Kenneth Chen, M.D. Titles and Appointments Assistant Professor Schools Medical School | Graduate School Departments Pediatrics | Children's Medical Center Research Institute at UT Southwestern Graduate Programs Cancer Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Kenneth S. Chen, M.D., is an Assistant Professor of Pediatrics and the Children's Medical Center Research Institute. He is an Attending Physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas. Dr. Chen received his B.S.E. in biomedical engineering from Johns Hopkins University and M.D. from UT Southwestern. He then completed pediatric residency and pediatric hematology-oncology fellowship at UT Southwestern, where he joined the laboratory of James F. Amatruda. As a physician-scientist, he divides his time between his research laboratory and Children’s Medical Center in Dallas, where he specializes in the care of children with cancer and blood disorders. His research interests in the laboratory focus on understanding the genetic drivers of childhood cancers, especially Wilms tumor, pleuropulmonary blastoma, and other cancers driven by mutations that impair microRNA processing. Education Medical School UT Southwestern Medical School (2006) Internship UT Southwestern/Children's Medical Center (2007), Pediatrics Residency UT Southwestern/Children's Medical Center (2009), Pediatrics Fellowship UT Southwestern/Children's Medical Center (2013), Pediatric Hematology/oncology Research Interest DICER1 syndrome Wilms tumor Publications Featured Publications PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor. Tiburcio PDB, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS, Pediatr Blood Cancer 2025 Jun e31852 Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries. Harris AK, Nelson AT, Watson D, Mallinger PHR, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KAP, Cancer 2025 May 131 9 e35862 One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma. Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KAP, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD, Clin Cancer Res 2025 May Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor. Tiburcio PDB, Chen K, Xu L, Chen KS, Cell Rep Med 2025 May 6 5 102133 An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma. Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS, Genes Dev 2025 Apr Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell Tumor. Nelson AT, Watson D, Chen KS, Olson DR, Stall JN, Devins KM, Young RH, Kamihara J, Mallinger PHR, Kim J, Hatton JN, Messinger YH, Frazier AL, Stewart DR, Schneider DT, Harris AK, Dehner LP, Hill DA, Schultz KAP, JCO Precis Oncol 2025 Apr 9 e2400902 Pleuropulmonary blastoma and DICER1-related tumor predisposition: from clinicopathologic observations to clinical trial. Nelson AT, Chen KS, Schultz KAP, Curr Opin Pediatr 2025 Feb 37 1 48-55 Germline pathogenic DROSHA variants are linked to pineoblastoma and Wilms tumor predisposition. Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Saulnier Sholler G, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Williams Parsons D, Plon SE, Schultz KAP, Onel K, Clin Cancer Res 2025 Feb DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies. Schultz KAP, Nelson AT, Mallinger PHR, Harris AK, Kamihara J, Baldinger S, Chen KS, Pond D, Hatton JN, Dybvik A, Mitchell SG, Perrino MR, Ben-Ami T, Kachanov D, Su Y, Duan C, Olson DR, Watson D, Field AL, Harney LA, Garrity Carr A, Frazier AL, Schneider DT, Wilson DB, MacFarland SP, Schoettler PJ, Bauer AJ, Dehner LP, Hill DA, Stewart DR, Messinger YH, Clin Cancer Res 2024 Oct Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry. Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KAP, Pediatr Blood Cancer 2024 May e31090 Results 1-10 of 33 1 2 3 4 Next Last Honors & Awards CPRIT Recruitment of First-Time, Tenure-Track Faculty (2018-2023) Texas Super Doctors (Texas Rising Star)Texas Monthly (2018) UTSW Disease-Oriented Clinical Scholar (2018-2021) Alex's Lemonade Stand Foundation Young Investigator (2016-2019) Hyundai Hope on Wheels Young Investigator (2016-2018) Damon Runyon-Sohn Pediatric Cancer Fellow (2013-2017) W.W. Caruth ScholarChildrens Medical Center Foundation (2013-2015) First Place, Critical Appraisal of LiteratureResident Section Poster Contest, Texas Pediatric Society (2008) Professional Associations/Affiliations American Association for Cancer Research (2012) American Society of Pediatric Hematology and Oncology (2010) Children's Oncology Group (2010)
