Education

Undergraduate
Texas A&M University (1984), Biochemistry
Graduate School
Uni of California (UCLA) (1986), Biochemistry
Graduate School
Univ of Tx Southwestern Med Ct (1993), Molecular Biology

Research Interest

  • Biochemistry
  • Cellular Signaling
  • Molecular Microbiology

Publications

Featured Publications LegendFeatured Publications

Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio.
de Souza Santos M, Orth K Cell. Microbiol. 2015 Feb 17 2 164-73
Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes.
Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ Proc. Natl. Acad. Sci. U.S.A. 2015 Jan 112 1 100-5
Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence.
Calder T, de Souza Santos M, Attah V, Klimko J, Fernandez J, Salomon D, Krachler AM, Orth K FEMS Microbiol. Lett. 2014 Dec 361 2 107-14
Unfolded protein response-regulated dFic reversibly AMPylates BiP during endoplasmic reticulum homeostasis.
Ham H, Woolery AR, Tracy C, Stenesen D, Krämer H, Orth K J. Biol. Chem. 2014 Nov
AMPylation of Rho GTPases subverts multiple host signaling processes.
Woolery AR, Yu X, LaBaer J, Orth K J. Biol. Chem. 2014 Nov 289 47 32977-88
Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells.
de Souza Santos M, Orth K MBio 2014 Sep 5 5 e01506-14
Type III effector VopC mediates invasion for Vibrio species.
Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K Cell Rep 2012 May 1 5 453-60
A Vibrio Effector Protein is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity
Broberg, C. A., Zhang, L.L., Gonzalez, H., Laskowski-Arce, M.A. & Orth, K Science September 2010 329 1660-1662
VopS Fic Domain uses direct transfer mechanism for AMPylation.
Luong, P., Kinch, L.N., Brautigam, C.A., Grishin, N.V., Tomchick, D.R. & Orth, K Journal of Biological Chemistry June 2010 285(26) 20155-20163
Vibrio VopQ Induces PI3-Kinase Independent Autophagy and Antagonizes Phagocytosis.
Burdette, D., Seemann, J. & Orth, K Molecular Microbiology August 2009 73 639-649

Honors & Awards

  • ASBMB Merck Award
    (2018)
  • American Academy of Microbiology
    Fellow (2016)
  • HHMI
    Investigator (2015)
  • Earl A. Forsythe Chair in Biomedical Science
    (2013)
  • ASBMB Young Investigator Award
    (2012)
  • TAMEST; 2011 Edith & Peter O'Donnell Award in Science
    (2011)
  • The Welch Foundation Norman Hackerman Award in Chemical Research
    (2010)
  • Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
    (2006)
  • Arnold and Mabel Beckman Young Investigator Award
    (2003)
  • W.W. Caruth, Jr. Scholar in Biomedical Research, UTSWMC
    (2001)