Dr. Chook received an AB degree in Chemistry and Biology (major at Haverford College) from Bryn Mawr College in 1988. She received a PhD in Biophysics in 1994 from Harvard University, where she studied the structures and mechanism of chorismate mutase with William Lipscomb. Her postdoctoral work was with Emil Pai and Tony Pawson in Toronto studying signal transduction in the Ras pathway, and with Günter Blobel at the Rockefeller University studying the mechanisms of nuclear import.
In December of 2001, Dr Chook joined the Department of Pharmacology at UT Southwestern as an Assistant Professor and Eugene McDermott Scholar in Biomedical Research. The Chook laboratory aims to understand mechanisms of nucleocytoplasmic transport and molecular recognition by the Karyopherin-β nuclear transport receptors (Kaps; Importins and Exportins), classify nuclear traffic, and discover how Kapβs organize and regulate cellular functions. They seek to discover these roles of Kaps through a combination of structural, biochemical, biophysical, bioinformatics and cell biological investigations focused on Kap-cargo interactions.
- Graduate School
- Bryn Mawr College , Biology
- Graduate School
- Bryn Mawr College , Chemistry
- Graduate School
- Harvard University (1993)
- Cell Biology
- Protein transport, nucleocytoplasmic transport, targeting signals
- Structural Biology
- Karyopherins in cancer.
- Çagatay T, Chook YM Curr. Opin. Cell Biol. 2018 Jan 52 30-42
- Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
- Fung HY, Fu SC, Chook YM Elife 2017 Mar 6
- Karyopherin-ß2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.
- Soniat M, Chook YM Structure 2016 Sep
- Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
- Hing ZA, Fung HY, Ranganathan P, Mitchell S, El-Gamal D, Woyach JA, Williams K, Goettl VM, Smith J, Yu X, Meng X, Sun Q, Cagatay T, Lehman AM, Lucas DM, Baloglu E, Shacham S, Kauffman MG, Byrd JC, Chook YM, Garzon R, Lapalombella R Leukemia 2016 Jun
- Structural determinants of nuclear export signal orientation in binding CRM1.
- Fung HY, Fu SC, Brautigam CA, Chook YM Elife 2015 Sep 4
- Nuclear localization signals for four distinct karyopherin-ß nuclear import systems.
- Soniat M, Chook YM Biochem. J. 2015 Jun 468 3 353-62
- LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.
- Xu D, Marquis K, Pei J, Fu SC, Cagatay T, Grishin NV, Chook YM Bioinformatics 2014 Dec
- Atomic basis of CRM1-cargo recognition, release and inhibition.
- Fung HY, Chook YM Semin. Cancer Biol. 2014 Mar
- Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
- Sun Q, Carrasco YP, Hu Y, Guo X, Mirzaei H, Macmillan J, Chook YM Proc. Natl. Acad. Sci. U.S.A. 2013 Jan
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
- Lapalombella R, Sun Q, Williams K, Tangeman L, Jha S, Zhong Y, Goettl V, Mahoney E, Berglund C, Gupta S, Farmer A, Mani R, Johnson AJ, Lucas D, Mo X, Daelemans D, Sandanayaka V, Shechter S, McCauley D, Shacham S, Kauffman M, Chook YM, Byrd JC Blood 2012 Nov 120 23 4621-34
Chorismate Mutase, essentially a template enzyme. Chapter 17, 235-244.. In Biological NMR Spectroscopy. John L. Markley, Stanley Opella and Richard Ernst (editors).
Lipscomb, W.N., Chook, Y.M. and Ke, H. (1997). Oxford University Press.
Structural Analysis of Karyopherin-mediated nucleocytoplasmic transport.. In Nuclear Transport, edited by Ralph Kehlenbach.
Zhang, Z. C. and Chook, Y. M. (2009). Landes Bioscience.
Honors & Awards
- Alfred and Mabel Gilman Chair in Molecular Pharmacology
- The Edith and Peter ODonnell Award in Science
Texas Academy of Medicine, Engineering and Science (2015)
- Leukemia and Lymphoma Society Scholar Award
- Eugene McDermott Scholar in Biomedical Research
U.T. Southwestern Endowed Scholar Award (2001)
- Life Sciences Research Foundation Postdoctoral Fellowship
Rockefeller University (1996)
- Human Frontiers in Science Program Postdoctoral Fellowship
University of Toronto/Mount Sinai Hospital (1994)
- Certificate of Distinction in Teaching
Harvard-Danforth Center for Teaching and Learning, Harvard University (1990)