Unlisted - International Colle (1988)
Graduate School
Northwestern University (1991)
Graduate School
University of Calgary - Canada (1996)

Research Interest

  • Alzheimer disease
  • Cell and Molecular Biology
  • Gamma-secretase
  • Neurodegeneration
  • Neuroscience


Featured Publications LegendFeatured Publications

sorLA: sorting out APP.
Shah S, Yu G Mol. Interv. 2006 Apr 6 2 74-6, 58
Nicastrin functions as a gamma-secretase-substrate receptor.
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, S├╝dhof T, Yu G Cell 2005 Aug 122 3 435-47
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.
Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G J. Biol. Chem. 2004 Feb 279 6 4144-52
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H J. Biol. Chem. 2003 Mar 278 10 7850-4
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF, Shah S, Li H, Yu C, Han W, Yu G J. Biol. Chem. 2002 Nov 277 47 45013-9
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P Proc. Natl. Acad. Sci. U.S.A. 2002 Oct 99 22 14452-7
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, Fraser PE J. Biol. Chem. 2002 Aug 277 31 28135-42
Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P Neurobiol. Aging 2002 Mar-Apr 23 2 187-94
APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.
Levitan D, Yu G, St George Hyslop P, Goutte C Dev. Biol. 2001 Dec 240 2 654-61
Nicastrin binds to membrane-tethered Notch.
Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH Nat. Cell Biol. 2001 Aug 3 8 751-4

Honors & Awards

  • Award for Excellence in Postdoctoral Mentoring
  • Ruth K. Broad Research Foundation Award
  • Ruth Salta Junior Investigator Achievement Award
  • Alzheimer Disease Research Award
  • Natalie Ornish Award
  • Thomas O. Hicks Scholar in Medical Research
  • Memorial Frist/Jus Research Award

Professional Associations/Affiliations

  • American Society of Biochemistry and molecular biology (2010)
  • Editorial Board, Journal of Biological Chemistry (2010-2016)
  • Society for Neuroscience (2002)