The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.
My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.
It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.
- Medical School
- UT Southwestern Medical School (1998)
- University of Alabama Medical Center, Birmingham (1999), Internal Medicine
- University of Alabama Medical Center, Birmingham (2001), Internal Medicine
- UT Southwestern Medical Center (2004), Gastroenterology
- Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.
- Browning JD, Horton JD J. Lipid Res. 2010 Nov 51 11 3359-63
- Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.
- Browning JD, Cohen JC, Hobbs HH Hepatology 2010 Oct 52 4 1189-92
- Colonoscopy: an unusual complication.
- Alder AC, Scott DL, Browning JD Gastroenterology 2010 Feb 138 2 434, 794
- New imaging techniques for non-alcoholic steatohepatitis.
- Browning JD Clin Liver Dis 2009 Nov 13 4 607-19
- Ethnic differences in hepatic steatosis: an insulin resistance paradox?
- Guerrero R, Vega GL, Grundy SM, Browning JD Hepatology 2009 Mar 49 3 791-801
- Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis.
- Burgess SC, Chandramouli V, Browning JD, Schumann WC, Previs SF J. Appl. Physiol. 2008 Jun 104 6 1852-3; author reply 1854-5
- A case of diarrhea, ataxia, and capsule endoscope retention.
- Guerrero R, Lara LF, Browning JD Dig. Dis. Sci. 2007 Nov 52 11 3174-7
- Statins and hepatic steatosis: perspectives from the Dallas Heart Study.
- Browning JD Hepatology 2006 Aug 44 2 466-71
- Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.
- Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL Am. J. Physiol. Endocrinol. Metab. 2005 Feb 288 2 E462-8
- Combination therapy for the treatment of hepatitis C in the veteran population: higher than expected rates of therapy discontinuation.
- Getachew Y, Browning JD, Prebis M, Rogers T, Brown GR Aliment. Pharmacol. Ther. 2004 Sep 20 6 629-36
Gallstone Disease. In Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Browning JD, Sreenarasimhaiah J (2006). Philadelphia, Saunders
Honors & Awards
- Margo A. Denke, M.D. Professorship in Clinical Nutrition Research
University of Texas Southwestern Medical School, Dallas, TX (2017)
- Disease Oriented Clinical Scholar (DOCS)
University of Texas Southwestern Medical School, Dallas, TX (2006)
American Board of Internal Medicine, Gastroenterology (2005)
- Research Excellence in GI and Liver (REGAL) Award
University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
- NIH Training Fellowship
- Postdoctoral Fellowship
American Liver Foundation (2003)
American Board of Internal Medicine (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (1998)
- Medical Director (2010)