Biography

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Dr. Rosen is the Chair of the Department of Biophysics at UT Southwestern Medical Center and an Investigator of the Howard Hughes Medical Institute.  Dr. Rosen received undergraduate degrees in chemistry and in chemical engineering from the University of Michigan in 1987.  He then spent a year in Alan Battersby’s lab in the Department of Chemistry at the University of Cambridge as a Winston Churchill Foundation Scholar.  He received his Ph.D. in Chemistry from Harvard University in 1993 under the direction of Stuart Schreiber, where he studied the structure and function of the FK506 binding protein, FKBP12.  He was a Damon Runyon-Walter Winchell post-doctoral fellow in the laboratories of Tony Pawson and Lewis Kay at the University of Toronto, where he studied regulation of the signaling adaptor protein, Crk, and developed methods of selective methyl group labeling of proteins for NMR spectroscopy.  Dr. Rosen started his independent laboratory in 1996 in the Cellular Biochemistry and Biophysics Program at the Memorial Sloan-Kettering Cancer Center in New York City, and moved to UTSW in 2001. 

The Rosen lab seeks to understand the formation, regulation and functions of enigmatic, cellular compartments termed biomolecular condensates.  These evolutionarily conserved structures concentrate diverse but specific groups of molecules without a surrounding membrane.  Condensates appear to form through the physical process of liquid-liquid phase separation.  Using a range of techniques, including biochemical reconstitution and in vitro and cellular microsopies, we investigate phase separation in both engineered and natural condensates.  The former, in their simplified nature, enable precise isolation of key molecular parameters governing condensate behaviors, revealing general principles. The latter allow demonstration of these principles in more complex natural biochemical and cellular systems.  Ultimately, we seeks to understand cell organization on scales spanning nanometers to microns.

The Rosen lab website can be found at:  www.utsouthwestern.edu/labs/rosen/

 

Education

Undergraduate
University of Michigan-Ann Arb (1987), Chemical Engineering
Undergraduate
University of Michigan-Ann Arb (1987), Chemistry
Graduate School
Harvard University (1993), Organic Chemistry

Research Interest

  • biochemistry
  • Biological phase separation
  • cell biology of the actin cytoskeleton
  • polymer physics/chemistry
  • structural biology

Publications

Featured Publications LegendFeatured Publications

Who's in and Who's Out-Compositional Control of Biomolecular Condensates.
Ditlev JA, Case LB, Rosen MK J. Mol. Biol. 2018 Aug
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM Cell 2018 Apr 173 3 693-705.e22
Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly.
Protter DSW, Rao BS, Van Treeck B, Lin Y, Mizoue L, Rosen MK, Parker R Cell Rep 2018 Feb 22 6 1401-1412

Honors & Awards

  • Mar Nell and F. Andrew Bell Distinguished Chair in Biochemistry
    (2009)
  • Carolyn R. Bacon Professorship in Medical Science and Education
    (2006)
  • Edith & Peter O’Donnell Award from the Texas Academy of Medicine, Engineering and Science
    (2006)
  • Howard Hughes Medical Institute
    (2005)
  • Sidney Kimmel Scholar Award
    (1998)
  • Beckman Young Investigator
    (1997)
  • Presidential Early Career Award for Scientists and Engineers (PECASE)
    (1997)
  • Winston Churchill Scholar
    (1987)