Biography

Download Curriculum Vitae

Dr. Rosen is the Chair of the Department of Biophysics at UT Southwestern Medical Center and an Investigator of the Howard Hughes Medical Institute.  Dr. Rosen received undergraduate degrees in chemistry and in chemical engineering from the University of Michigan in 1987.  He then spent a year in Alan Battersby’s lab in the Department of Chemistry at the University of Cambridge as a Winston Churchill Foundation Scholar.  He received his Ph.D. in Chemistry from Harvard University in 1993 under the direction of Stuart Schreiber, where he studied the structure and function of the FK506 binding protein, FKBP12.  He was a Damon Runyon-Walter Winchell post-doctoral fellow in the laboratories of Tony Pawson and Lewis Kay at the University of Toronto, where he studied regulation of the signaling adaptor protein, Crk, and developed methods of selective methyl group labeling of proteins for NMR spectroscopy.  Dr. Rosen started his independent laboratory in 1996 in the Cellular Biochemistry and Biophysics Program at the Memorial Sloan-Kettering Cancer Center in New York City, and moved to UTSW in 2001.  For a number of years Dr. Rosen’s research program focused on the structural biology and biochemistry of the Rho GTPase signaling pathways that control actin dynamics.  More recently his lab has changed direction to study the mechanisms and functions of biomolecular phase separation, providing novel insights into eukaryotic cell organization on micron length scales.

The Rosen lab website can be found at:  www.utsouthwestern.edu/labs/rosen/

 

Education

Undergraduate
University of Michigan-Ann Arb (1987), Chemistry
Undergraduate
University of Michigan-Ann Arb (1987), Chemical Engineering
Graduate School
Harvard University (1993), Organic Chemistry

Research Interest

  • biochemistry
  • cell biology of the actin cytoskeleton
  • polymer physics/chemistry
  • structural biology

Publications

Featured Publications LegendFeatured Publications

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM Cell 2018 Apr 173 3 693-705.e22
Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.
Huang WYC, Ditlev JA, Chiang HK, Rosen MK, Groves JT J. Am. Chem. Soc. 2017 Nov
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.
Harmon TS, Holehouse AS, Rosen MK, Pappu RV Elife 2017 Nov 6

Honors & Awards

  • Mar Nell and F. Andrew Bell Distinguished Chair in Biochemistry
    (2009)
  • Carolyn R. Bacon Professorship in Medical Science and Education
    (2006)
  • Edith & Peter O’Donnell Award from the Texas Academy of Medicine, Engineering and Science
    (2006)
  • Howard Hughes Medical Institute
    (2005)
  • Sidney Kimmel Scholar Award
    (1998)
  • Beckman Young Investigator
    (1997)
  • Presidential Early Career Award for Scientists and Engineers (PECASE)
    (1997)
  • Winston Churchill Scholar
    (1987)