Education

Undergraduate
Unlisted - International Colle (1988)
Graduate School
Northwestern University (1991)
Graduate School
University of Calgary - Canada (1996)

Research Interest

  • Alzheimer disease
  • Cell and Molecular Biology
  • Gamma-secretase
  • Neurodegeneration
  • Neuroscience

Publications

Featured Publications LegendFeatured Publications

{gamma}-Secretase-regulated Proteolysis of the Notch Receptor by Mitochondrial Intermediate Peptidase.
Lee SF, Srinivasan B, Sephton CF, Dries DR, Wang B, Yu C, Wang Y, Dewey CM, Shah S, Jiang J, Yu G J. Biol. Chem. 2011 Aug 286 31 27447-53
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J J. Biol. Chem. 2011 May 286 18 16101-8
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Dewey CM, Cenik B, Sephton CF, Dries DR, Mayer P, Good SK, Johnson BA, Herz J, Yu G Mol. Cell. Biol. 2011 Mar 31 5 1098-108
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G J. Biol. Chem. 2011 Jan 286 2 1204-15
Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2.
Mayer PR, Huang N, Dewey CM, Dries DR, Zhang H, Yu G J. Biol. Chem. 2010 Dec 285 51 40387-96
TDP-43 is a developmentally regulated protein essential for early embryonic development.
Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P, Herz J, Yu G J. Biol. Chem. 2010 Feb 285 9 6826-34
Glu-333 of nicastrin directly participates in gamma-secretase activity.
Dries DR, Shah S, Han YH, Yu C, Yu S, Shearman MS, Yu G J. Biol. Chem. 2009 Oct 284 43 29714-24
Rip exposed: how ectodomain shedding regulates the proteolytic processing of transmembrane substrates.
Dries DR, Yu G Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 106 35 14737-8
Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.
Dries DR, Yu G Curr Alzheimer Res 2008 Apr 5 2 132-46
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I Cell 2006 Sep 126 5 981-93

Honors & Awards

  • Award for Excellence in Postdoctoral Mentoring
    (2010)
  • Ruth K. Broad Research Foundation Award
    (2006)
  • Ruth Salta Junior Investigator Achievement Award
    (2005)
  • Alzheimer Disease Research Award
    (2003)
  • Natalie Ornish Award
    (2002)
  • Thomas O. Hicks Scholar in Medical Research
    (2001)
  • Memorial Frist/Jus Research Award
    (1998)

Professional Associations/Affiliations

  • American Society of Biochemistry and molecular biology (2010)
  • Editorial Board, Journal of Biological Chemistry (2010-2016)
  • Society for Neuroscience (2002)