
Jay Gibson, Ph.D.
Associate Professor
Department Neuroscience
Graduate Programs Neuroscience
Biography
As an undergraduate, Dr. Gibson studied biophysics at the University of California at Berkeley. Under the guidance of Dr. John Maunsell, he completed his PhD in 1995 at the University of Rochester, which focused on neocortical activity related to visual processing. Next, he worked under Dr. Barry Connors studying the electrophysiological properties of inhibitory interneurons in somatosensory cortex.
Dr. Gibson joined the Center for Basic Neuroscience at UT Southwestern in 2001. Currently, the lab uses electrophysiological techniques to study the plasticity of cortical inhibitory circuitry and alterations in circuitry in the Fragile X Syndrome mouse model. A post doc position is currently available, and interested candidates are welcome to contact through email.
Education
- Graduate School
- University of Rochester (1995)
Research Interest
- Electrophysiology
- Neuronal Circuits in Neocortex
- Neuroscience
Publications
Featured Publications
- Postsynaptic FMRP Promotes the Pruning of Cell-to-Cell Connections among Pyramidal Neurons in the L5A Neocortical Network.
- Patel AB, Loerwald KW, Huber KM, Gibson JR J. Neurosci. 2014 Feb 34 9 3413-8
- A Target Cell-Specific Role for Presynaptic Fmr1 in Regulating Glutamate Release onto Neocortical Fast-Spiking Inhibitory Neurons.
- Patel AB, Hays SA, Bureau I, Huber KM, Gibson JR J. Neurosci. 2013 Feb 33 6 2593-604
- Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
- Hays SA, Huber KM, Gibson JR J. Neurosci. 2011 Oct 31 40 14223-34
- A role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neurons
- Gibson, J. R., Bartley, A. F., and Huber, K. M. J. Neurophysiol. 2006 96(1) 420-432
- Two electrically coupled inhibitory networks
- Gibson, J. R., Beierlein, M., and Connors, B. W. Nature 1999 402(4) 75-79
- A Role for Dendritic mGluR5-Mediated Local Translation of Arc/Arg3.1 in MEF2-Dependent Synapse Elimination.
- Wilkerson JR, Tsai NP, Maksimova MA, Wu H, Cabalo NP, Loerwald KW, Dictenberg JB, Gibson JR, Huber KM Cell Rep 2014 May
- Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.
- Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR, Huber KM Nat. Neurosci. 2012 Mar 15 3 431-40, S1
- Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2. Neuron
- Chubykin, A.A., Atasoy, D., Etherton, M.R., Brose, N., Kavalali, E.T., Gibson, J.R., Sudhof, T.C. Neuron 2007 54(6) 919-931
- A role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neurons
- Gibson, J. R., Bartley, A. F., and Huber, K. M. J. Neurophysiol. 2006 96(1) 420-432
- Functional Properties of Electrical Synapses Between Inhibitory Neurons of Neocortical Layer 4
- Gibson, J. R., Beierlein, M., and Connors, B. W. J. Neurophysiol. 2005 93(1) 467-480
Honors & Awards
- FRAXA Fellowship
Research for Fragile X Syndrome (2006) - Klingenstein Fellowship
Award in the Neurosciences (2002)