Gang Yu, Ph.D.

• Alzheimer disease
• Cell and Molecular Biology
• Gamma-secretase
• Neurodegeneration
• Neuroscience

 Featured Publications

Breathing new life into the rational design of Alzheimer's therapeutics.

Dries DR, Yu G, Cell 2021 Jan 184 2 296-298

Essential requirement for nicastrin in marginal zone and B-1 B cell development.

Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B, Proc. Natl. Acad. Sci. U.S.A. 2020 Feb

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.

Bai B, Wang X, Li Y, Chen PC, Yu K, Dey KK, Yarbro JM, Han X, Lutz BM, Rao S, Jiao Y, Sifford JM, Han J, Wang M, Tan H, Shaw TI, Cho JH, Zhou S, Wang H, Niu M, Mancieri A, Messler KA, Sun X, Wu Z, Pagala V, High AA, Bi W, Zhang H, Chi H, Haroutunian V, Zhang B, Beach TG, Yu G, Peng J, Neuron 2020 Jan

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.

Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G J. Biol. Chem. 2016 Mar

Activity-dependent FUS dysregulation disrupts synaptic homeostasis.

Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G Proc. Natl. Acad. Sci. U.S.A. 2014 Oct

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.

Dewey CM, Cenik B, Sephton CF, Dries DR, Mayer P, Good SK, Johnson BA, Herz J, Yu G Mol. Cell. Biol. 2011 Mar 31 5 1098-108

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.

Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G J. Biol. Chem. 2011 Jan 286 2 1204-15

TDP-43 is a developmentally regulated protein essential for early embryonic development.

Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P, Herz J, Yu G J. Biol. Chem. 2010 Feb 285 9 6826-34

Nicastrin functions as a gamma-secretase-substrate receptor.

Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, Südhof T, Yu G Cell 2005 Aug 122 3 435-47

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P Nature 2000 Sep 407 6800 48-54

• Award for Excellence in Postdoctoral Mentoring
  (2010)
• Ruth K. Broad Research Foundation Award
  (2006)
• Ruth Salta Junior Investigator Achievement Award
  (2005)
• Alzheimer Disease Research Award
  (2003)
• Natalie Ornish Award
  (2002)
• Thomas O. Hicks Scholar in Medical Research
  (2001)
• Memorial Frist/Jus Research Award
  (1998)

• American Society of Biochemistry and molecular biology (2010)
• Editorial Board, Journal of Biological Chemistry (2010-2016)
• Society for Neuroscience (2002)