Dr. Tara Tassin is a faculty member in the Division of Cardiology within the Department of Internal Medicine. She received her undergraduate degree in Biochemistry from the University of Dallas and her doctorate degree in Molecular Biophysics from the University of Texas Southwestern Medical Center at Dallas, having developed a novel NMR method for measuring protein interactions and studying the peripheral neuropathy, Charcot-Marie-Tooth disease. She completed her postdoctoral fellowship in psychiatry, studying the regulation of ionotropic and G-protein coupled receptor neurotransmission with Dr. James A. Bibb at the University of Texas Southwestern Medical Center at Dallas. Dr. Tassin joined the laboratory of Dr. Pradeep Mammen in November 2017. Her research examines molecular mechanisms underlying Duchenne Muscular Dystrophy-associated cardiomyopathy and heart failure.
- Graduate School
- University of Dallas (2010), Biophysics
- University of Dallas (2016), Biochemistry
- Heart Failure
- Molecular Signaling
- Neuromuscular Cardiomyopathy
- Oxidative Stress
- Regenerative Medicine
- The role of ventral striatal cAMP signaling in stress-induced behaviors.
- Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA, Nat. Neurosci. 2015 Aug 18 8 1094-100
- Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain.
- Tassin TC, Benavides DR, Plattner F, Nishi A, Bibb JA, J. Biol. Chem. 2015 Jun 290 26 16319-29
- Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.
- Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP, Biochim. Biophys. Acta 2015 Jun 1850 6 1310-8
- The proline/arginine-rich domain is a major determinant of dynamin self-activation.
- Barylko B, Wang L, Binns DD, Ross JA, Tassin TC, Collins KA, Jameson DM, Albanesi JP, Biochemistry 2010 Dec 49 50 10592-4
- The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.
- Deford-Watts LM, Tassin TC, Becker AM, Medeiros JJ, Albanesi JP, Love PE, Wülfing C, van Oers NS, J. Immunol. 2009 Jul 183 2 1055-64
- Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy.
- Araç D, Murphy T, Rizo J Biochemistry 2003 Mar 42 10 2774-80
Honors & Awards
- Best of Basic Cardiovascular Research
American Heart Association (2018)
- Second Place, Clinical Research
UT Southwestern - Texas Health Resources Cardiovascular Symposium Poster Competition (2018)
- American Heart Association (2018)