Alagarraju Muthukumar, Ph.D.

     

Dr. Kumar has a Masters and PhD in Biochemistry. He has completed clinical fellowships in clinical chemistry and molecular diagnostics at UT Southwestern Medical Center in Dallas. He had worked in the clinical diagnostic industry for 4 years before moving back to academia. He is a board certified Clinical chemist, and is currently the Medical Director of Clinical Chemistry at the Clements University Hospital, Zale Lipshy University hospital, Simmons Comprehensive Cancer Center, Moncrief Cancer Institute in Fort Worth, and the UT Southwestern Clinics in Plano and Richardson.

His research interests include validating new diagnostic assays, repurposing big data for clinical research, and finding new applications for existing diagnostic markers. Current ongoing projects in his labs include the assessment of humoral immune response to SARS-CoV-2 vaccines and a collaboration with Johns Hopkins University on the evaluation of clinical implications of LDL under-estimation in Coronary Heart Disease patients.

Medical School

Madras University Medical School (1996)

Other Post Graduate Training

Foreign Credentials Service of America (1996)

Graduate School

Foreign Credentials Service of America (1996)

Fellowship

UT Southwestern Medical Center (2006)

Fellowship

UT Southwestern Medical Center (2007)

• Repurposing of big data for clinical research
• Validation of new diagnostic assays

Featured Publications

Methods of Low-Density Lipoprotein-Cholesterol Measurement: Analytical and Clinical Applications.

Islam SMT, Osa-Andrews B, Jones PM, Muthukumar AR, Hashim I, Cao J, EJIFCC 2022 Dec 33 4 282-294

Ivabradine toxicity: a case report.

Singh K, Alagarraju MR, Wolf CE, Poklis JL, Kulkarni N, Tharpe W, Joshi PH, J Med Case Rep 2022 Oct 16 1 392

Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern.

Clark AE, Wang Z, Ostman E, Zheng H, Yao H, Cantarel B, Kanchwala M, Xing C, Chen L, Irwin P, Xu Y, Oliver D, Lee FM, Gagan JR, Filkins L, Muthukumar A, Park JY, Sarode R, SoRelle JA, Clin Chem 2022 May

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.

Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, Allen C, Sun Y, Venkatesan M, Madaris TR, Chiem K, Truitt R, Vishnu N, Aune G, Anderson A, Martinez L, Yang W, Stockand JD, Singh BB, Srikantan S, Reeves WB, Madesh M, iScience 2022 Jan 25 1 103722

Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group.

Kim K, Narasimhan M, Mahimainathan L, Zhang R, Araj E, Kim E, Tharpe W, Greenberg BM, Greenberg DE, Li QZ, Cheng CA, Sarode R, Malladi S, Muthukumar A, Front Immunol 2022 13 1020165

SARS-CoV-2 coinfections with variant genomic lineages identified by multiplex fragment analysis.

Lueking R, Clark AE, Narasimhan M, Mahimainathan L, Muthukumar A, Larsen CP, SoRelle JA, Front Genet 2022 13 942713

Population-based correlates of COVID-19 infection: An analysis from the DFW COVID-19 prevalence study.

Singal AG, Masica A, Esselink K, Murphy CC, Dever JA, Reczek A, Bensen M, Mack N, Stutts E, Ridenhour JL, Galt E, Brainerd J, Kopplin N, Yekkaluri S, Rubio C, Anderson S, Jan K, Whitworth N, Wagner J, Allen S, Muthukumar AR, Tiro J, PLoS One 2022 17 12 e0278335

Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels.

Sajja A, Park J, Sathiyakumar V, Varghese B, Pallazola VA, Marvel FA, Kulkarni K, Muthukumar A, Joshi PH, Gianos E, Hirsh B, Mintz G, Goldberg A, Morris PB, Sharma G, Blumenthal RS, Michos ED, Post WS, Elshazly MB, Jones SR, Martin SS, JAMA Netw Open 2021 Oct 4 10 e2128817

Poor Humoral Response in Solid Organ Transplant Recipients following Complete mRNA SARS-CoV-2 Vaccination.

Cao J, Liu X, Muthukumar A, Gagan J, Jones P, Zu Y, Clin Chem 2021 Aug

Myocarditis Temporally Associated with COVID-19 Vaccination.

Rosner CM, Genovese L, Tehrani BN, Atkins M, Bakhshi H, Chaudhri S, Damluji AA, de Lemos JA, Desai SS, Emaminia A, Flanagan MC, Khera A, Maghsoudi A, Mekonnen G, Muthukumar A, Saeed IM, Sherwood MW, Sinha SS, O'Connor CM, deFilippi CR, Circulation 2021 Jun

• Best Poster Finalist
  Systematic Analysis of Biotin Interference in Roche Chemistry Assays. ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017
• Best Poster Finalist
  Are all creatinine results suspect during Dopamine and Debutamine infusions? ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017
• Distinguished Abstract award
  Susceptability of High Sensitivity Cardiac Troponin I and Gen 5 cTnT assays to Biotin interference. 70th AACC Annual Meeting, Chicago, IL. July 29 - August 2, 2018

• American Association of Clinical Chemistry (2005)
• American Society for Clinical Pathology (2015)