Biography

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Dr. Rosen is the Chair of the Department of Biophysics at UT Southwestern Medical Center and an Investigator of the Howard Hughes Medical Institute.  Dr. Rosen received undergraduate degrees in chemistry and in chemical engineering from the University of Michigan in 1987.  He then spent a year in Alan Battersby’s lab in the Department of Chemistry at the University of Cambridge as a Winston Churchill Foundation Scholar.  He received his Ph.D. in Chemistry from Harvard University in 1993 under the direction of Stuart Schreiber, where he studied the structure and function of the FK506 binding protein, FKBP12.  He was a Damon Runyon-Walter Winchell post-doctoral fellow in the laboratories of Tony Pawson and Lewis Kay at the University of Toronto, where he studied regulation of the signaling adaptor protein, Crk, and developed methods of selective methyl group labeling of proteins for NMR spectroscopy.  Dr. Rosen started his independent laboratory in 1996 in the Cellular Biochemistry and Biophysics Program at the Memorial Sloan-Kettering Cancer Center in New York City, and moved to UTSW in 2001. 

The Rosen lab seeks to understand the formation, regulation and functions of enigmatic, cellular compartments termed biomolecular condensates.  These evolutionarily conserved structures concentrate diverse but specific groups of molecules without a surrounding membrane.  Condensates appear to form through the physical process of liquid-liquid phase separation.  Using a range of techniques, including biochemical reconstitution and in vitro and cellular microsopies, we investigate phase separation in both engineered and natural condensates.  The former, in their simplified nature, enable precise isolation of key molecular parameters governing condensate behaviors, revealing general principles. The latter allow demonstration of these principles in more complex natural biochemical and cellular systems.  Ultimately, we seek to understand cell organization on scales spanning nanometers to microns.

The Rosen lab website can be found at:  www.utsouthwestern.edu/labs/rosen/

 

Education

Undergraduate
University of Michigan-Ann Arb (1987), Chemical Engineering
Undergraduate
University of Michigan-Ann Arb (1987), Chemistry
Graduate School
Harvard University (1993), Organic Chemistry

Research Interest

  • biochemistry
  • Biological phase separation
  • cell biology of the actin cytoskeleton
  • polymer physics/chemistry
  • structural biology

Publications

Featured Publications LegendFeatured Publications

Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton.
Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S, Way M Dev. Cell 2014 Sep 30 5 569-84
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.
McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ Curr. Biol. 2014 Jul 24 14 1670-6
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.
McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ Curr. Biol. 2014 Jul 24 14 1678
Local F-actin Network Links Synapse Formation and Axon Branching.
Chia PH, Chen B, Li P, Rosen MK, Shen K Cell 2014 Jan 156 1-2 208-20
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK Cell 2014 Jan 156 1-2 195-207
Biochemical reconstitution of the WAVE regulatory complex.
Chen B, Padrick SB, Henry L, Rosen MK Meth. Enzymol. 2014 540 55-72
The Haemophilus ducreyi LspA1 Protein Inhibits Phagocytosis By Using a New Mechanism Involving Activation of C-Terminal Src Kinase.
Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ MBio 2014 5 3
The bacterial effector VopL organizes actin into filament-like structures.
Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK Cell 2013 Oct 155 2 423-34
Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination.
Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR Cell 2013 Feb 152 5 1051-64
Measurement and analysis of in vitro actin polymerization.
Doolittle LK, Rosen MK, Padrick SB Methods Mol. Biol. 2013 1046 273-93

Honors & Awards

  • Allen Distinguished Investigator, a program funded through The Paul G. Allen Frontiers Group
    (2018-2021)
  • Emil Kaiser Award, Protein Society
    (2018)
  • Mar Nell and F. Andrew Bell Distinguished Chair in Biochemistry
    (2009)
  • Carolyn R. Bacon Professorship in Medical Science and Education
    (2006)
  • Edith & Peter O’Donnell Award from the Texas Academy of Medicine, Engineering and Science
    (2006)
  • Howard Hughes Medical Institute
    (2005)
  • Boyer Award, Memorial Sloan-Kettering Cancer Center
    (2001)
  • Sidney Kimmel Scholar Award
    (1998)
  • Beckman Young Investigator
    (1997)
  • Presidential Early Career Award for Scientists and Engineers (PECASE)
    (1997)
  • Winston Churchill Scholar
    (1987)