (2016). Springer International Publishing; 57-76.

• Conferred Thesis Dissertation
  Presented by the University of California San Francisco (1996)
• Dean’s Prize for Research
  Presented by the University of California San Francisco (1996)
• Western Society of Pediatric Research Lowell Glasgow Award
  Presented by the University of California San Francisco (1995)
• Magna cum Laude
  San Jose State University (1993)
• Minority Access to Research Careers Fellowship
  San Jose State University (1993)

• American Institute for Ultrasound Medicine
• Pediatric Neurocritical Care Research Group (2009)