Education

Undergraduate
Texas A&M University (1984), Biochemistry
Graduate School
Uni of California (UCLA) (1986), Biochemistry
Graduate School
Univ of Tx Southwestern Med Ct (1993), Molecular Biology

Research Interest

  • Biochemistry
  • Cellular Signaling
  • Molecular Microbiology

Publications

Featured Publications LegendFeatured Publications

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. Science January 2009 323 269-272
Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways
Yi-Heng Hao,, Yong Wang, Dara Burdette, Sohini Mukherjee, Gladys Keitany, Elizabeth Goldsmith & Kim Orth PLoS ONE January 2008 3(1) e1375
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding and then cell lyses.
Burdette, D., Yarbrough, M., Orvedahl, A., Gilpin, C. & Orth, K. PNAS USA 2008 105 12497-12502
Arp2/3 Independent Assembly of Actin by Vibrio Type III Effector VopL
Amy D.B. Liverman, Hui-Chun Cheng, Jennifer E. Trosky, Daisy W. Leung, Melanie L. Yarbrough, Dara L. Burdette, Michael K. Rosen and Kim Orth PNAS (USA) October 2007 104:43 17117-17122
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Preventing Phosphorylation
Mukherjee, S. Kietany, G., Li, Y Wang, Y., Hall B.E., Goldsmith, E & Orth, K Science 2006 312 1211-1214

Honors & Awards

  • ASBMB Merck Award
    (2018)
  • American Academy of Microbiology
    Fellow (2016)
  • HHMI
    Investigator (2015)
  • Earl A. Forsythe Chair in Biomedical Science
    (2013)
  • ASBMB Young Investigator Award
    (2012)
  • TAMEST; 2011 Edith & Peter O'Donnell Award in Science
    (2011)
  • The Welch Foundation Norman Hackerman Award in Chemical Research
    (2010)
  • Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
    (2006)
  • Arnold and Mabel Beckman Young Investigator Award
    (2003)
  • W.W. Caruth, Jr. Scholar in Biomedical Research, UTSWMC
    (2001)