The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.
My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.
It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.
- Medical School
- UT Southwestern Medical School (1998)
- University of Alabama Medical Center, Birmingham (1999), Internal Medicine
- University of Alabama Medical Center, Birmingham (2001), Internal Medicine
- UT Southwestern Medical Center (2004), Gastroenterology
- Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
- Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC Am. J. Physiol. Endocrinol. Metab. 2010 Jun 298 6 E1226-35
- Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
- Browning JD, Weis B, Davis J, Satapati S, Merritt M, Malloy CR, Burgess SC Hepatology 2008 Nov 48 5 1487-96
- Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
- Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC Diabetes 2008 Aug 57 8 2012-21
- Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
- Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA Cell Metab. 2007 Apr 5 4 313-20
- A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content.
- Browning JD, Davis J, Saboorian MH, Burgess SC Hepatology 2006 Aug 44 2 487-8
- Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.
- Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH Hepatology 2004 Dec 40 6 1387-95
- Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine.
- Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC Am. J. Physiol. Gastrointest. Liver Physiol. 2018 Apr
- Racial and Ethnic Disparities in Non-alcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis.
- Rich NE, Oji S, Mufti AR, Browning JD, Parikh ND, Odewole M, Mayo H, Singal AG Clin. Gastroenterol. Hepatol. 2017 Sep
- Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
- Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2016 Apr 126 4 1605
- Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
- Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR Nat. Med. 2015 Feb 21 2 108-9
Gallstone Disease. In Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Browning JD, Sreenarasimhaiah J (2006). Philadelphia, Saunders
Honors & Awards
- Margo A. Denke, M.D. Professorship in Clinical Nutrition Research
University of Texas Southwestern Medical School, Dallas, TX (2017)
- Disease Oriented Clinical Scholar (DOCS)
University of Texas Southwestern Medical School, Dallas, TX (2006)
American Board of Internal Medicine, Gastroenterology (2005)
- Research Excellence in GI and Liver (REGAL) Award
University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
- NIH Training Fellowship
- Postdoctoral Fellowship
American Liver Foundation (2003)
American Board of Internal Medicine (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (1998)
- Medical Director (2010)