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Denise Ramirez, Ph.D., studied brain cholesterol metabolism and its effects on learning and memory in the laboratory of Dr. David Russell, Ph.D., for her Ph.D. thesis. She then went on to study the role of novel SNARE proteins in spontaneous neurotransmission during postdoctoral work in the laboratory of Dr. Ege Kavalali, Ph.D. Dr. Ramirez was the founding Core Manager since 2014 and now serves as the Director of the UTSW Whole Brain Microscopy Facility (WBMF) in the Department of Neurology. She leverages her 20 years of hands-on optical imaging experience to facilitate the use of unique high-throughput volumetric imaging technologies and identify novel anatomical information to promote both basic and translational neuroscience. For more information on the WBMF, our instrumentation and services, please see the links to the right. I welcome you to contact me with any questions you may have about our facility.


Office location – NL10.125B


Saint Mary's University (2003), Biology
Graduate School
UT Southwestern Medical Center (2009), Biology

Research Interest

  • 3D reconstruction
  • connectomics
  • digital pathology
  • histology
  • image analysis
  • neuroscience
  • serial two-photon tomography
  • stroke
  • volumetric imaging


Featured Publications LegendFeatured Publications

Jackson LA, Hare AM, Carrick KS, Ramirez DMO, Hamner JJ, Corton MM, Am. J. Obstet. Gynecol. 2020 Sep
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.
Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET, J. Neurosci. 2020 Jun


Featured Books Legend Featured Books

Professional Associations/Affiliations

  • Association of Biomolecular Resource Facilities (ABRF) (2019)
  • Society for Neuroscience (2009)