Steven Kliewer, Ph.D. Professor Endowed Title Diana K. and Richard C. Strauss Distinguished Chair in Developmental Biology School Medical School Department Molecular Biology | Pharmacology Graduate Programs Cell and Molecular Biology Biography Steven Kliewer earned his BS in biochemistry from Brown University in 1985 and his PhD in molecular biology from UCLA in 1990. From 1990-1993, he was a postdoctoral fellow at the Salk Institute, and from 1993-2002 he was a scientist at GlaxoSmithKline, rising to Director of Nuclear Receptor Research. In 2002, he joined UT Southwestern, where he is currently Professor of Molecular Biology and Pharmacology and holds the Diana K. and Richard C. Strauss Distinguished Chair in Developmental Biology. He is a member of the National Academy of Sciences. Dr. Kliewer runs a joint laboratory with Dr. David Mangelsdorf. Their research focuses on the roles of nuclear receptors and endocrine FGFs in regulating diverse aspects of physiology and pathophysiology, including metabolism and related diseases. Among their ongoing projects, they are studying how FGF19 and FGF21 regulate bile acid and energy homeostasis, respectively, and how the dafachronic acid receptor, DAF-12, regulates the infectious lifecycle of parasitic nematodes. Education Undergraduate Brown University (1985), Biochemistry Graduate School Uni of California (UCLA) (1990), Molecular Biology Research Interest Endocrine FGFs Metabolism and metabolic disease Nuclear receptors Publications Featured Publications Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21 Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA Cell Metab June 2007 5 415-25 Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A. Cell Metab November 2005 2 217-225 The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA J. Clin. Invest. 1998 Sep 102 5 1016-23 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Willson, T.M., and Kliewer, S.A. J. Biol. Chem 1995 270 12953-12956 The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes. Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA PLoS Genet. 2015 Mar 11 3 e1005027 FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss. Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ Cell Metab. 2014 Aug FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA Nat. Med. 2013 Aug FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ Science 2011 Mar 331 6024 1621-4 Results 1-8 of 8 1 Honors & Awards National Academy of Sciences (2015) Falk Foundation Adolf Windaus Prize (2014) Endocrine Society Ernst Oppenheimer Award (2005) Aventis Innovative Investigator Award (2004) ISSX North American New Investigator Award (2003) ASPET John J. Abel Award in Pharmacology (2002) Professional Associations/Affiliations American Society for Pharmacology and Experimental Therapeutics The Endocrine Society
