Kenneth Chen, M.D. Titles and Appointments Assistant Professor Schools Medical School | Graduate School Departments Pediatrics | Children's Medical Center Research Institute at UT Southwestern Graduate Programs Cancer Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Kenneth S. Chen, M.D., is an Assistant Professor of Pediatrics and the Children's Medical Center Research Institute. He is an Attending Physician in the Gill Center for Cancer and Blood Disorders at Children’s Medical Center in Dallas. Dr. Chen received his B.S.E. in biomedical engineering from Johns Hopkins University and M.D. from UT Southwestern. He then completed pediatric residency and pediatric hematology-oncology fellowship at UT Southwestern, where he joined the laboratory of James F. Amatruda. As a physician-scientist, he divides his time between his research laboratory and Children’s Medical Center in Dallas, where he specializes in the care of children with cancer and blood disorders. His research interests in the laboratory focus on understanding the genetic drivers of childhood cancers, especially Wilms tumor, pleuropulmonary blastoma, and other cancers driven by mutations that impair microRNA processing. Education Medical School UT Southwestern Medical School (2006) Internship UT Southwestern/Children's Medical Center (2007), Pediatrics Residency UT Southwestern/Children's Medical Center (2009), Pediatrics Fellowship UT Southwestern/Children's Medical Center (2013), Pediatric Hematology/oncology Research Interest DICER1 syndrome Wilms tumor Publications Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults Flores-Toro J, Jagu S, Smith M, Shern J, Hawkins DS, Mardis ER, Rudzinski E, Alonzo TA, Beeles T, Ramirez N, Thomas DL, Cottrell CE, Parbhoo K, Janeway KA, Leary S, Fouladi M, Oberoi S, Venkatramani R, Irwin M, Laetsch TW, Chen KS, Bailey K, Davis JL, Sullivan MB, Boja E, Lowy D, Guidry Auvil JM, Wideman B, Kibbe W, Doroshow J, Reaman GH Journal of the National Cancer Institute 2026 Feb 118 199-204 Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee Englum BR, Piao J, Younis L, Baertschiger RM, Chen KS, Christison-Lagay E, Dholaria H, Gartrell R, Hicks MJ, Kamihara J, Mitchell SG, Orjuela-Grimm M, Pashankar F, Potter SL, Aldrink JH, Rosenblum J, Sargen MR, Schultz KA, Seynnaeve BK, Wedekind M, Laetsch TW Pediatric Blood and Cancer 2026 Feb 73 RAS pathway targeted therapy in patients with DICER1-associated sarcomas Zhang L, Mallinger PH, Zhou S, Makri SC, Gross JM, Lucas CH, Zou YS, Mize W, Olson DR, Munnikhuysen SR, Rawwas J, Messinger Y, Chen KS, Schultz KA, Pratilas CA npj Precision Oncology 2025 Dec 9 Feasibility of Atezolizumab in Combination With Chemotherapy for Children With Relapsed or Refractory Solid Tumors Campbell ME, Stutzman S, Primeaux S, Sida D, Lee M, Shah AT, Sadanand A, Sokol E, Collins NB, Turpin B, Navai S, Albert K, Laetsch TW, Rakheja D, Chen KS, Gerber DE, Koh AY Pediatric Blood and Cancer 2025 Dec 72 PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor Tiburcio PD, Desai K, Warne A, Nabbi A, Zhou S, Reiff SD, Campbell ME, Amatruda JF, Chen KS Pediatric Blood and Cancer 2025 Sep 72 One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KA, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD Clinical Cancer Research 2025 Aug 31 3124-3132 An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma Fraire CR, Desai K, Jagadeeswaran I, Obalapuram UA, Mendyka LK, Rajaram V, Sebastian T, Wang Y, Onel K, Lee J, Skapek SX, Chen KS Genes and Development 2025 Jun 39 727-750 Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor Tiburcio PD, Chen K, Xu L, Chen KS Cell Reports Medicine 2025 May 6 Ovarian juvenile granulosa cell tumor: A report from the International Ovarian and Testicular Stromal Tumor and International Pleuropulmonary Blastoma/DICER1 Registries Harris AK, Nelson AT, Watson D, Mallinger PH, Messinger YH, Frazier AL, Stering A, Snyder SL, Levy CF, Kamihara J, Herzog CE, Lagmay J, Foresto S, Chen KS, Devins KM, Young RH, Hill DA, Dehner LP, Tadavarthy AK, Stall JN, Billmire DF, Schneider DT, Schultz KA Cancer 2025 May 131 Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition Fiorica PN, Golmard L, Kim J, Bao R, Lin FY, Roy A, Pribnow A, Perrino MR, Masliah-Planchon J, Michalak-Provost S, Wong J, Filser M, Stoppa-Lyonnet D, Bourdeaut F, Brahimi A, Ingster O, Sholler GS, Jackson SA, Sasaki MM, Fowler T, Ng A, Corbett RJ, Kaufman RS, Haley JS, Carey DJ, Huang KL, Diskin SJ, Rokita JL, Al-Kateb H, McGee RB, Schiffman JD, Chen KS, Stewart DR, Parsons DW, Plon SE, Schultz KA, Onel K Clinical Cancer Research 2025 Apr 31 1491-1503 Results 1-10 of 40 1 2 3 4 Next Last Honors & Awards CPRIT Recruitment of First-Time, Tenure-Track Faculty (2018-2023) Texas Super Doctors (Texas Rising Star)Texas Monthly (2018) UTSW Disease-Oriented Clinical Scholar (2018-2021) Alex's Lemonade Stand Foundation Young Investigator (2016-2019) Hyundai Hope on Wheels Young Investigator (2016-2018) Damon Runyon-Sohn Pediatric Cancer Fellow (2013-2017) W.W. Caruth ScholarChildrens Medical Center Foundation (2013-2015) First Place, Critical Appraisal of LiteratureResident Section Poster Contest, Texas Pediatric Society (2008) Professional Associations/Affiliations American Association for Cancer Research (2012) American Society of Pediatric Hematology and Oncology (2010) Children's Oncology Group (2010)
