Kim Orth, Ph.D. Professor Endowed Title Earl A. Forsythe Chair in Biomedical Science; W.W. Caruth, Jr. Scholar in Biomedical Research School Medical School Department Molecular Biology | Biochemistry Graduate Programs Biological Chemistry, Molecular Microbiology Biography Download Curriculum Vitae Kim Orth Investigator, HHMI Professor, Department of Molecular Biology HHMI, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Room# NA5-120F, Dallas, Texas, 75390-9148. email: kim.orth@utsouthwestern.edu Office Phone: 214-648-1685; FAX: 214-648-1488 Personal Statement My laboratory is very active in elucidating mechanisms used by virulence factors expressed by bacterial pathogens. Studies using microbial genetics, biochemistry, cell biology and bioinformatics on effectors from Yersinia and Vibrio have uncovered many mechanisms that bacteria use to subvert host signaling pathways, including the discovery of two novel post translational modifications: YopJ Ser/Thr Acetylation and VopS AMPylation. We continue to study virulence mechanisms used by Vibrio parahaemolyticus T3SSs. My program has been ideal for training students and fostering new and creative ideas using rigorous methodology and analysis to test hypothesis driven basic science research. We also invest in satellite programs analyzing environmental Vibrios, metazoan AMPylation, rice blast and cancer cell exosomes. Over the years, I have contributed to varies programs for “Woman in Science”, including panel discussions for woman at American Society for Biochemistry and Molecular Biology (2017,2018), group discussion at Gordon Research Conference on Microbial Toxins and Pathogenesis (2018) and group sessions at FASEB meetings (2015, 2017, 2019 and in the future 2021). For my ASBMB Merck Award (2018), I wrote a solicited, personal reflection on my path in science for the Journal of Biological Chemistry to provide tools for younger scientists. This year, in light of COVID-19, I helped co-host two virtual international meetings: VibriOnline, May, 2020 and AMPylationPlus, July, 2020. Education Undergraduate Texas A&M University (1984), Biochemistry Graduate School Uni of California (UCLA) (1986), Biochemistry Graduate School Univ of Tx Southwestern Med Ct (1993), Molecular Biology Research Interest Biochemistry Cellular Signaling Molecular Microbiology Publications Featured Publications Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress. Chimalapati S, de Souza Santos M, Lafrance AE, Ray A, Lee WR, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K, Elife 2020 08 9 A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K, Nat. Struct. Mol. Biol. 2020 May My winding trail while fulfilling my love for science and family. Orth K J. Biol. Chem. 2018 Jul 293 27 10435-10437 Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K J. Biol. Chem. 2018 Feb 293 5 1550 Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration. Moehlman AT, Casey AK, Servage K, Orth K, Krämer H. eLife 2018 17;7. pii: e38752. doi: 10.7554/eLife.38752. [Epub ahead of print] Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K J. Biol. Chem. 2017 12 292 51 21193-21204 Bile salt receptor complex activates a pathogenic type III secretion system. Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K Elife 2016 5 AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. Science January 2009 323 269-272 Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria. Kinch LN, Cong Q, Jaishankar J, Orth K, Proc Natl Acad Sci U S A 2022 Jun 119 24 e2203176119 Beth Levine M.D. Prize in Autophagy Research. Vitetta ES, Cobb MH, Hobbs HH, Hooper L, Morrison SJ, Orth K, Pfeiffer J, Rosen MK, Takahashi JS, Wang T, Autophagy 2021 Aug 1 Results 1-10 of 92 1 2 3 4 5 Next Last Honors & Awards American Association for the Advancement of Science (2022) ASBMBFellow (2022) American Society of Microbiology Distinguish Lecturer (2021-2023) Elected to the National Academy of Sciences (2020) The Academy of Medicine, Engineering and Science of TexasMember (2020) Nirit and Michael Shaoul Visiting Scholar, Tel Aviv University (2019) ASBMB Merck Award (2018) American Academy of MicrobiologyFellow (2016) HHMIInvestigator (2015) Earl A. Forsythe Chair in Biomedical Science (2013) ASBMB Young Investigator Award (2012) TAMEST; 2011 Edith & Peter O'Donnell Award in Science (2011) The Welch Foundation Norman Hackerman Award in Chemical Research (2010) Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease (2006) Arnold and Mabel Beckman Young Investigator Award (2003) W.W. Caruth, Jr. Scholar in Biomedical Research, UTSWMC (2001)
