The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.
My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.
It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.
- Medical School
- UT Southwestern Medical School (1998)
- University of Alabama Medical Center, Birmingham (1999), Internal Medicine
- University of Alabama Medical Center, Birmingham (2001), Internal Medicine
- UT Southwestern Medical Center (2004), Gastroenterology
- Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.
- Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5
- Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
- Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr
- Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping.
- Mchenry S, Sharma Y, Tirath A, Tsai R, Mintz A, Fraum TJ, Salter A, Browning JD, Flores AG, Davidson NO, Fowler KJ, Ciorba MA, Deepa P, Clin. Gastroenterol. Hepatol. 2019 Mar
- Fatty Liver Disrupts Glycerol Metabolism in Gluconeogenic and Lipogenic Pathways in Humans.
- Jin ES, Browning JD, Murphy RE, Malloy CR J. Lipid Res. 2018 Jul
- Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
- Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2015 Dec 125 12 4447-4462
- Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic Fatty liver disease.
- Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ Gastroenterology 2014 Mar 146 3 726-35
- Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
- Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC J. Lipid Res. 2012 Jun 53 6 1080-92
- Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.
- Sunny NE, Parks EJ, Browning JD, Burgess SC Cell Metab. 2011 Dec 14 6 804-10
- Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
- Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC Am. J. Physiol. Endocrinol. Metab. 2010 Jun 298 6 E1226-35
- Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
- Browning JD, Weis B, Davis J, Satapati S, Merritt M, Malloy CR, Burgess SC Hepatology 2008 Nov 48 5 1487-96
Gallstone Disease. In Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Browning JD, Sreenarasimhaiah J (2006). Philadelphia, Saunders
Honors & Awards
- Margo A. Denke, M.D. Professorship in Clinical Nutrition Research
University of Texas Southwestern Medical School, Dallas, TX (2017)
- Holder, Lancaster Family Fund in Gastroenterology
University of Texas Southwestern Medical School, Dallas, TX (2010)
- Disease Oriented Clinical Scholar (DOCS)
University of Texas Southwestern Medical School, Dallas, TX (2006)
American Board of Internal Medicine, Gastroenterology (2005)
- Research Excellence in GI and Liver (REGAL) Award
University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
- NIH Training Fellowship
- Postdoctoral Fellowship
American Liver Foundation (2003)
American Board of Internal Medicine (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (1998)
- Medical Director (2010)