Dr. Self received his bachelor’s in Zoology from Iowa State University in 1985, and worked as a biochemist at Endocrine Sciences in Los Angeles, CA until 1987. Dr. Self entered graduate school in 1987 in the Department of Pharmacology at UC Irvine, and received a Ph.D. there in 1992. Dr. Self was a postdoctoral fellow from 1992-1995 in the Division of Molecular Psychiatry at Yale University. Dr. Self was appointed to an Assistant Professorship in the Psychiatry Department at Yale University in 1996.
In late 2000, Dr. Self joined the UT Southwestern faculty as an Associate Professor of Psychiatry in the Seay Center for Basic and Applied Research in Psychiatric Illness. Dr. Self has pioneered work on the role of neuroadaptations in addictive behavior, and has identified important neurobiological mechanisms underlying drug craving and relapse to drug seeking. In 1996, he was awarded a Presidential Early Career Award by the White House, and in 2006, the prestigious Daniel H. Efron Award by the American College of Neuropsychopharmacology, for contributions relating to this work. Dr. Self was appointed Director of the Psychiatry Neuroscience Division in 2013. His laboratory continues to implement modern molecular technology in the study of addictive behavior.
- Iowa State Univ Science & Tech (1985), Zoology
- Graduate School
- University of California-Irvin (1992), Pharmacology
- Behavioral Neuroscience
- Neurobiology of Addiction
- Systems Neuroscience
- Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety.
- Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW Neuropsychopharmacology 2018 Dec
- Viral Vector Targeting of Specific Brain Circuits in Neuropsychiatric Disease Models.
- Self DW Pharmacol. Biochem. Behav. 2018 Nov 174 1
- HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
- Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW Neuron 2017 Sep 96 1 130-144.e6
- Incubation of cue-induced reinstatement of cocaine, but not sucrose, seeking in C57BL/6J mice.
- Nugent AL, Anderson EM, Larson EB, Self DW Pharmacol. Biochem. Behav. 2017 Jun 159 12-17
- It's only a matter of time: longevity of cocaine-induced changes in dendritic spine density in the nucleus accumbens.
- Anderson EM, Self DW Curr Opin Behav Sci 2017 Feb 13 117-123
- Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration.
- Edwards S, Bachtell RK, Guzman D, Whisler KN, Self DW Addict Biol 2011 Jul 16 3 450-7
- Striatal signal transduction and drug addiction.
- Philibin SD, Hernandez A, Self DW, Bibb JA Front Neuroanat 2011 5 60
- Striatal regulation of ?FosB, FosB, and cFos during cocaine self-administration and withdrawal.
- Larson EB, Akkentli F, Edwards S, Graham DL, Simmons DL, Alibhai IN, Nestler EJ, Self DW J. Neurochem. 2010 Oct 115 1 112-22
- Stress-related receptor targets for cocaine addiction.
- Self DW Biol. Psychiatry 2010 Aug 68 3 217-8
- Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats.
- Bachtell RK, Self DW Psychopharmacology (Berl.) 2009 Oct 206 3 469-78
Integrating Behavioral and Molecular Approaches in Mouse: Self-Administration Studies.. In In: Kuhn CM, Koob GF, editors. Advances in the Neuroscience of Addiction. 2nd edition. Chapter 5.
Graham DL, Self DW. (2010). Boca Raton (FL):, CRC Press
Dopamine receptor subtypes in reward and relapse.. In The Dopamine Receptors: Second Edition, Neve, K. ed.
Self, D.W. (2010). Humana Press
Behavioral Neuroscience of Drug Addiction. Current Topics in Behavioral Neuroscience Vol. 3
Self, D.W. and Staley, J.K. (Ed.) (2010). Berlin, Springer-Verlag
Honors & Awards
- American College of Neuropsychopharmacology
Elected to Fellow (2011)
- Daniel H. Efron Research Award
American College of Neuropsychopharmacology (2006)
- Lydia Bryant Test Professorship
Dept. of Psychiatry. UT Southwestern Medical Center (2001)
- Presidential Early Career Award for Scientists and Engineers (PECASE)
Awarded by the White House for "Innovative integration of molecular biology with behavioral, pharmacological and biochemical techniques in the study of drug addiction" (1996)
- American College of Neuropsychopharmacology
- College on Problems of Drug Dependence
- European Behavioural Pharmacology Society
- Society for Neuroscience
- Society of Biological Psychiatry