Eunsook Jin, Ph.D.

Eunsook S. Jin, PhD, is Assistant Professor at the advanced Imaging Research Center and Internal Medicine of UT Southwestern Medical Center. Dr. Jin is interested in intermediary metabolism in vivo using multiple stable isotopes and NMR analysis. She uses isolated organ perfusion and intact animal models, and recruit human subjects to study metabolism in the  liver, skeletal muscles or the heart. Her research interests are hepatic insulin resistance, hepatic oxidative stress, glucose-fat interaction, obesity, and type 2 diabetes. Most recently she is working on ¹³C asymmetry in blood glucose released from the liver given [U-¹³C₃]glycerol to determine if the asymmetry is sensitive to hepatic oxidative stress and the pentose phosphate pathway and transaldolase activities in the liver. 

Graduate School

Unlisted - International Colle (1990), Dental Science

Graduate School

University of Texas at Dallas (1998)

Graduate School

University of Texas at Dallas (2001), Chemistry

• Glucose-fat metabolic interaction
• Insulin resistance & Type 2 diabetes
• intermediary metabolism
• NMR

Featured Publications

Interaction between the Pentose Phosphate Pathway and Gluconeogenesis from Glycerol in the Liver.

Jin ES, Sherry AD, Malloy CR J. Biol. Chem. 2014 Oct

Influence of Liver Triglycerides on Suppression of Glucose Production by Insulin in Men.

Jin ES, Szuszkiewicz-Garcia M, Browning JD, Baxter JD, Abate N, Malloy CR J. Clin. Endocrinol. Metab. 2014 Sep jc20142404

Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.

Yang C, Harrison C, Jin ES, Chuang DT, Sherry AD, Malloy CR, Merritt ME, Deberardinis RJ J. Biol. Chem. 2014 Jan

Metabolism of Glycerol, Glucose and Lactate in the Citric Acid Cycle Prior to Incorporation into Hepatic Acylglycerols.

Jin ES, Sherry AD, Malloy CR J. Biol. Chem. 2013 Apr

Evidence for Transaldolase Activity in the Isolated Heart Supplied with [U-13C3]Glycerol.

Jin ES, Sherry AD, Malloy CR J. Biol. Chem. 2013 Feb 288 5 2914-22

Hepatic glucose production pathways after three days of a high-fat diet.

Jin ES, Beddow SA, Malloy CR, Samuel VT Metab. Clin. Exp. 2013 Jan 62 1 152-62

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ Nature 2012 Jan 481 7381 385-8

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.

Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR J. Clin. Invest. 2010 May 120 5 1494-505

Evidence for reverse flux through pyruvate kinase in skeletal muscle.

Jin ES, Sherry AD, Malloy CR Am. J. Physiol. Endocrinol. Metab. 2009 Apr 296 4 E748-57

The impact of obesity, sex, and diet on hepatic glucose production in cats.

Kley S, Hoenig M, Glushka J, Jin ES, Burgess SC, Waldron M, Jordan ET, Prestegard JH, Ferguson DC, Wu S, Olson DE Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009 Apr 296 4 R936-43

• R01
  NIH/NIDDK 13C asymmetry in blood glucose as a marker for oxidative stress in liver (2014)
• K01
  NIH/NIDDK Mentored Research Scientist Development Award (2008)