Shawn C. Burgess obtained his PhD in Chemistry in 2000 from the University of Texas at Dallas for research on using carbon-13 tracers and nuclear magnetic resonance (NMR) to examine metabolic flux. From 2000-2003 he was a postdoctoral research scientist in the Department of Radiology at UT Southwestern where he studied substrate metabolism in β-cell and liver using tracer approaches.

In the Center for Human Nutrition, the Burgess Lab uses stable isotope tracers, NMR and mass spectrometry to study how metabolic flux is regulated by molecular physiology and altered by disease or pharmacology.  His lab focuses on pathways of oxidative and biosynthetic metabolism in the context of obesity, insulin resistance and diabetes.  They seek to understand how metabolic mechanisms contribute to pathologies of disease such as steatosis, oxidative stress and inflammation.    


Graduate School
University of Texas at Dallas (1997), Chemistry
Graduate School
University of Texas at Dallas (2000), Chemistry

Research Interest

  • Biological NMR and MS
  • In Vivo and Ex Vivo isotope tracer techniques
  • Intermediary metabolism of obesity and diabetes
  • Metabolic mechanisms of disease
  • Regulation of carbohydrate and lipid metabolism in liver


Featured Publications LegendFeatured Publications

Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.
Merritt M, Bretthorst GL, Burgess SC, Sherry AD, Malloy CR Magn Reson Med 2003 Oct 50 4 659-63
Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis.
Jin ES, Uyeda K, Kawaguchi T, Burgess SC, Malloy CR, Sherry AD J. Biol. Chem. 2003 Aug 278 31 28427-33
Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry.
Burgess SC, Nuss M, Chandramouli V, Hardin DS, Rice M, Landau BR, Malloy CR, Sherry AD Anal. Biochem. 2003 Jul 318 2 321-4
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA Diabetes 2003 Jul 52 7 1649-54
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
Burgess SC, Weis B, Jones JG, Smith E, Merritt ME, Margolis D, Dean Sherry A, Malloy CR Anal. Biochem. 2003 Jan 312 2 228-34
Comparison of 2H2O Measured Gluconeogenesis Determined by Both NMR and MS
Shawn C Burgess, Merrill Nuss, Bernard R Landau, A Dean Sherry and Craig R Malloy Analytical Biochemistry 2003 318 321-324
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).
Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD Proc. Natl. Acad. Sci. U.S.A. 2002 Mar 99 5 2708-13
13C NMR Isotopomer Analysis Reveals a Connection Between Pyruvate Cycling and Glucose-Stimulated Insulin Secretion (GSIS)
Danhong Lu, Hindrik Mulder, Piyu Zhao, Shawn C Burgess, Mette V Jensen, Svetlana Kamzolova, Christopher B Newgard and A Dean Sherry PNAS 2002 99 2708-2713
NMR indirect detection of glutamate to measure citric acid cycle flux in the isolated perfused mouse heart.
Burgess SC, Babcock EE, Jeffrey FM, Sherry AD, Malloy CR FEBS Lett. 2001 Sep 505 1 163-7
13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.
Burgess SC, Carvalho RA, Merritt ME, Jones JG, Malloy CR, Sherry AD Anal. Biochem. 2001 Feb 289 2 187-95

Honors & Awards

  • Daryl K. Granner Lectureship
  • Robert A. Welch Foundation Research Grant Award
  • ADA Basic Science Award
  • American Diabetes Junior Faculty Award

Professional Associations/Affiliations

  • American Diabetes Association (2003)
  • American Chemical Society (1994)
  • International Society for Magnetic Resonance in Medicine