Education

Undergraduate
Unlisted - International Colle (1988)
Graduate School
Northwestern University (1991)
Graduate School
University of Calgary - Canada (1996)

Research Interest

  • Alzheimer disease
  • Cell and Molecular Biology
  • Gamma-secretase
  • Neurodegeneration
  • Neuroscience

Publications

Featured Publications LegendFeatured Publications

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, George-Hyslop PS J. Biol. Chem. 2000 Sep 275 35 27348-53
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P Nature 2000 Sep 407 6800 48-54
An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Song Y, Hill DL, Abou-Donia SM, Martin ER, Vance JJ, Yu G, Orlacchio A, Pei Y, Nishimura M, Supala A, Roberge B, Saunders AM, Roses AD, Schmechel D, Crane-Gatherum A, Sorbi S, Bruni A, Small GW, Conneally PM, Haines JL, Van Leuven F, St George-Hyslop PH, Farrer LA, Pericak-Vance MA Nat. Genet. 1999 May 22 1 19-22
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, St George-Hyslop P Nat. Med. 1999 Feb 5 2 164-9
Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
Rogaeva E, Premkumar S, Song Y, Sorbi S, Brindle N, Paterson A, Duara R, Levesque G, Yu G, Nishimura M, Ikeda M, O'Toole C, Kawarai T, Jorge R, Vilarino D, Bruni AC, Farrer LA, St George-Hyslop PH JAMA 1998 Aug 280 7 614-8
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St George-Hyslop PH, Fraser PE J. Biol. Chem. 1998 Jun 273 26 16470-5
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P Hum. Mol. Genet. 1998 May 7 5 933-5

Honors & Awards

  • Award for Excellence in Postdoctoral Mentoring
    (2010)
  • Ruth K. Broad Research Foundation Award
    (2006)
  • Ruth Salta Junior Investigator Achievement Award
    (2005)
  • Alzheimer Disease Research Award
    (2003)
  • Natalie Ornish Award
    (2002)
  • Thomas O. Hicks Scholar in Medical Research
    (2001)
  • Memorial Frist/Jus Research Award
    (1998)

Professional Associations/Affiliations

  • American Society of Biochemistry and molecular biology (2010)
  • Editorial Board, Journal of Biological Chemistry (2010-2016)
  • Society for Neuroscience (2002)